Apoptosis inducer 43
Apoptosis inducer 43 is an apoptosis inducer. Apoptosis inducer 43 can induce apoptosis, SubG0-G1 cell cycle arrest, secondary necrosis, and upregulate caspase-3, p53, and Bax/Bcl-2 expression in HCT116 cells. Apoptosis inducer 43 can inhibit tumor growth in a solid Ehrlich carcinoma (SEC) mouse model. Apoptosis inducer 43 can be used to study cancers such as colon cancer, leukemia, and non-small cell lung cancer.
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- Formule: C32H27F3N2O4
- Masse moléculaire:560.56
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
[1]|
Caspase 3 |
Bcl-2 |
Bax |
In Vitro
Apoptosis inducer 43 (Compound 5f) (10 μM) shows anticancer activity and demonstrates an average inhibition percentage exceeding 80% and an average GI50 below 5 μM against NCI 60 cells (leukemia, non-small cell lung, colon, central nervous system, melanoma, ovarian, renal prostate, and breast cancer)[1].
Apoptosis inducer 43 (1.79-10 μM, 24 h) induces cell cycle arrest, primarily at the SubG0/G1 phase, induces apoptosis in HCT-116 cells [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-116 cells
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Concentration:10 μM
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Incubation Time:24 h
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Result:Induced changes in cell cycle distribution, leading to cell cycle arrest in the SubG0-G1 phase, with the percentage of cells in the G0/G1 cycle increasing from 7% (control sample) to 44%.
Resulted in reduction of the percentage of cells in the remaining phases, G0-G1, S and G2/M.
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Cell Line:HCT-116 cells
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Concentration:1.79 μM
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Incubation Time:24 h
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Result:Decreased the percentage of live cells and increased the proportion of necrotic cells.
Increased the levels of caspase-3, p53, and Bax proteins, and decreased the level of Bcl-2 protein.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SEC (0.2 mL/mouse) female Swiss albino mice (18-22g) model[1]
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Dosage:10 mg/kg
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Administration:i.p., three times weekly, 14 days
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Result:Demonstrated antitumor effects, resulting in a 72.5% reduction in tumor volume and a 76% reduction in tumor weight.
Showed small foci of tumor cells with distinct mitotic figures were surrounded by large areas of necrosis.
Reduced mitotic cell counts and VEGF expression.
Chemical Information
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Masse moléculaire 560.56
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Formule C32H27F3N2O4
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SMILES
O=C(NC1=CC=CC(C(/C=C/C2=CC=C(C3=CC=CC=C3)C=C2)=O)=C1)C([NH3+])CC4=CC=CC=C4.FC(F)(F)C([O-])=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apoptosis inducer 43 Related Classifications
HY-175332 Related Classifications
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