Art. -Nr.: HY-B0240

Disulfiram

(Synonyms: Tetraethylthiuram disulfide; TETD)

143 Cited Publications

Kundenbewertung

Based on 143 publication(s) in Google Scholar

Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram, a copper ion carrier, with Cu²⁺ increases intracellular ROS levels and induces cuproptosis.

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Reinheit: 99.77%
CAS. Nr.: 97-77-8
Formel: C₁₀H₂₀N₂S₄
Molecular Weight:296.54

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months

Disulfiram Chemical Structure

CAS. Nr.: 97-77-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (143)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Protokoll
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

IL-1β

Alle Aldehyde Dehydrogenase (ALDH) Isoform-spezifische Produkte anzeigen :

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	0.25 μM Compound: 29; DSF	Anticancer activity against mouse 4T1 cells assessed as cell growth inhibition by MTS assay Anticancer activity against mouse 4T1 cells assessed as cell growth inhibition by MTS assay	[PMID: 33650861]
CEM-SS	IC₅₀	>100 μM Compound: disulfiram	Antiviral activity against HIV-1ADA in CEM-SS cells using monocyte/macrophage cultures Antiviral activity against HIV-1ADA in CEM-SS cells using monocyte/macrophage cultures	[PMID: 9207937]
CEM-SS	IC₅₀	3.9 μM Compound: disulfiram	Antiviral activity against HIV-1 in CEM-SS cells using XXT assay Antiviral activity against HIV-1 in CEM-SS cells using XXT assay	[PMID: 9207937]
CHO	EC₅₀	3 μM Compound: 12	Agonist activity at human TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium levels Agonist activity at human TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium levels	[PMID: 20356305]
HepG2	IC₅₀	38 μM Compound: Disulfiram	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29571571]
MCF-10A	IC₅₀	10 μM Compound: 1, DSF	Antiproliferative activity against human MCF10A cells after 72 hrs by MTT assay Antiproliferative activity against human MCF10A cells after 72 hrs by MTT assay	[PMID: 20222671]
MCF7	IC₅₀	0.1 μM Compound: 1, DSF	Antiproliferative activity against human MCF7 cells expressing BCA2 and estrogen receptor after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells expressing BCA2 and estrogen receptor after 72 hrs by MTT assay	[PMID: 20222671]
MDA-MB-231	IC₅₀	>10 μM Compound: 1, DSF	Antiproliferative activity against BCA2 and ER deficient human MDA-MB-231 cells after 72 hrs by MTT assay Antiproliferative activity against BCA2 and ER deficient human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 20222671]
MDA-MB-231	IC₅₀	0.32 μM Compound: 1, DSF	Antiproliferative activity against human MDA-MB-231 cells expressing BCA2 and ERalpha after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells expressing BCA2 and ERalpha after 72 hrs by MTT assay	[PMID: 20222671]
T47D	IC₅₀	0.17 μM Compound: 1, DSF	Antiproliferative activity against human T47D cells expressing BCA2 and estrogen receptor after 72 hrs by MTT assay Antiproliferative activity against human T47D cells expressing BCA2 and estrogen receptor after 72 hrs by MTT assay	[PMID: 20222671]
THP-1	IC₅₀	0.41 μM Compound: 1	Induction of pyroptosis in human THP-1 cells assessed as cell death by measuring LDH release at 10 uM pretreated for 1 hrs followed by compound addition and measured after 2 hrs Induction of pyroptosis in human THP-1 cells assessed as cell death by measuring LDH release at 10 uM pretreated for 1 hrs followed by compound addition and measured after 2 hrs	[PMID: 38116411]
THP-1	IC₅₀	7 μM Compound: 1	Cytotoxicity against human THP-1 cells assessed as reduction in cell viability measured after 24 hrs by Celltiter-Glo assay Cytotoxicity against human THP-1 cells assessed as reduction in cell viability measured after 24 hrs by Celltiter-Glo assay	[PMID: 38116411]

In Vitro

Disulfiram-copper complex potently inhibits the proteasomal activity in cultured breast cancer MDA-MB-231 and MCF10DCIS.com cells, but not normal, immortalized MCF-10A cells, before induction of apoptotic cancer cell death^[1]. Disulfiram (DS), a clinically used anti-alcoholism drug, strongly inhibits constitutive and 5-FU-induced NF-kappaB activity in a dose-dependent manner. Disulfiram inhibits both NF-kappaB nuclear translocation and DNA binding activity but has no effect on 5-FU-induced IkappaBalpha degradation. Disulfiram significantly enhances the apoptotic effect of 5-FU on DLD-1 and RKO(WT) cell lines and synergistically potentiated the cytotoxicity of 5-FU to both cell lines. Disulfiram also effectively abolishes 5-FU chemoresistance in a 5-FU resistant cell line H630(5-FU) in vitro^[2]. Oseltamivir decreases the number of viable cells, and the addition of CuCl₂ significantly enhances the DSF-induced cell death to less than 10% of control^[3]. Disulfiram given to melanoma cells in combination with Cu²⁺ or Zn²⁺ decreases expression of cyclin A and reduces proliferation in vitro at lower concentrations than disulfiram alone^[4].
Disulfiram (0.1 nM-10 μM; 72 h) + Cu²⁺ combination enhances the cytotoxicity on ovarian cancer cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Disulfiram significantly inhibits the tumor growth (by 74%), associated with in vivo proteasome inhibition and apoptosis induction in mice bearing MDA-MB-231 tumor xenografts^[1].
Proteasome inhibition is measured by decreased levels of tumor tissue proteasome activity and accumulation of ubiquitinated proteins and natural proteasome substrates p27 and Bax^[1].
Apoptosis is shown by caspase activation and apoptotic nuclei formation^[1].
Disulfiram blocks the P-glycoprotein extrusion pump, inhibits the transcription factor nuclear factor-kappaB, sensitizes tumors to chemotherapy, reduces angiogenesis, and inhibits tumor growth in mice^[4].
Disulfiram inhibits growth and angiogenesis in melanomas transplanted in severe combined immunodeficient mice, and these effects are potentiated by Zn²⁺ supplementation^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 97-77-8
Appearance Solid
Molecular Weight 296.54
Formel C₁₀H₂₀N₂S₄
Color White to yellow
SMILES

S=C(SSC(N(CC)CC)=S)N(CC)CC
Synonyms

Tetraethylthiuram disulfide; TETD
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	1 year
	-20°C	6 months

Publications (143)

All Cell Proliferation/Viability AssayBio/Physico-chemical AssayWBCell Imaging/StainingIHCIn Vivo Efficacy Study

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Journal Impact Factor

Signal Transduct Target Ther

A20 attenuates oxidized self-DNA-mediated inflammation in acute kidney injury. [Abstract]

2025 Apr 25;10(1):154. PMID: 40280946
Nature

Gasdermin D-mediated metabolic crosstalk promotes tissue repair. [Abstract]

2024 Oct;634(8036):1168-1177. PMID: 39260418
Science

Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae. [Abstract]

2025 Mar 7;387(6738):eadq2509. PMID: 40048515
Cancer Cell

Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance. [Abstract]

2025 Apr 7:S1535-6108(25)00132-1. PMID: 40215978
Cancer Cell

Hypoxia inducible factor-1α drives cancer resistance to cuproptosis. [Abstract]

2025 May 12;43(5):937-954.e9. PMID: 40054467
Cell

Red blood cells undergo lytic programmed cell death involving NLRP3. [Abstract]

2025 May 29;188(11):3013-3029.e19. PMID: 40252640
Cell

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair. [Abstract]

2024 Dec 26;187(26):7533-7550.e23. PMID: 39500322
Nat Cancer

Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling. [Abstract]

2020 Feb;1(2):235-248. PMID: 32613204
Nat Immunol

Purine salvage pathway protects CD8+ T cells from metabolic stress. [Abstract]

2026 May;27(5):1026-1038. PMID: 41974963
Nat Immunol

Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response. [Abstract]

2025 Oct;26(10):1660-1672. PMID: 40954252

Disulfiram purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2025 Oct;26(10):1660-1672. [Abstract]

Wild-type (WT) and Gsdmd^−/− mice were intraperitoneally injected with 15 mg/kg (body weight) LPS and treated with normal saline, SK56 (1 mg/kg (body weight) i.v.) or 50 mg/kg (body weight) DSF, 50 mg/kg (body weight) DMF or 20 mg/kg (body weight) Necrosulfonamide (NSA) i.p. at 16 h after LPS injection. Blood AST, BUN, ALT and CK levels in wild-type and Gsdmd^−/− mice treated as in a at day 2 after LPS injection; n = 6 mice.
Immunity

Gasdermin-D-mediated epithelial-immune circuit synchronizes nutrient absorption and host defense in the small intestine. [Abstract]

2025 Jul 22:S1074-7613(25)00309-7. PMID: 40712560
Bioact Mater

Combination of disulfiram and Copper-Cysteamine nanoparticles induces mitochondria damage and promotes apoptosis in endometrial cancer. [Abstract]

2024 Mar 1:36:96-111. PMID: 38440322

Disulfiram purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Mar 1:36:96-111. [Abstract]

(b) Cytotoxic effects of different concentrations CuCl2, CuCy, and Disulfiram (DSF) (12.5-200 μM) and (c) Combination therapy with different concentrations of CuCy (0.5 μM; 24 h) and DSF (0.5 μM; 24 h) on Ishikawa cells.

Disulfiram purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Mar 1:36:96-111. [Abstract]

Disulfiram (DSF) (0.5 μM; 3-5 h). Vessel formation assay of HUVEC cells after drug treatment.

Disulfiram purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Mar 1:36:96-111. [Abstract]

Disulfiram (DSF) (0.5 μM; 12-24 h). Protein levels of Caspase-9, Caspase-3, Cleaved Caspase-9, and Cleaved Caspase-3 were evaluated by Western blotting after 12 and 24 h of drug treatment.

Disulfiram purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Mar 1:36:96-111. [Abstract]

Disulfiram (DSF) (0.5 μM; 12 h); CuCy (0.5 μM; 12 h). Mitochondrial membrane potential assay and DAPI staining.

Disulfiram purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 Mar 1:36:96-111. [Abstract]

Disulfiram (DSF) (0.5 μM; local injection; once every 3 days, 5 times in total); CuCy (0.5 μM; local injection; once every 3 days, 5 times in total). Results of H&E staining for subcutaneously transplanted tumors and organs (heart, liver, spleen, lung, kidney) in mice. Additionally, TUNEL staining results for the transplanted tumors.
Cell Mol Immunol

The TET3 inflammasome senses unique long HSV-1 proteins for virus particle budding from the nucleus. [Abstract]

2024 Nov;21(11):1322-1334. PMID: 39379602
Cell Mol Immunol

Dextran sodium sulfate potentiates NLRP3 inflammasome activation by modulating the KCa3.1 potassium channel in a mouse model of colitis. [Abstract]

2022 Aug;19(8):925-943. PMID: 35799057
Nat Commun

RIOK2 kinase regulates the translocation of the FADD-RIPK1-Caspase-8 complex to the ER and the cleavage of Gasdermin D to drive pyroptosis. [Abstract]

2025 Nov 17;16(1):10060. PMID: 41249793
Nat Commun

DHRS13 suppresses differentiation and mitophagy in glioma via retinoic acid and mitochondrial reactive oxygen species. [Abstract]

2025 Jul 30;16(1):6996. PMID: 40739132
Nat Commun

Disulfiram ameliorates nonalcoholic steatohepatitis by modulating the gut microbiota and bile acid metabolism. [Abstract]

2022 Nov 11;13(1):6862. PMID: 36369291
Nat Commun

Targeting necroptosis in muscle fibers ameliorates inflammatory myopathies. [Abstract]

2022 Jan 10;13(1):166. PMID: 35013338
Acta Pharm Sin B

Palmitoylated SARM1 targeting P4HA1 promotes collagen deposition and myocardial fibrosis: A new target for anti-myocardial fibrosis. [Abstract]

2025 Sep;15(9):4789-4806. PMID: 41049740
Autophagy

Histone lactylation stimulated upregulation of PSMD14 alleviates neuron PANoptosis through deubiquitinating PKM2 to activate PINK1-mediated mitophagy after traumatic brain injury. [Abstract]

2025 Jul;21(7):1473-1491. PMID: 40000916
Adv Sci (Weinh)

Anthocyanins Prevent Mastitis Exacerbation by Inhibiting PANoptosis Activation. [Abstract]

2025 Jun 24:e07172. PMID: 40552401
Adv Sci (Weinh)

AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple-Negative Breast Cancer. [Abstract]

2025 Feb 20:e2408106. PMID: 39976173
Adv Sci (Weinh)

Enzalutamide Sensitizes Castration-Resistant Prostate Cancer to Copper-Mediated Cell Death. [Abstract]

2024 Jun 10:e2401396. PMID: 38859590
Adv Sci (Weinh)

Inhibition of METTL3 Alleviates NLRP3 Inflammasome Activation via Increasing Ubiquitination of NEK7. [Abstract]

2024 Jul;11(26):e2308786. PMID: 38696610
Chem Eng J

2023 Mar 15.
Sci Adv

Caspase-3/7 deficiency results in enhanced intestinal inflammation and reduced tumorigenesis. [Abstract]

2026 Mar 20;12(12):eadz5906. PMID: 41861024
Small

Intranasal Zinc Oxide Nanoparticles Induce Neuronal PANoptosis via Microglial Pathway. [Abstract]

2025 Mar;21(12):e2408139. PMID: 40012250
Redox Biol

Neutrophil extracellular traps exacerbate inflammatory arthritis by inhibiting γδ Treg cell differentiation via the AIM2 inflammasome. [Abstract]

2025 Sep 30:87:103881. PMID: 41046783
Redox Biol

Deficiency of muscle-generated brain-derived neurotrophic factor causes inflammatory myopathy through reactive oxygen species-mediated necroptosis and pyroptosis. [Abstract]

2024 Nov 8:78:103418. PMID: 39531828
Redox Biol

Lipid peroxidation triggered by the degradation of xCT contributes to gasdermin D-mediated pyroptosis in COPD. [Abstract]

2024 Nov:77:103388. PMID: 39374556
Redox Biol

FAM3A plays a key role in protecting against tubular cell pyroptosis and acute kidney injury. [Abstract]

2024 Jun 8:74:103225. PMID: 38875957
J Hazard Mater

Crystalline silica-induced macrophage pyroptosis interacting with mitophagy contributes to pulmonary fibrosis via modulating mitochondria homeostasis. [Abstract]

2023 Jul 15:454:131562. PMID: 37148789
MedComm (2020)

Dimethyl fumarate alleviate hepatic ischemia-reperfusion injury through suppressing cGAS-STING signaling. [Abstract]

2025 Jan 28;6(2):e70077. PMID: 39877286
Cell Rep Med

Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases. [Abstract]

2024 May 21;5(5):101523. PMID: 38670098
J Exp Med

Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis. [Abstract]

2019 Nov 4;216(11):2562-2581. PMID: 31467036
Environ Int

1,2-Dichloroethane induces testicular pyroptosis by activating piR-mmu-1019957/IRF7 pathway and the protective effects of melatonin. [Abstract]

2024 Feb:184:108480. PMID: 38341879
Environ Int

A potential biomarker of isofenphos-methyl in humans: A chiral view. [Abstract]

2019 Jun;127:694-703. PMID: 30991225
Adv Healthc Mater

Microenvironment-Responsive Cu-MOF Nanoplatform Activates Disulfiram for Synergistic Bacterial Killing and Enhanced Infected Wound Healing. [Abstract]

2025 Oct 15:e03594. PMID: 41097868
Cell Death Dis

ZBP1-mediated PANoptosis is a crucial lethal form in diverse keratinocyte death modalities in UVB-induced skin injury. [Abstract]

2025 Jan 26;16(1):44. PMID: 39863598
Cell Death Dis

Dronedarone hydrochloride (DH) induces pancreatic cancer cell death by triggering mtDNA-mediated pyroptosis. [Abstract]

2024 Oct 2;15(10):725. PMID: 39358349
Proc Natl Acad Sci U S A

Ace2 safeguards embryonic hematopoietic stem and progenitor cell production by restraining Nlrp3-mediated pyroptosis. [Abstract]

2025 Dec 9;122(49):e2515641122. PMID: 41348733
Cell Commun Signal

NLRP3-mediated epithelial pyroptosis involved in airway hyperresponsiveness in combined eosinophilic and neutrophilic asthma. [Abstract]

2026 Jan 31;24(1):144. PMID: 41620621
Acta Pharmacol Sin

Microglial STING activation promotes neuroinflammation and pathological changes in experimental mice with intracerebral haemorrhage. [Abstract]

2025 Apr 8. PMID: 40200123
Acta Pharmacol Sin

KLX ameliorates liver cancer progression by mediating ZBP1 transcription and ubiquitination and increasing ZBP1-induced PANoptosis. [Abstract]

2025 Mar 27. PMID: 40148674
Phytomedicine

Nucleolin inhibits α-synuclein to attenuate aconitine's neurotoxicity. [Abstract]

2025 Jun 2:144:156932. PMID: 40482618
Phytomedicine

Sophflarine A, a novel matrine-derived alkaloid from Sophora flavescens with therapeutic potential for non-small cell lung cancer through ROS-mediated pyroptosis and autophagy. [Abstract]

2023 Jul 25:116:154909. PMID: 37269775
EMBO J

Stearate-derived very long-chain fatty acids are indispensable to tumor growth. [Abstract]

2023 Jan 16;42(2):e111268. PMID: 36408830
Free Radic Biol Med

Dihydroartemisinin targets GPX4 to induce autophagy-dependent ferroptosis and reduce radioresistance in triple-negative breast cancer. [Abstract]

2026 Mar 16:246:35-50. PMID: 41520847
Free Radic Biol Med

PM2.5 exacerbate nonalcoholic fatty liver disease through activating hepatocytes TXNIP/NLRP3/FoxO1 signaling pathway in ob/ob mice. [Abstract]

2025 Dec 18:S0891-5849(25)01443-1. PMID: 41421414
ACS Appl Mater Interfaces

Prolonged Retention of Albumin Nanoparticles Alleviates Renal Ischemia-Reperfusion Injury through Targeted Pyroptosis. [Abstract]

2024 Nov 6;16(44):59921-59933. PMID: 39437799
Am J Transplant

Enhanced autophagy alleviated corneal allograft rejection via inhibiting NLRP3 inflammasome activity. [Abstract]

2022 May;22(5):1362-1371. PMID: 35092164
ACS Environ Au

Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]

2025 Aug 5;5(6):573-582. PMID: 41277996
Brain Behav Immun

Inhibition of GSDMD-dependent pyroptosis decreased methamphetamine self-administration in rats. [Abstract]

2024 Jun 2:120:167-180. PMID: 38834156
Biomed Pharmacother

Systemic cytokines inhibition with Imp7 siRNA nanoparticle ameliorates gut injury in a mouse model of ventilator-induced lung injury. [Abstract]

2023 Sep:165:115237. PMID: 37516020
Oncogene

YTHDC2 inhibits the resistance of lung cancer to EGFR-TKI through cuproptosis. [Abstract]

2025 Dec 16. PMID: 41402633
Cell Death Discov

PDHA1 enhances resistance to ferroptosis in anoikis-resistant prostate cancer by upregulating AIFM2. [Abstract]

2026 Feb 23;12(1):105. PMID: 41724793
Cell Rep

Microglial macrophage-derived ds-HMGB1 in DRG orchestrates neuropathic pain through immune-neural signaling. [Abstract]

2025 Dec 10;44(12):116671. PMID: 41385369
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
Mol Med

Multi-regulatory potency of USP1 on inflammasome components promotes pyroptosis in thyroid follicular cells and contributes to the progression of Hashimoto's thyroiditis. [Abstract]

2024 Aug 12;30(1):121. PMID: 39134949
EMBO Rep

naRNA-LL37 composite DAMPs define sterile NETs as self-propagating drivers of inflammation. [Abstract]

2024 May 23. PMID: 38783164
J Agric Food Chem

Eugenol Alleviates TGEV-Induced Intestinal Injury via Suppressing ROS/NLRP3/GSDMD-Dependent Pyroptosis. [Abstract]

2023 Jan 25;71(3):1477-1487. PMID: 36642968
Ecotoxicol Environ Saf

Polystyrene nanoplastics-induced methuosis in brain microvascular endothelial cells: Rescue via ESCRT membrane repair system. [Abstract]

2025 Aug 8:303:118800. PMID: 40782538
Ecotoxicol Environ Saf

YAP1 protects against PM2.5-induced lung toxicity by suppressing pyroptosis and ferroptosis. [Abstract]

2023 Mar 15:253:114708. PMID: 36863160
Biomater Adv

Folic acid-modified disulfiram/Zn-IRMOF3 nanoparticles for oral cancer therapy by inhibiting ALDH1A1+ cancer stem cells. [Abstract]

2022 Aug:139:213038. PMID: 35908474
Chin Med

Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer. [Abstract]

2022 Sep 29;17(1):115. PMID: 36175965
Biochem Pharmacol

Tanshinone IIA suppresses endoplasmic reticulum stress-mediated IRE1α/TXNIP/NLRP3 pathway to mitigate pyroptosis in type 2 diabetic osteoporosis. [Abstract]

2025 Sep 19;242(Pt 3):117356. PMID: 40976430
Biochem Pharmacol

Ellagic acid mediated pyroptosis in hepatocellular carcinoma via the ESR1/G6PD pathway. [Abstract]

2025 Jul 16:241:117178. PMID: 40680865
Colloids Surf B Biointerfaces

Mannose-modified multifunctional iron-based nanozyme for hepatocellular carcinoma treatment by remodeling the tumor microenvironment. [Abstract]

2025 Feb 3:250:114548. PMID: 39923382
Pharmaceutics

Building of CuO2@Cu-TA@DSF/DHA Nanoparticle Targets MAPK Pathway to Achieve Synergetic Chemotherapy and Chemodynamic for Pancreatic Cancer Cells. [Abstract]

2024 Dec 19;16(12):1614. PMID: 39771592
J Enzyme Inhib Med Chem

Natural product sennoside B disrupts liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein by inhibiting its RNA-binding activity. [Abstract]

2025 Dec;40(1):2501743. PMID: 40371698
J Ethnopharmacol

Astragali radix - Curcumae rhizoma herb pair suppresses hepatocellular carcinoma through EGFR/AKT/mTOR pathway and induces lipid peroxidation-related ferroptosis via HIF-1α/HO-1/GPX4 axis. [Abstract]

2025 Apr 30:119912. PMID: 40316156
Cells

DPP8 Selective Inhibitor Tominostat as a Novel and Broad-Spectrum Anticancer Agent against Hematological Malignancies. [Abstract]

2023 Apr 6;12(7):1100. PMID: 37048172
Life Sci

Phosphate burden induces vascular calcification through a NLRP3-caspase-1-mediated pyroptotic pathway. [Abstract]

2023 Nov 1:332:122123. PMID: 37742736
CNS Neurosci Ther

Downregulation of Mfn2 Contributes to Chronic Postsurgical Pain via Inducing the Pyroptosis of GABAergic Neurons in the Spinal Cord. [Abstract]

2025 Jul;31(7):e70508. PMID: 40631358
Inflammation

Rhaponticin Alleviates Collagen-induced Arthritis by Inhibiting NLRP3/GSDMD-mediated Neutrophil Extracellular Traps. [Abstract]

2024 Dec 27. PMID: 39725843
J Nutr Biochem

Selenium accumulated exposure aggravates the progression of type 2 diabetes mellitus via activating the IRF2/Caspase-4/GSDMD pyroptosis pathway. [Abstract]

2026 Jul:153:110326. PMID: 41734821
PLoS Pathog

Caspase-1-licensed pyroptosis drives dsRNA-mediated necroptosis and dampens host defense against bacterial pneumonia. [Abstract]

2025 May 13;21(5):e1013167. PMID: 40359428
PLoS Pathog

Repurposing alcohol-abuse drug disulfiram for the treatment of KSHV-infected primary effusion lymphoma by activating antiviral innate immunity. [Abstract]

2025 Mar 4;21(3):e1012957. PMID: 40036222
Int J Oncol

Curcumin inhibits the activity of ubiquitin ligase Smurf2 to promote NLRP3‑dependent pyroptosis in non‑small cell lung cancer cells. [Abstract]

2025 Mar;66(3):21. PMID: 39950328
Int J Mol Sci

Disulfiram/Cu Kills and Sensitizes BRAF-Mutant Thyroid Cancer Cells to BRAF Kinase Inhibitor by ROS-Dependently Relieving Feedback Activation of MAPK/ERK and PI3K/AKT Pathways. [Abstract]

2023 Feb 8;24(4):3418. PMID: 36834830
Int J Mol Sci

ATF3/SPI1/SLC31A1 Signaling Promotes Cuproptosis Induced by Advanced Glycosylation End Products in Diabetic Myocardial Injury. [Abstract]

2023 Jan 14;24(2):1667. PMID: 36675183
Int J Mol Sci

Effect of Disulfiram on the Reproductive Capacity of Female Mice. [Abstract]

2023 Jan 25;24(3):2371. PMID: 36768698
PLoS Pathog

COP9 signalosome is an essential and druggable parasite target that regulates protein degradation. [Abstract]

2020 Sep 22;16(9):e1008952. PMID: 32960936
Int Immunopharmacol

Colistin-induced acute kidney injury via zinc Dyshomeostasis-triggered GSDMD-executed Pyroptosis. [Abstract]

2026 Jan 1;168(Pt 1):115768. PMID: 41176907
Int Immunopharmacol

Disulfiram alleviates epithelial barrier disruption in ozone-induced chronic obstructive pulmonary disease mouse models via inhibiting Gasdermin D-mediated pyroptosis. [Abstract]

2025 May 20:159:114887. PMID: 40403507
Eur J Pharmacol

Octreotide attenuates experimental severe acute pancreatitis through inhibiting pyroptosis and modulating intestinal homeostasis. [Abstract]

2025 Feb 6:177314. PMID: 39922420
Int Immunopharmacol

Brucella abortus transcriptional regulator ArsR6 inhibits host pyroptosis via BAB_RS28760 by triggering the endoplasmic reticulum stress pathway. [Abstract]

2025 Jan 8:147:114001. PMID: 39787758
Int Immunopharmacol

Dapagliflozin attenuates skeletal muscle atrophy in diabetic nephropathy mice through suppressing Gasdermin D-mediated pyroptosis. [Abstract]

2025 Jan 20:148:114088. PMID: 39837016
Int Immunopharmacol

Hesperetin alleviates PM2.5-induced lung injury by inhibiting ferroptosis in an Nrf2-dependent manner. [Abstract]

2025 Jan 29:148:114123. PMID: 39884081
Cell Regen

METTL3 restricts RIPK1-dependent cell death via the ATF3-cFLIP axis in the intestinal epithelium. [Abstract]

2024 Aug 2;13(1):14. PMID: 39093347
Int Immunopharmacol

Disulfiram mediated anti-tumour effect in pituitary neuroendocrine tumours by inducing cuproptosis. [Abstract]

2024 Jun 15:134:112159. PMID: 38692018
Int Immunopharmacol

Extracellular ATP contributes to the reactive oxygen species burst and exaggerated mitochondrial damage in D-galactosamine and lipopolysaccharide-induced fulminant hepatitis. [Abstract]

2024 Mar 30:130:111680. PMID: 38368772
Eur J Pharmacol

Overcoming the compensatory increase in NRF2 induced by NPL4 inhibition enhances disulfiram/copper-induced oxidative stress and ferroptosis in renal cell carcinoma. [Abstract]

2023 Dec 5:960:176110. PMID: 37838104
Hepatol Commun

Gasdermin D-mediated pyroptosis suppresses liver regeneration after 70% partial hepatectomy. [Abstract]

2022 Sep;6(9):2340-2353. PMID: 35509206
Cell Rep Methods

RECOVER identifies synergistic drug combinations in vitro through sequential model optimization. [Abstract]

2023 Oct 23;3(10):100599. PMID: 37797618
J Infect Dis

Role of Histiocyte-Derived frHMGB1 as a Facilitator in Non-Canonical Pyroptosis of Monocytes/Macrophages in Lethal Sepsis. [Abstract]

2024 Aug 16;230(2):298-308. PMID: 38243905
Mol Oncol

Downregulation of RCN1 promotes pyroptosis in acute myeloid leukemia cells. [Abstract]

2023 Dec;17(12):2584-2602. PMID: 37746742
Cancers (Basel)

Drug Repurposing to Identify a Synergistic High-Order Drug Combination to Treat Sunitinib-Resistant Renal Cell Carcinoma. [Abstract]

2021 Aug 6;13(16):3978. PMID: 34439134
FASEB J

Penicillide Triggers Immunogenic Pyroptosis in Tumor Cells via Oxidative Stress/NF-κB/GSDMD Signaling Axis. [Abstract]

2026 Mar 31;40(6):e71636. PMID: 41842655
Biochim Biophys Acta Mol Basis Dis

PDIA4 targets IRE1α/sXBP1 to alleviate NLRP3 inflammasome activation and renal tubular injury in diabetic kidney disease. [Abstract]

2024 Dec 30:167645. PMID: 39743023
iScience

Development of retinoid nuclear receptor pathway antagonists through targeting aldehyde dehydrogenase 1A3. [Abstract]

2025 Oct 3;28(11):113675. PMID: 41210994
J Inflamm Res

Neutrophil Extracellular Traps Induce Alveolar Macrophage Pyroptosis by Regulating NLRP3 Deubiquitination, Aggravating the Development of Septic Lung Injury. [Abstract]

2023 Feb 27:16:861-877. PMID: 36876152
J Inflamm Res

Calcitriol Alleviates Hyperosmotic Stress-Induced Corneal Epithelial Cell Damage via Inhibiting the NLRP3-ASC-Caspase-1-GSDMD Pyroptosis Pathway in Dry Eye Disease. [Abstract]

2021 Jul 5:14:2955-2962. PMID: 34262321
Sci Rep

Cysteine-reactive mitigators of small vessel disease-related NOTCH3 mutants. [Abstract]

2026 Mar 20;16(1):14300. PMID: 41862552
Sci Rep

Disulfiram attenuates immobilization-induced knee joint contracture by suppressing Caspase-1/GSDMD-mediated pyroptosis. [Abstract]

2026 Mar 9;16(1):12779. PMID: 41803228
J Biotechnol

FRET two-hybrid assay-based target drug screening in living cells. [Abstract]

2025 Nov 12:410:1-9. PMID: 41238124
ACS Chem Neurosci

Calycosin Inhibit PANoptosis and Alleviate Brain Damage: A Bioinformatics and Experimental Verification Approach. [Abstract]

2025 Apr 16;16(8):1550-1564. PMID: 40156525
Lung

Disulfiram Alleviates MTX-Induced Pulmonary Fibrosis by Inhibiting EMT in Type 2 Alveolar Epithelial Cells. [Abstract]

2024 Nov 27;203(1):4. PMID: 39601871
Biomedicines

Icaritin Exerts Anti-Cancer Effects through Modulating Pyroptosis and Immune Activities in Hepatocellular Carcinoma. [Abstract]

2024 Aug 21;12(8):1917. PMID: 39200381
Aesthet Surg J

Disulfiram Improves Fat Graft Retention by Modulating Macrophage Polarization With Inhibition of NLRP3 Inflammasome-Mediated Pyroptosis. [Abstract]

2024 Jun 14;44(7):NP501-NP518. PMID: 38567442
J Biol Chem

SLC25A3 negatively regulates NLRP3 inflammasome activation by restricting the function of NLRP3. [Abstract]

2024 May;300(5):107233. PMID: 38552738
Aging (Albany NY)

Disulfiram suppressed ethanol promoted RANKL-induced osteoclastogenesis in vitro and ethanol-induced osteoporosis in vivo via ALDH1A1-NFATc1 axis. [Abstract]

2019 Oct 8;11(19):8103-8119. PMID: 31596733
Exp Cell Res

Fetuin B drives metabolism-associated steatohepatitis by promoting hepatocyte pyroptosis via NLRP3/GSDMD pathway. [Abstract]

2026 Jan 6;456(1):114886. PMID: 41506566
Toxicol Appl Pharmacol

Andrographolide-induced PANoptosis underlies its multiple organ toxicity in mice. [Abstract]

2025 Dec 8:507:117682. PMID: 41371369
Acta Biochim Biophys Sin (Shanghai)

Induction of multiple subroutines of regulated necrosis in murine macrophages by natural BH3-mimetic gossypol. [Abstract]

2022 Jan 25;54(1):64-76. PMID: 35130622
Pathogens

Extracellular Lipopolysaccharide Triggers the Release of Unconjugated Interferon-Stimulated Gene 15 (ISG15) Protein from Macrophages via Type-I Interferon/Caspase-4/Gasdermin-D Pathway. [Abstract]

2026 Jan 22;15(1):122. PMID: 41599106
J Inorg Biochem

Iridium(III) complexes as type I photosensitizers for hypoxic two-photon photodynamic therapy. [Abstract]

2025 Nov:272:113006. PMID: 40682924
Naunyn Schmiedebergs Arch Pharmacol

Integration of network pharmacology and transcriptomics to reveal the ROS/NLRP3/Caspase-1/GSDMD-mediated mechanism of baicalin in alleviating contrast-induced acute kidney injury. [Abstract]

2025 Dec 12. PMID: 41384955
Cardiovasc Drugs Ther

Disulfiram protects against abdominal aortic aneurysm by ameliorating vascular smooth muscle cells pyroptosis. [Abstract]

2023 Dec;37(6):1-14. PMID: 35723784
Curr Issues Mol Biol

Cucurbitacin B Inhibits Hepatocellular Carcinoma by Inducing Ferroptosis and Activating the cGAS-STING Pathway. [Abstract]

2026 Jan 27;48(2):138. PMID: 41751402
Mol Immunol

Hyperactivation of succinate dehydrogenase promotes pyroptosis of macrophage via ROS-induced GSDMD oligomerization in acute liver failure. [Abstract]

2024 May:169:86-98. PMID: 38552285
Oral Dis

Repurposing disulfiram to induce OSCC cell death by cristae dysfunction promoted autophagy. [Abstract]

2021 Jul;27(5):1148-1160. PMID: 32989819
J Biochem Mol Toxicol

Caspase-1 Dependent Neutrophil Pyroptosis Contributes to Fine Particulate Matter-Induced Lung Inflammation. [Abstract]

2025 Dec;39(12):e70639. PMID: 41416635
Int J Biochem Cell Biol

Cofilin is a key regulator of oxidative stress-induced intercellular tunneling nanotubes formation. [Abstract]

2025 Jun 9:186:106820. PMID: 40499810
SLAS Discov

A Novel Flow Cytometric Assay to Identify Inhibitors of RBPJ-DNA Interactions. [Abstract]

2020 Sep;25(8):895-905. PMID: 32567455
Cancer Manag Res

Disulfiram inhibits epithelial-mesenchymal transition through TGFβ-ERK-Snail pathway independently of Smad4 to decrease oral squamous cell carcinoma metastasis. [Abstract]

2019 May 1:11:3887-3898. PMID: 31118804
Exp Ther Med

Pulmonary artery smooth muscle cell pyroptosis promotes the proliferation of PASMCs by paracrine IL‑1β and IL‑18 in monocrotaline‑induced pulmonary arterial hypertensive rats. [Abstract]

2024 Aug 7;28(4):394. PMID: 39171148
Biochem Biophys Res Commun

Human cytomegalovirus protein US18 promotes NLRP3 inflammasome activation. [Abstract]

2025 May 28:775:152110. PMID: 40450990
J Coord Chem

2025 Nov 12.
Int Heart J

Exploring the Role and Mechanism of DSF in HFpEF Based on IL-1β/IL-1βR/TAK1/RIPK1 Axis-Mediated PANoptosis. [Abstract]

2026;67(1):65-76. PMID: 41621910
bioRxiv

2026 May 26.
bioRxiv

2026 Feb 2.
University of Wolverhampton

2025.
SSRN

2024 Jun 18.
SSRN

2023 Nov 8.
SSRN

2023 Sep 22.
Research Square Preprint

2023 Aug 5.
Phytomedicine Plus

11 October 2022, 100364.
Oxid Med Cell Longev

lncRNA ZFAS1 Positively Facilitates Endothelial Ferroptosis via miR-7-5p/ACSL4 Axis in Diabetic Retinopathy. [Abstract]

2022 Aug 31;2022:9004738. PMID: 36092160
bioRxiv

May 10, 2022.
Research Square Preprint

2022 May.
bioRxiv

2020 Jun.
Patent

US20180263995A1.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 75 mg/mL (252.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.3722 mL

16.8611 mL

33.7223 mL

5 mM

0.6744 mL

3.3722 mL

6.7445 mL

10 mM

0.3372 mL

1.6861 mL

3.3722 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (7.01 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (7.01 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (7.01 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: Corn Oil

Solubility: 30 mg/mL (101.17 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Protokoll

Cell Assay^[4]

The effect of disulfiram (0.15-5.0 μM) or sodium diethyldithiocarbamate (1.0 μM) on proliferation of malignant cell lines is studied in cultures stimulated with 10% FBS. Cell numbers are quantitated 24 to 72 hours later, as outlined below. In some experiments, disulfiram is added immediately after cells are plated. In other experiments, cells are plated and allowed to grow for 24 to 72 hours before fresh medium with disulfiram is added and cell numbers are assayed 24 to 72 hours later. Synergy is studied between disulfiram and N,N′-bis(2-chloroethyl-N-nitrosourea (carmustine, 1.0-1,000 μM) or cisplatin (0.1-100 μg/mL) added to medium. The effect of metal ions on disulfiram is studied with 0.2 to 10 μM Cu²⁺ (provided as CuSO₄), Zn²⁺ (as ZnCl₂), Ag⁺ (as silver lactate), or Au³⁺ (as HAuCl₄·3H₂O) ions added to growth medium, buffered to physiologic pH. To provide a biologically relevant source of copper, medium is supplemented with human ceruloplasmin at doses replicating low and high normal adult serum concentrations (250 and 500 mg/mL).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration^[4]

Adult female CB17-SCID mice are housed in a protected laminar flow facility with access to water and either a standard diet containing 87 ppm zinc or a zinc-supplemented diet containing 1,000 ppm Zn²⁺ as zinc acetate. Mice are injected s.c. in the right groin with 5×10⁶ cells from a highly aggressive malignant melanoma obtained from a Carolinas Medical Center patient. The frozen tumor is passaged twice in SCID mice to adapt it to in vivo growth before use in these experiments. On the day of tumor injection, all mice began daily administration of drug. Drug is given in a total volume of 0.2 mL by gastric gavage via smooth Teflon-tipped needles inserted transorally into the stomach. Four groups are studied: tumor control (n=10; 0.2 mL olive oil daily; zinc diet of 87 ppm); zinc-supplemented control (n=10; 0.2 mL olive oil daily; zinc diet of 1,000 ppm); disulfiram (n=10; 200 mg/kg/d disulfiram in 0.2 mL olive oil; zinc diet of 87 ppm); and zinc-supplemented diet + disulfiram (n=10; 200 mg/kg/d disulfiram in 0.2 mL olive oil; zinc diet of 1,000 ppm). Mice are examined daily, the tumor is measured in two dimensions, and the tumor volume is estimated using the formula for an elipse. When estimated tumor volume approached 500 mm³ within any animal, all mice are euthanized. Tumors are excised, weighed, fixed in formalin, sectioned, and stained or immunostained for factor VIII. Slides are coded and examined by a blinded observer who identified vessels as deposits of red cells. For each slide, the number of vessels is counted in four different fields representative of the tumor. The average number of vessels per field is averaged per biopsy specimen and used to evaluate tumor vascularity.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (764 KB)
- English - EN (764 KB)
- Français - FR (764 KB)
- Deutsch - DE (764 KB)
- Norwegian - NO (764 KB)
- Español - ES (764 KB)
- Swedish - SV (764 KB)
- Italian - IT (764 KB)
- Portuguese - PT (764 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chen D, ert al. Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and?xenografts?via?inhibition?of the proteasome?activity. Cancer Res. 2006 Nov 1;66(21):10425-33. [Content Brief]

[2]. Wang W, et al. Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines. Int J Cancer. 2003 Apr 20;104(4):504-11. [Content Brief]

[3]. Cen D, et al. Disulfiram facilitates intracellular Cu uptake and induces apoptosis in human melanoma cells. J Med Chem. 2004 Dec 30;47(27):6914-20. [Content Brief]

[4]. Brar SS, et al. Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease. Mol Cancer Ther. 2004 Sep;3 [Content Brief]

[5]. Jun Jacob Hu, et al. Identification of pyroptosis inhibitors that target a reactive cysteine in gasdermin D. The Preprint Server For Biology, 2018,Jul. 10.

[6]. Guo F, et, al. Inhibitory effect on ovarian cancer ALDH+ stem-like cells by Disulfiram and Copper treatment through ALDH and ROS modulation. Biomed Pharmacother. 2019 Oct;118:109371. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.3722 mL	16.8611 mL	33.7223 mL	84.3057 mL
	5 mM	0.6744 mL	3.3722 mL	6.7445 mL	16.8611 mL
	10 mM	0.3372 mL	1.6861 mL	3.3722 mL	8.4306 mL
	15 mM	0.2248 mL	1.1241 mL	2.2482 mL	5.6204 mL
	20 mM	0.1686 mL	0.8431 mL	1.6861 mL	4.2153 mL
	25 mM	0.1349 mL	0.6744 mL	1.3489 mL	3.3722 mL
	30 mM	0.1124 mL	0.5620 mL	1.1241 mL	2.8102 mL
	40 mM	0.0843 mL	0.4215 mL	0.8431 mL	2.1076 mL
	50 mM	0.0674 mL	0.3372 mL	0.6744 mL	1.6861 mL
	60 mM	0.0562 mL	0.2810 mL	0.5620 mL	1.4051 mL
	80 mM	0.0422 mL	0.2108 mL	0.4215 mL	1.0538 mL
	100 mM	0.0337 mL	0.1686 mL	0.3372 mL	0.8431 mL

Keywords

Disulfiram

143 Cited Publications

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Disulfiram

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

FDA-Approved Drug Library

Anti-Cancer Compound Library

CNS-Penetrant Compound Library

Drug Repurposing Compound Library

Differentiation Inducing Compound Library

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Pyroptosis Compound Library

Orally Active Compound Library

Glutamine Metabolism Compound Library

FDA Approved & Pharmacopeial Drug Library

Anti-Breast Cancer Compound Library

Drug-Induced Liver Injury (DILI) Compound Library

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FDA-Approved Anticancer Drug Library

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Publications Citing Use of MedChemExpress (MCE) Disulfiram

Alle Aldehyde Dehydrogenase (ALDH) Isoform-spezifische Produkte anzeigen

Alle Interleukin Related Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (143)

Lösungsmittel & Löslichkeit

Protokoll

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Disulfiram Related Classifications

Art. -Nr.: HY-B0240