Erufosine
Erufosine is an inhibitor of PI3K/Akt and Ras/Raf/MAPK signaling pathways. Erufosine inhibits the activity of breast cancer cell lines MCF-7 and MDA-MB 231 (IC50: 40.95/40.8 μM). Erufosine reduces the phosphorylation of PI3K (p85), Akt (PKB), and cRaf. Erufosine can be used in the study of breast cancer and myeloid leukemia.
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- CAS. Nr.: 202867-33-2
- Formel: C28H58NO4P
- Molecular Weight:503.74
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | CC50 |
28 μM
Compound: Erufosine
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Cytotoxicity against human HEK293T cells assessed as cell death by measuring metabolism of resazurin to resorufin measured after 3 days
Cytotoxicity against human HEK293T cells assessed as cell death by measuring metabolism of resazurin to resorufin measured after 3 days
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[PMID: 36827952] |
| THP-1 | CC50 |
2 μM
Compound: Erufosine
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Cytotoxicity against human THP-1 cells assessed as cell death by measuring metabolism of resazurin to resorufin measured after 3 days
Cytotoxicity against human THP-1 cells assessed as cell death by measuring metabolism of resazurin to resorufin measured after 3 days
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[PMID: 36827952] |
Chemical Information
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CAS. Nr. 202867-33-2
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Molecular Weight 503.74
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Formel C28H58NO4P
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SMILES
CCCCCCCC/C=C\CCCCCCCCCCCCOP(OCCC[N+](C)(C)C)([O-])=O
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Synonyms
ErPC3; Erucylphosphohomocholine
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Erufosine Related Classifications
HY-171777 Related Classifications
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