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  3. MZP-55

MZP-55 

Cat. No.: HY-112377 Purity: 99.75%
Handling Instructions

MZP-55 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 8 nM for Brd4BD2.

For research use only. We do not sell to patients.

MZP-55 Chemical Structure

MZP-55 Chemical Structure

CAS No. : 2010159-48-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 1010 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1600 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

MZP-55 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 8 nM for Brd4BD2.

IC50 & Target

Kd: 8 nM (Brd4BD2)[1]

In Vitro

MZP-55 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 8 nM for Brd4BD2. MZP-55 binds to VHL-EloC-EloB protein (VCB) with a Kd of 105 ± 24 nM. MZP-55 shows an inhibitory activity against MV4;11 and HL60 cells, with pEC50s of 7.31 ± 0.03 and 6.57 ± 0.02, respectively[1].

Molecular Weight

1080.72

Formula

C₅₇H₇₀ClN₇O₁₀S

CAS No.

2010159-48-3

SMILES

CC(N=CS1)=C1C2=CC=C(CNC([[email protected]@H]3C[[email protected]@H](O)CN3C([[email protected]](C(C)(C)C)NC(COCCOCCOCCOCCNC(C(C=C4)=CC=C4C5=CC6=C(C=C5)N(C(C)=O)[[email protected]@H](C)C[[email protected]]6NC7=CC=C(Cl)C=C7)=O)=O)=O)=O)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (46.27 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9253 mL 4.6265 mL 9.2531 mL
5 mM 0.1851 mL 0.9253 mL 1.8506 mL
10 mM 0.0925 mL 0.4627 mL 0.9253 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.31 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[1]

MV4;11 or HL60 cells are incubated with MZP-55 at the desired concentration for 48 h on a clear-bottom 384-well plate. Cells are kept in RPMI medium supplemented with 10% FBS, l-glutamine, penicillin, and streptomycin. Initial cell density is 3 × 105 per mL. Cells are treated with various concentrations of MZP-55 or 0.05% DMSO. After treatment, cell viability is measured with cell viability assay kit. Signal is recorded. Data are analyzed with Graphpad Prism software to obtain EC50 values of each MZP-55[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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MZP-55
Cat. No.:
HY-112377
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