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Art. -Nr.: HY-10617AS1

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Rucaparib-d₃

(Synonyms: AG014699-d₃; PF-01367338-d₃)

Rucaparib-d₃ (AG014699-d₃) is the deuterated -labeled Rucaparib (HY-10617A). Rucaparib (AG014699) is an orally active, potent inhibitor of PARP proteins (PARP-1, PARP-2 and PARP-3) with a K_i of 1.4 nM for PARP1. Rucaparib is a modest hexose-6-phosphate dehydrogenase (H6PD) inhibitor. Rucaparib has the potential for castration-resistant prostate cancer (CRPC) research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2271225-13-7
Formel: C₁₉H₁₅D₃FN₃O
Molecular Weight:326.38

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Rucaparib-d₃ Chemical Structure

CAS. Nr.: 2271225-13-7

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
- Anwendung
Chemical Information
Reinheit & Dokumentation
Calculators
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Bioz

Biologische Aktivität

Beschreibung

Alle PARP Isoform-spezifische Produkte anzeigen :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Animal Model:

Female CD-1 nude mice aged 10-12 weeks with Capan-1 cells^[2]
Dosage:

10 mg/kg for i.p. or 50, 150 mg/kg for p.o.
Administration:

IP or PO
Result:

Significantly inhibited the growth of the tumor.

Anwendung

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS. Nr. 2271225-13-7
Unlabeled Cas 283173-50-2
Molecular Weight 326.38
Formel C₁₉H₁₅D₃FN₃O
SMILES

O=C1C2=C3C(CCN1)=C(C4=CC=C(C=C4)CNC([2H])([2H])[2H])NC3=CC(F)=C2
Synonyms

AG014699-d₃; PF-01367338-d₃
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.