CDK2-IN-9
CDK2-IN-9 is a potent CDK2 inhibitor with an IC50 of 0.63 µM. CDK2-IN-9 shows antiproliferative activity. CDK2-IN-9 induces apoptosis and cell cycle arrest at S and G2/M phase. CDK2-IN-9 has the potential for the research of melanoma.
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- CAS. Nr.: 2919216-33-2
- Formel: C21H16ClN3O4S
- Molecular Weight:441.89
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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CDK2 0.63 μM (IC50) |
CDK2-IN-9 (compound 5c) shows antiproliferative activity with IC50s of 3.03, 8.62, 62.52 µM for MDA-MB-435, SNB-75, WI-38 cells, respectively[1].
CDK2-IN-9 (24 h) induces apoptosis and cell cycle arrest in S and G2/M phase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-435, SNB-75 cells
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Concentration:3.03for MDA-MB-435 cells, 8.62 for SNB-75 cells
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Incubation Time:24 h
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Result:Induced apoptosis in MDA-MB-435 and SNB-75 cells with the percent of the total apoptosis of 28.65 and 44.22%, respectively.
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Cell Line:MDA-MB-435, SNB-75 cells
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Concentration:
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Incubation Time:24 h
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Result:Induced cell cycle arrest at S phase and G2/M.
Chemical Information
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CAS. Nr. 2919216-33-2
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Molecular Weight 441.89
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Formel C21H16ClN3O4S
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SMILES
O=S(C1=CC=C(Cl)C=C1)(NN2C(COC3=CC=CC=C3)=NC4=C(C=CC=C4)C2=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CDK2-IN-9 Related Classifications
HY-144811 Related Classifications
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