AG-12286
AG-12286 is a pan-CDK inhibitor with an IC50 value of 2 nM against cdk1/cyclin B, 6 nM against cdk2/cyclin E, and 12 nM against cdk4/cyclin D. AG-12286 is 1000-fold more selective for the CDK family than for PKC. AG-12286 can be used in cancer research.
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- CAS No.: 223784-75-6
- Formule: C16H12F2N4O3S2
- Masse moléculaire:410.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Help & FAQs
Activité biologique
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Cdk1/cyclin B 2 nM (IC50) |
CDK2/cyclinE 6 nM (IC50) |
CDK4/cyclin D 12 nM (IC50) |
AG-12286 acts as a pan-cyclin-dependent kinase inhibitor, potently inhibiting cdk1/cycB (IC50 = 2 nM), cdk2/cycE (IC50 = 6 nM), and cdk4/cycD (IC50 = 12 nM) while showing >1000X selectivity over PKC[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 223784-75-6
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Masse moléculaire 410.42
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Formule C16H12F2N4O3S2
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SMILES
O=C(C1=C(F)C=CC=C1F)C2=C(N)N=C(NC3=CC=C(S(=O)(N)=O)C=C3)S2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AG-12286 Related Classifications
HY-183854 Related Classifications
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