2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Phosphatase

Phosphatase

Phosphatase

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Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-156659
    NC1
    		Inhibitor 98.73%
    NC1 is a selective non-competitive and allosteric lymphoid-specific tyrosine phosphatase (LYP) inhibitor, with a Ki value 4.3 μM. NC1 allosterically regulates LYP/PTPN22 activity by restricting WPD loop movement. NC1 inhibits LYP activity in lymphoid T cells and enhances T-cell receptor signaling. NC1 can be used for the research of autoimmune diseases.
    NC1
  • HY-N4288
    4-Methylesculetin
    		Inhibitor 99.27%
    4-Methylesculetin is an orally active coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity. 4-Methylesculetin protects bone resorption by reducing the elevated levels of bone-joint exoglycosidases, cathepsin-D and tartrate resistant acid phosphatases. 4-Methylesculetin ameliorats the upregulated non-enzymatic inflammatory markers like TNF-α, IL-1β, IL-6, COX-2 and PGE2, which is promising for research of inflammatory diseases.
    4-Methylesculetin
  • HY-D1208
    Alkaline phosphatase substrate
    Alkaline phosphatase substrate is a chemiluminescent substrate for alkaline phosphatase. Alkaline phosphatase substrate can be used for enzyme-linked immunoassays.
    Alkaline phosphatase substrate
  • HY-112832
    Lumigen APS-5
    		Inhibitor 98.0%
    Lumigen APS-5 is a substrate of alkaline phosphatase (ALP). Lumigen APS-5 can be used to assess the activity of alkaline phosphatase (ALP).
    Lumigen APS-5
  • HY-N2511
    Trimyristin
    		Inhibitor 99.72%
    Trimyristin is an orally active compound. Trimyristin can be isolated from the seeds of nutmeg (Myristica fragrans). Trimyristin inhibits the activities of acetylcholinesterase (AChE), ACP and ALP, with IC50 values of 0.11, 0.16 and 0.18 mM, respectively. Trimyristin exerts competitive-noncompetitive inhibition on acetylcholinesterase, uncompetitive inhibition on ACP, and competitive/noncompetitive inhibition on ALP. Trimyristin restores the downregulated acetylcholinesterase concentration in the cerebral cortex of rats exposed to sodium arsenite. Trimyristin can be used in studies related to fascioliasis and neurotoxicity.
    Trimyristin
  • HY-120354
    YU142670
    		Inhibitor 99.50%
    YU142670 is an inhibitor of OCRL/INPP5B with IC50 values of 0.71 μM and 1.78 μM respectively.
    YU142670
  • HY-151591
    SPAA-52
    		Inhibitor
    SPAA-52 is an orally active, competitive and reversible low-molecular-weight protein tyrosine phosphatase (LMW-PTP) inhibitor (IC50=4 nM, Ki=1.2 nM). SPAA-52 can be used in diabete research.
    SPAA-52
  • HY-131132A
    JAB-3068 hydrochloride
    		Inhibitor 98.88%
    JAB-3068 (SHP2-IN-6) hydrochloride is a potent SHP2 inhibitor with an IC50 of 25.8 nM. JAB-3068 hydrochloride is extracted from patent WO2017211303A1, compound 7.
    JAB-3068 hydrochloride
  • HY-130913
    5-FAM-Alkyne
    5-FAM-Alkyne is a high selective and sensitive fluorescent biosensor for alkaline phosphatase (ALP). 5-FAM-Alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    5-FAM-Alkyne
  • HY-115759
    N-Octylmaleimide
    		99.98%
    N-Octylmaleimide is an alkylmaleimide, which can inhibit rat liver glucose 6-phosphatase.
    N-Octylmaleimide
  • HY-N0646
    Silydianin
    		Inhibitor 99.71%
    Silydianin is a flavonolignan. Silydianin can be obtained from Silybum marianum. Silydianin inhibits PTP1B with an IC50 of 17.38 μM. Silydianin inhibits both monophenolase and diphenolase of tyrosinase significantly, with IC50s of 2.6 μM and 16.5 μM, respectively. Silydianin induces Apoptosis and reduces cytokines (IL-4 and IL-5). Silymarin has antioxidant, cytoprotective and immunomodulatory effects. Silydianin has antitumor activity against prostate cancer. Silymarin can be used in allergic asthma research.
    Silydianin
  • HY-148508
    PhosTAC3
    		Inhibitor 99.97%
    PhosTAC3 is a phosphorylation targeting chimera (PhosTAC) molecule composed of a linker with three PEG groups. PhosTAC3 induces dephosphorylation of PDCD4 and FOXO3a.
    PhosTAC3
  • HY-19779
    JTT 551
    		Inhibitor 99.65%
    JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively; JTT 551 can be used in the research of type 2 diabetes mellitus.
    JTT 551
  • HY-163782
    SMIP-031
    		Inhibitor 98.60%
    SMIP-031 is a potent and orally active PPM1A inhibitor with an IC50 value of 180 nM. SMIP-031 induces autophagy. SMIP-031 inhibits Mycobacterium tuberculosis infect in mice.
    SMIP-031
  • HY-161321
    PTP1B-IN-24
    		Inhibitor 98.46%
    PTP1B-IN-24 (Compound 9) is a reversible PTP1B inhibitor with an IC50 value of 1.4 μM, and PTP1B-IN-24 can enhance the thermal stability of PTP1B. PTP1B-IN-24 can restore PA- (HY-N0830) induced insulin resistance by increasing the phosphorylation levels of IRS1 and AKT.
    PTP1B-IN-24
  • HY-115925
    SHP2-IN-9
    		Inhibitor 98.80%
    SHP2-IN-9 is a specific SHP2 inhibitor (IC50 =1.174 μM) with enhanced blood–brain barrier penetration. SHP2-IN-9 shows 85-fold more selective for SHP2 than SHP1. SHP2-IN-9 inhibits SHP2-mediated cell signal transduction and cancer cell proliferation, and inhibits the growth of cervix cancer tumors and glioblastoma growth in vivo.
    SHP2-IN-9
  • HY-148509
    PhosTAC5
    		98.02%
    PhosTAC5 is a phosphorylation targeting chimera (PhosTAC) molecule composed of a linker with fivePEG groups. PhosTAC5 induces dephosphorylation of PDCD4 and FOXO3a.
    PhosTAC5
  • HY-162428
    PTPN2/1-IN-3
    		Inhibitor 99.89%
    PTPN2/1-IN-3 (compound 4) is a modified, orally active PTPN2/N1 inhibitor based on ABBV-CLS-484 (HY-145923). PTPN2/1-IN-3 has anti-tumor effects, inhibiting PTPN2 with an IC50 of 9.3 nM and having an oral bioavailability of 93% in mice.
    PTPN2/1-IN-3
  • HY-N9326
    Uralenol
    		Inhibitor 99.12%
    Uralenol is a natural PTP1B inhibitor (IC50=21. 5 μM) from Broussonetia papyrifera. PTP1B have been shown to play a major role in the dephosphorylation of the insulin receptor in many cellular and biochemical studies.
    Uralenol
  • HY-129409
    7,8-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
    		Inhibitor 99.49%
    7,8-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one (7,8,4'-Trihydroxyisoflavone) is a product that can be isolated from .
    7,8-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity