Art. -Nr.: HY-108599

DCP-LA

Name: DCP-LA
Brand: MedChemExpress
SKU: HY-108599
Price: 99.00 USD
Availability: InStock
Rating: 5 (9 reviews)

(Synonyms: FR236924)

9 Cited Publications

Kundenbewertung

Based on 9 publication(s) in Google Scholar

DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca(²⁺)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis.

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Reinheit : 98.0%
CAS. Nr.: 28399-31-7
Formel: C₂₀H₃₆O₂
Molecular Weight:308.50

Speicherung:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

DCP-LA Chemical Structure

CAS. Nr.: 28399-31-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (9)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]^[3]

PKCε

CaMK II

Alle PKC Isoform-spezifische Produkte anzeigen :

Alle CaMK Isoform-spezifische Produkte anzeigen :

In Vitro

DCP-LA (100 nM; 15 min) activates cytosolic PKCε by binding to the phosphatidylserine binding/associating sites Arg50 and Ile89, without translocation towards the cell surface in PL-12 cells^[1].
DCP-LA (10, 100, 100 nM; 10 min; 35 °C) activates CaMKII and inhibits PP-1 in rat hippocampal neurons^[2].
DCP-LA (100 nM; 20 min) increases expression of the receptors on the plasma membrane, responsible for potentiate AMPA receptor responses in rat hippocampal slices^[2].
DCP-LA (100 nM; 10 min) results facilitation of hippocampal synaptic transmission^[2].
DCP-LA (100 nM; 24 h) prevents the Sodium nitroprusside (SNP, HY-10219) effect and rescues neurons from SNP-induced degradation^[3].
DCP-LA (100 nM; 12 h) abolishes the caspase-3/9 activation induced by (SNP, HY-10219) (1 mM)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:

Rat cerebral cortical neurons
Concentration:

100 nM
Incubation Time:

24 hours; accompanied with 1 mM Sodium nitroprusside (SNP)
Result:

Prevented SNP-induced neuronal cell death.

In Vivo

DCP-LA (1 mg/kg; p.o.; once daily; 7 d) exhibits a protective effect against ischemic brain damage, decreasing cerebral cortical defect due to middle cerebral artery (MCA) occlusion in mouse model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Middle cerebral artery (MCA) occlusion in mouse model (male CB-17 mice, 5-8 weeks old)^[3]
Dosage:

1 mg/kg
Administration:

Oral gavage; once daily for 7 days; sacrificed mice on days 28
Result:

Significantly diminished degraded area due to cerebral infarction, with the rescued area reaching 82%.

Chemical Information

CAS. Nr. 28399-31-7
Appearance Liquid (Density: 0.968 g/cm³)
Molecular Weight 308.50
Formel C₂₀H₃₆O₂
Color Colorless to light yellow
SMILES

O=C(O)CCCCCCCC1C(CC2C(CCCCC)C2)C1
Synonyms

FR236924
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (9)

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Journal Impact Factor

Cell Metab

Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis. [Abstract]

2023 Jan 3;35(1):101-117.e11. PMID: 36525963
Cell Death Dis

Hepatic deficiency of selenoprotein S exacerbates hepatic steatosis and insulin resistance. [Abstract]

2022 Mar 28;13(3):275. PMID: 35347118
J Genet Genomics

Compound heterozygous mutations of NTNG2 cause intellectual disability via inhibition of the CaMKII signaling. [Abstract]

2024 Nov;51(11):1204-1214. PMID: 39151821
J Ethnopharmacol

Buyang Huanwu Decoction restores the balance of mitochondrial dynamics after cerebral ischemia-reperfusion through calcium overload reduction by the PKCε-Nampt-Sirt5 axis. [Abstract]

2025 Feb 10;338(Pt 3):119003. PMID: 39528118
Cell Mol Life Sci

Obesity-induced oleic acid metabolic dysregulation may exacerbate osteoarthritis through the degradation of SOX9. [Abstract]

2026 May 22. PMID: 42171703

DCP-LA purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2026 May 22. [Abstract]

Immunoblot detection of p-CaMK2, CaMK2, ACAN and COL2A1 protein in mouse primary chondrocytes treated with DCP-LA (0.2 µM) for 7 d.

DCP-LA purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2026 May 22. [Abstract]

Alcian blue and Toluidine blue staining to examine the proteoglycan content after DCP-LA (0.2 µM) treatment for 14 d.

DCP-LA purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2026 May 22. [Abstract]

Quantification of mRNA levels for ACAN, COL2A1, MMP13 and ADAMTS5 in mouse primary chondrocytes treated with DCP-LA (0.2 µM) for 3 d.
Biochem Pharmacol

Triptolide induces the secretion of insulin, through which it alleviates the tauopathies of Alzheimer's disease via inhibiting the phosphorylation of tau. [Abstract]

2025 Aug 8;242(Pt 3):117223. PMID: 40784568
Transl Res

sFRP5 ameliorates atherosclerosis by suppressing the JNK/TLR9 pathway in macrophages. [Abstract]

2025 Jul:281:1-13. PMID: 40409587
Int Immunopharmacol

Multi-omics integration identifies CACNG3 as a synaptic calcium channel regulator in Alzheimer's disease: Mechanistic insights and therapeutic implications. [Abstract]

2026 Feb 15:171:116139. PMID: 41483619
J Ovarian Res

Long non-coding ribonucleic acid SNHG18 induced human granulosa cell apoptosis via disruption of glycolysis in ovarian aging. [Abstract]

2024 Sep 13;17(1):185. PMID: 39272131

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (324.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.2415 mL

16.2075 mL

32.4149 mL

5 mM

0.6483 mL

3.2415 mL

6.4830 mL

10 mM

0.3241 mL

1.6207 mL

3.2415 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (8.10 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (8.10 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (8.10 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kanno T, et al. DCP-LA Activates Cytosolic PKCε by Interacting with the Phosphatidylserine Binding/Associating Sites Arg50 and Ile89 in the C2-Like Domain. Cell Physiol Biochem. 2015;37(1):193-200. [Content Brief]

[2]. Kanno T, et al. DCP-LA stimulates AMPA receptor exocytosis through CaMKII activation due to PP-1 inhibition. J Cell Physiol. 2009 Oct;221(1):183-8. [Content Brief]

[3]. Yaguchi T, et al. Linoleic acid derivative DCP-LA protects neurons from oxidative stress-induced apoptosis by inhibiting caspase-3/-9 activation. Neurochem Res. 2010 May;35(5):712-7. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.2415 mL	16.2075 mL	32.4149 mL	81.0373 mL
	5 mM	0.6483 mL	3.2415 mL	6.4830 mL	16.2075 mL
	10 mM	0.3241 mL	1.6207 mL	3.2415 mL	8.1037 mL
	15 mM	0.2161 mL	1.0805 mL	2.1610 mL	5.4025 mL
	20 mM	0.1621 mL	0.8104 mL	1.6207 mL	4.0519 mL
	25 mM	0.1297 mL	0.6483 mL	1.2966 mL	3.2415 mL
	30 mM	0.1080 mL	0.5402 mL	1.0805 mL	2.7012 mL
	40 mM	0.0810 mL	0.4052 mL	0.8104 mL	2.0259 mL
	50 mM	0.0648 mL	0.3241 mL	0.6483 mL	1.6207 mL
	60 mM	0.0540 mL	0.2701 mL	0.5402 mL	1.3506 mL
	80 mM	0.0405 mL	0.2026 mL	0.4052 mL	1.0130 mL
	100 mM	0.0324 mL	0.1621 mL	0.3241 mL	0.8104 mL

Bioz

Keywords

DCP-LA

9 Cited Publications

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DCP-LA

Publications Citing Use of MedChemExpress (MCE) DCP-LA

Alle PKC Isoform-spezifische Produkte anzeigen

Alle CaMK Isoform-spezifische Produkte anzeigen