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Cat. No.: HY-149348

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DiPT-4

DiPT-4 is a dual TOP1/PARP1 inhibitor that induces massive DNA double-strand breaks (DSBs), cell cycle arrest, and apoptosis in cancer cells. DiPT-4 has the potential to overcome cancer drug resistance.

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CAS No.: 3052259-89-6
Formule: C₃₂H₂₂FN₅O₄S
Masse moléculaire:591.61

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

DiPT-4 Chemical Structure

CAS No.: 3052259-89-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
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Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Topoisomerase :

Voir tous les produits spécifiques à Isoform PARP :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	4 μM Compound: DiPT-4	Cytotoxicity against human HCT-116 cells incubated for 72 hrs by MTT assay Cytotoxicity against human HCT-116 cells incubated for 72 hrs by MTT assay	[PMID: 37406384]
MIA PaCa-2	IC₅₀	4.5 μM Compound: DiPT-4	Cytotoxicity against human MIA PaCa-2 cells incubated for 72 hrs by MTT assay Cytotoxicity against human MIA PaCa-2 cells incubated for 72 hrs by MTT assay	[PMID: 37406384]
PANC-1	IC₅₀	4 μM Compound: DiPT-4	Cytotoxicity against human PANC-1 cells incubated for 72 hrs by MTT assay Cytotoxicity against human PANC-1 cells incubated for 72 hrs by MTT assay	[PMID: 37406384]

Chemical Information

CAS No. 3052259-89-6
Masse moléculaire 591.61
Formule C₃₂H₂₂FN₅O₄S
SMILES

O=C1N(CC2=NN=C(SCCN3C(C4=CC=CC5=CC=CC(C3=O)=C45)=O)O2)N=C(CC6=CC=C(F)C=C6)C7=C1C=CC=C7
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Guha Majumdar A, et al. Design, synthesis and development of a dual inhibitor of Topoisomerase 1 and poly (ADP-ribose) polymerase 1 for efficient killing of cancer cells. Eur J Med Chem. 2023 Oct 5;258:115598. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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DiPT-4

Voir tous les produits spécifiques à Isoform Topoisomerase

Voir tous les produits spécifiques à Isoform PARP

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

DiPT-4 Related Classifications

HY-149348 Related Classifications