Art. -Nr.: HY-118065

Fenhexamid

(Synonyms: KBR 2738)

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Fenhexamid, a botryticide, is a sterol biosynthesis inhibitor. Fenhexamid shows fungicide efficient against the plant pathogenic fungus Botryotinia fuckeliana (Botrytis cinerea).

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Reinheit: 99.60%
CAS. Nr.: 126833-17-8
Formel: C₁₄H₁₇Cl₂NO₂
Molecular Weight:302.20

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Fenhexamid Chemical Structure

CAS. Nr.: 126833-17-8

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Fenhexamid, a botryticide, is a sterol biosynthesis inhibitor. Fenhexamid shows fungicide efficient against the plant pathogenic fungus Botryotinia fuckeliana (Botrytis cinerea)^[1].

Alle PI3K Isoform-spezifische Produkte anzeigen :

Alle Estrogen Receptor/ERR Isoform-spezifische Produkte anzeigen :

In Vitro

Fenhexamid (0.1-10 μM, 24 h-9 days) is the agonist for ERα with EC₅₀ of 9 μM. Fenhexamid enhances the proliferation and migration of ovarian cancer cell BG-1, promotes the expression of cyclin D1 and cathepsin D^[2]^[3].
Fenhexamid (0.1-10 μM, 4 h) promotes angiogenesis of HUVEC cells and increases the expression of VEGF through activation of PI3K signaling pathway^[3].
Fenhexamid (0.1-10 μM, 4 h) promotes the EMT process of ER-positive MCF-7 cells, reducse the expression of E-cadherin and Occludin, and increases the expression of N-cadherin and Vimentin^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:

BG-1
Concentration:

0.1-10 μM
Incubation Time:

9 days
Result:

Promoted the cell proliferation.

Western Blot Analysis^[2]

Cell Line:

BG-1
Concentration:

0.1-10 μM
Incubation Time:

24 h
Result:

Upregulated the expression of cyclin D1 and cathepsin D.

In Vivo

Fenhexamid (20 mg/kg, ip, every 3 days for 80 days) exhibits no effect on tumor growth in BG-1 xenograft mouse models, but exhibits toxicity in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BG-1 xenograft mouse models^[2]
Dosage:

20 mg/kg
Administration:

ip, every 3 days for 80 days
Result:

Caused mouse death within 60 days.

Chemical Information

CAS. Nr. 126833-17-8
Appearance Solid
Molecular Weight 302.20
Formel C₁₄H₁₇Cl₂NO₂
Color Off-white to light yellow
SMILES

O=C(NC1=CC=C(C(Cl)=C1Cl)O)C2(CCCCC2)C
Synonyms

KBR 2738
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (330.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.3091 mL

16.5453 mL

33.0907 mL

5 mM

0.6618 mL

3.3091 mL

6.6181 mL

10 mM

0.3309 mL

1.6545 mL

3.3091 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (458 KB)
- English - EN (458 KB)
- Français - FR (458 KB)
- Deutsch - DE (458 KB)
- Norwegian - NO (458 KB)
- Español - ES (458 KB)
- Swedish - SV (458 KB)
- Italian - IT (458 KB)
- Korean - KR (458 KB)
- Portuguese - PT (458 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Debieu D, et al. The hydroxyanilide fenhexamid, a new sterol biosynthesis inhibitor fungicide efficient against the plant pathogenic fungus Botryotinia fuckeliana (Botrytis cinerea). Pest Manag Sci. 2001 Nov;57(11):1060-7. [Content Brief]

[2]. Go RE, et al., Effect of fenhexamid and cyprodinil on the expression of cell cycle- and metastasis-related genes via an estrogen receptor-dependent pathway in cellular and xenografted ovarian cancer models. Toxicol Appl Pharmacol. 2015 Nov 15;289(1):48-57. [Content Brief]

[3]. Medjakovic S, et al., Effect of nonpersistent pesticides on estrogen receptor, androgen receptor, and aryl hydrocarbon receptor. Environ Toxicol. 2014 Oct;29(10):1201-16. [Content Brief]

[4]. Go RE, et al., A fungicide, fenhexamid, is involved in the migration and angiogenesis in breast cancer cells expressing estrogen receptors. Life Sci. 2022 Sep 15;305:120754. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.3091 mL	16.5453 mL	33.0907 mL	82.7267 mL
	5 mM	0.6618 mL	3.3091 mL	6.6181 mL	16.5453 mL
	10 mM	0.3309 mL	1.6545 mL	3.3091 mL	8.2727 mL
	15 mM	0.2206 mL	1.1030 mL	2.2060 mL	5.5151 mL
	20 mM	0.1655 mL	0.8273 mL	1.6545 mL	4.1363 mL
	25 mM	0.1324 mL	0.6618 mL	1.3236 mL	3.3091 mL
	30 mM	0.1103 mL	0.5515 mL	1.1030 mL	2.7576 mL
	40 mM	0.0827 mL	0.4136 mL	0.8273 mL	2.0682 mL
	50 mM	0.0662 mL	0.3309 mL	0.6618 mL	1.6545 mL
	60 mM	0.0552 mL	0.2758 mL	0.5515 mL	1.3788 mL
	80 mM	0.0414 mL	0.2068 mL	0.4136 mL	1.0341 mL
	100 mM	0.0331 mL	0.1655 mL	0.3309 mL	0.8273 mL

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Fenhexamid

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Alle PI3K Isoform-spezifische Produkte anzeigen

Alle Estrogen Receptor/ERR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Fenhexamid Related Classifications

HY-118065 Related Classifications