Art. -Nr.: HY-W984782

Flindersine

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Flindersine is an alkaloid with multiple activities including antibacterial, antifungal, antitumor, and antidiabetic properties. Flindersine increases the activity of antioxidant enzymes, restores the levels of renal biomarkers, and reduces blood glucose, blood lipid, and insulin levels in diabetic rats. Flindersine inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, drug-resistant bacteria, as well as dermatophytes, filamentous fungi, and yeasts. Flindersine reduces the viability of cancer cells and induces apoptosis. Flindersine can be used in research related to breast cancer, type 2 diabetes, bacterial infections, and fungal infections.

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Reinheit: 99.80%
CAS. Nr.: 523-64-8
Formel: C₁₄H₁₃NO₂
Molecular Weight:227.26

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Flindersine Chemical Structure

CAS. Nr.: 523-64-8

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

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In Vitro

Flindersine (50-200 μM; 24 h) reduces the viability of MDA-MB-231 and MCF-7 human breast cancer cells in a dose-dependent manner (with stronger efficacy against MDA-MB-231 cells), but has no effect on the viability of HUVEC^[1].
Flindersine (50-200 μM; 24 h) dose-dependently downregulates the protein expression of GLUT1, HK2 and LDHA in MDA-MB-231 and MCF-7 human breast cancer cells, with a stronger efficacy in MDA-MB-231 cells^[1].
Flindersine (50-200 μM; 24 h) dose-dependently reduces LDHA enzyme activity, intracellular ATP production, glucose uptake, and lactate production in MDA-MB-231 and MCF-7 human breast cancer cells, with greater potency in MDA-MB-231 cells^[1].
Flindersine (50-200 μM; 24 h) dose-dependently induces apoptosis in human breast cancer cell lines MDA-MB-231 and MCF-7, with stronger efficacy against MDA-MB-231 cells^[1].
Flindersine (24 h) exhibits moderate in vitro antibacterial activity against Gram-positive bacteria Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Gram-negative bacterium Pseudomonas aeruginosa, and drug-resistant bacterium Acinetobacter baumannii, with MIC values ranging from 31.25 to 250 μg/mL, but shows no activity against most other tested Gram-negative bacteria and drug-resistant bacteria^[2].
Flindersine (0-9 days) exhibits moderate in vitro antifungal activity against the dermatophytes Trichophyton mentagrophytes, Trichophyton simii, Trichophyton rubrum 57, Epidermophyton floccosum, Trichophyton rubrum 296, the filamentous fungus Magnaporthe grisea, and the yeast Candida albicans, with MIC values ranging from 62.5 to 250 μg/mL, but shows no activity against other tested fungi^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MDA-MB-231, MCF-7
Concentration:

50, 100, 200 μM
Incubation Time:

24 h
Result:

Dose-dependently suppressed GLUT1, HK2, and LDHA protein expression by 20-80% in MDA-MB-231 cells compared to control.
Reduced GLUT1 expression by 65% in MDA-MB-231 cells at 200 μM.
Reduced GLUT1 expression by 65% in MCF-7 cells at 200 μM.
Dose-dependently reduced HK2 and LDHA expression by 25-65% in MCF-7 cells compared to control.
Exerted greater effects on reducing glycolytic protein expression in MDA-MB-231 cells than in MCF-7 cells.

Apoptosis Analysis^[1]

Cell Line:

MDA-MB-231, MCF-7
Concentration:

50, 100, 200 μM
Incubation Time:

24 h
Result:

Increased the percentage of apoptotic cells from 4.25% (control) to 15.81%, 29.5%, and 43.6% in MDA-MB-231 cells at 50, 100, and 200 μM respectively.
Increased the percentage of apoptotic cells from 2.1% (control) to 12.41%, 20.32%, and 34.1% in MCF-7 cells at 50, 100, and 200 μM respectively.

In Vivo

Flindersine (20-40 mg/kg; daily administration; for 28 consecutive days) exhibits potent antidiabetic, lipid-regulating and antioxidant activities in high-fat diet-Streptozotocin (HY-13753)-induced type 2 diabetic rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar (male, 180-200 g, high-fat diet + streptozotocin-induced type 2 diabetes)^[3]
Dosage:

10 mg/kg; 20 mg/kg; 40 mg/kg
Administration:

daily; 28 days
Result:

Lowered blood glucose levels.
Reduced final body weight gain, plasma insulin levels, AST, ALT, ALP, urea, creatinine, total cholesterol, triglycerides, and free fatty acid levels.
Increased total protein levels, SOD activity.
Increased CAT and GPx activities.
Increased GLUT4, AMPK, and PPARγ mRNA and protein expression in adipose tissue and skeletal muscles.

Chemical Information

CAS. Nr. 523-64-8
Appearance Solid
Molecular Weight 227.26
Formel C₁₄H₁₃NO₂
Color Off-white to light yellow
SMILES

O=C1NC2=C(C3=C1C=CC(C)(C)O3)C=CC=C2
Structure Classification
- Alkaloids
- Quinoline Alkaloids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (440.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.4002 mL

22.0012 mL

44.0025 mL

5 mM

0.8800 mL

4.4002 mL

8.8005 mL

10 mM

0.4400 mL

2.2001 mL

4.4002 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Moghtaderi H, et al. Flindersine from Haplophyllum tuberculatum modulates glycolysis and promotes apoptosis in breast cancer: Insights from in vitro, electrochemical, and molecular docking studies. Pharmacological Research-Natural Products, 2025: 100427.

[2]. Duraipandiyan V, et al. Antibacterial and antifungal activity of Flindersine isolated from the traditional medicinal plant, Toddalia asiatica (L.) Lam. J Ethnopharmacol. 2009;123(3):494-498. [Content Brief]

[3]. Irudayaraj SS, et al. Antidiabetic with antilipidemic and antioxidant effects of flindersine by enhanced glucose uptake through GLUT4 translocation and PPARγ agonism in type 2 diabetic rats. J Ethnopharmacol. 2022;285:114883. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.4002 mL	22.0012 mL	44.0025 mL	110.0062 mL
	5 mM	0.8800 mL	4.4002 mL	8.8005 mL	22.0012 mL
	10 mM	0.4400 mL	2.2001 mL	4.4002 mL	11.0006 mL
	15 mM	0.2933 mL	1.4667 mL	2.9335 mL	7.3337 mL
	20 mM	0.2200 mL	1.1001 mL	2.2001 mL	5.5003 mL
	25 mM	0.1760 mL	0.8800 mL	1.7601 mL	4.4002 mL
	30 mM	0.1467 mL	0.7334 mL	1.4667 mL	3.6669 mL
	40 mM	0.1100 mL	0.5500 mL	1.1001 mL	2.7502 mL
	50 mM	0.0880 mL	0.4400 mL	0.8800 mL	2.2001 mL
	60 mM	0.0733 mL	0.3667 mL	0.7334 mL	1.8334 mL
	80 mM	0.0550 mL	0.2750 mL	0.5500 mL	1.3751 mL
	100 mM	0.0440 mL	0.2200 mL	0.4400 mL	1.1001 mL

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Flindersine

Anti-Infection Compound Library

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Immunology/Inflammation Compound Library

Membrane Transporter/Ion Channel Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

PI3K/Akt/mTOR Compound Library

Natural Product Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Anti-diabetic Compound Library

Oxygen Sensing Compound Library

Antifungal Compound Library

Antibacterial Compound Library

Glycolysis Compound Library

Cytoskeleton Compound Library

Glutamine Metabolism Compound Library

Alkaloids Library

Anti-Pancreatic Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Transcription Factor-Targeted Library

Lipid Metabolism Compound Library

Glucose Metabolism Compound Library

Anti-Cancer Natural Product Library

Plant-Sourced Natural Product Library

Nuclear Receptor Compound Library

Pain-Related Compound Library

Metabolic Enzyme Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cell Death Library

Anti-Drug-Resistant Compound Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Anti-Fibrosis Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

Alle GLUT Isoform-spezifische Produkte anzeigen

Alle AMPK Isoform-spezifische Produkte anzeigen

Alle PPAR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Flindersine Related Classifications

HY-W984782 Related Classifications