Apoptotic agent-2
Apoptotic agent-2 (compound 14b) induces apoptosis by down-regulation of Bcl-2 and up-regulation of Bax and caspase-3. Apoptotic agent-2 exhibits anti-proliferative activities and can be used for cancer research.
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- CAS No.: 2482310-18-7
- Formule: C25H16ClN7S
- Masse moléculaire:481.96
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Activité biologique
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Chemical Information
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Activité biologique
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Bax |
Caspase 3 |
Bcl-2 |
Apoptotic agent-2 (compound 14b) (24 hours) has selective anti-proliferative activities against HCT-116, HepG-2, MCF-7 and WI-38 (normal human cells) cells with IC50 values of 1.96, 1.12, 2.38 and 107.5 µM, respectively[1].
Apoptotic agent-2 (compound 14b) (1.12 μM; 24 hours; HepG-2 cells) induces cell apoptosis, which increases the levels of active Caspase-3 and BAX by 10.92 folds and 9.7 folds, respectively, and decreases the level of Bcl-2 by 3.3 folds[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG-2 cells
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Concentration:1.12 μM
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Incubation Time:24 hours
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Result:The percentage of cells in the G2-M phase increased while the percentage of cells in G0-G1 phase and S phase decreased.
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Cell Line:HepG-2 cells
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Concentration:1.12 μM
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Incubation Time:24 hours
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Result:Increased the early apoptosis ratio from 0.69% to 5.17% and increased the late apoptosis ratio from 0.32% to 12.11%.
Chemical Information
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CAS No. 2482310-18-7
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Masse moléculaire 481.96
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Formule C25H16ClN7S
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SMILES
CC1=C(/N=N/C2=CC=C(Cl)C=C2)SC(N/N=C3C4=C(C5=NC6=CC=CC=C6N=C5\3)C=CC=C4)=N1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apoptotic agent-2 Related Classifications
HY-147928 Related Classifications
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