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Fenofibrate

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Based on 35 publication(s) in Google Scholar

Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC50s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.

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  • Pureté: 99.97%
  • CAS No.: 49562-28-9
  • Formule: C20H21ClO4
  • Masse moléculaire:360.83
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Fenofibrate Chemical Structure
    Fenofibrate Chemical Structure
  • Experimental Validation Results for Fenofibrate
  • Experimental Validation Results for Fenofibrate
  • Experimental Validation Results for Fenofibrate
  • Experimental Validation Results for Fenofibrate
  • Experimental Validation Results for Fenofibrate
CAS No.: 49562-28-9
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  • Fenofibrate Chemical Structure
    Fenofibrate Chemical Structure
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    Fenofibrate purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Oct 22:S1550-4131(25)00396-1. [Abstract]

    Customer Validation
     Acyl-CoA relative levels in mouse primary hepatocytes after 4 or 24 h treatment of 326E (100 μM) and Fenofibrate (100 μM).

  • 1/16

    Fenofibrate purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Oct 22:S1550-4131(25)00396-1. [Abstract]

    Customer Validation
     After 7-day oral treatment with Fenofibrate (40 mg/kg, calculated based on clinical dose), SB204990 (150 mg/kg), SB204990 (150 mg/kg) plus fenofibrate(40 mg/kg), BA (30 mg/kg), or 326E (30 mg/kg) in MASH mice (induced by Gan diet or CDAA-HFD), hepatic DNL was assessed by 14C-acetate tracing.

  • 1/16

    Fenofibrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr 15:e2415846. [Abstract]

    Customer Validation
     After treatment with asprosin overexpression plasmid for 24 h, primary hepatocytes were treated with Fenofibrate (100 μM) for 24 h. The protein level of PPARα was analyzed by Western blot.

  • 1/16

    Fenofibrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr 15:e2415846. [Abstract]

    Customer Validation
     C57BL/6 J mice were fed on HFCDAA and treated with the indicated AAVs. After C57BL/6 J mice were fed on HFCDAA for 4 weeks, mice were injected with vehicle or Fenofibrate (100 mg/kg) for 4 weeks.

  • 1/16

    Fenofibrate purchased from MedChemExpress. Usage Cited in: Hepatology. 2018 Jul;68(1):289-303. [Abstract]

    Customer Validation
     PAQR3 modulates fatty acid oxidation in hepatocytes. The cells in panel A were treated with WY14643 (30 lM) or Fenofibrate (50 lM) for 24 hours, followed by measurement of the fatty acid oxidation rate.

  • Fenofibrate