Bace1 - beta-secretase 1 Gene

Also Known as Bace

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29392

About Bace1

Primary_assembly 8: 46,142,116-46,165,876 forward strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 219 orthologues, 8 paralogues and is associated with 22 phenotypes. Biased expression in Brain (RPKM 222.4), Heart (RPKM 151.3) and 9 other tissues.

Summary

Enables peptidase activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to metal ion; and detection of mechanical stimulus involved in sensory perception of pain. Located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and neuronal cell body. Used to study dementia. Biomarker of Alzheimer's disease; sensory peripheral neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE1 (Beta-secretase 1). [provided by Alliance of Genome Resources, Apr 2022]

Bace1 Products (1)

mRNA Protein Name
NM_019204.2 NP_062077.1 beta-secretase 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables peptidase activity IDA
IDA: Inferred from direct assay
10531052 RGD
Biological Process GO Annotation Evidence Références Source
involved in amyloid-beta metabolic process IMP
IMP: Inferred from mutant phenotype
10531052 RGD
involved in cellular response to amyloid-beta IEP
IEP: Inferred from expression pattern
26984601 RGD
involved in cellular response to copper ion IEP
IEP: Inferred from expression pattern
18583042 RGD
involved in cellular response to manganese ion IEP
IEP: Inferred from expression pattern
18583042 RGD
involved in detection of mechanical stimulus involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
28012171 RGD
involved in prepulse inhibition IMP
IMP: Inferred from mutant phenotype
28281673 RGD
involved in response to lead ion IEP
IEP: Inferred from expression pattern
29908845 RGD
Cellular Component GO Annotation Evidence Références Source
located in axon IDA
IDA: Inferred from direct assay
26552445 RGD
located in dendrite IDA
IDA: Inferred from direct assay
26552445 RGD
located in endosome IDA
IDA: Inferred from direct assay
10531052 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
26552445 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
26296617 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bace1 Protein Structure

beta_secretase_like

beta_secretase_like: cd05473 (71 - 436)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 501 a.a.
Protein Preferred Names Protein Names

beta-secretase 1

  • ASP2

  • asp 2

  • aspartyl protease 2

  • beta-site APP cleaving enzyme 1

  • beta-site amyloid precursor protein cleaving enzyme 1

  • memapsin-2

  • membrane-associated aspartic protease 2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (9)
Cat. No. Nom du produit Effect
Pureté Phase
HY-16759 Verubecestat Inhibitor 99.56% Phase 3
HY-100740 Lanabecestat Inhibitor 99.87% Phase 3
HY-109055 Elenbecestat Inhibitor 99.82% Phase 3
HY-109052 Atabecestat Inhibitor 98.97% Phase 3
HY-114245 Se-Methylselenocysteine Inhibitor 99.95% Phase 1
HY-10472 LY2811376 Inhibitor 99.64% Phase 1
HY-13438 AZD3839 free base Inhibitor 99.97% Phase 1
HY-112157 PF-06751979 Inhibitor 99.57% Phase 1
HY-100182 BACE1-IN-1 Inhibitor 98.72% Phase 1

Pre-clinical Phase

Bioactive Molecules (46)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-13240 LY2886721 Inhibitor 99.72% Unkown
HY-N0226A Epiberberine chloride Inhibitor 98.68% Unkown
HY-15908 BCA Inhibitor 99.99% Unkown
HY-N1255 Scoulerine Inhibitor 99.99% Unkown
HY-136742 BACE2-IN-1 Inhibitor 99.4% Unkown
HY-124322 NB-360 Inhibitor 99.08% Unkown
HY-W015515 L-Citronellol Inhibitor 99.92% Unkown
HY-111383 LX2343 Inhibitor 99.80% Unkown
HY-N2215 Aloeresin D Inhibitor 99.51% Unkown
HY-N2284 Sophoflavescenol Inhibitor 98.78% Unkown
HY-100740C (1α,1'S,4β)-Lanabecestat Inhibitor 96.01% Unkown
HY-N0226 Epiberberine Inhibitor 98.46% Unkown
HY-130244 BACE1-IN-5 Inhibitor / Unkown
HY-128774 AM-6494 Inhibitor / Unkown
HY-112444 BACE1-IN-2 Inhibitor / Unkown
HY-128594 BACE1-IN-4 Inhibitor / Unkown
HY-P3426 BACE1-IN-10 Inhibitor / Unkown
HY-181160 JNK3/Wnt/β-catenin modulator-1 Inhibitor / Unkown
HY-N13064 2,2′,4,4′-Tetrahydroxychalcone Inhibitor / Unkown
HY-147851 BACE1-IN-12 Inhibitor / Unkown
HY-N1255A Scoulerine hydrochloride Inhibitor / Unkown
HY-W750970 2-Acetoxyacorenone Inhibitor / Unkown
HY-122080 Memoquin Inhibitor / Unkown
HY-147758 BACE1/2-IN-1 Inhibitor / Unkown
HY-151348 BACE1-IN-11 Inhibitor / Unkown
HY-182786 MAO-B-IN-56 Inhibitor / Unkown
HY-149211 AChE/BChE-IN-12 Inhibitor / Unkown
HY-161359 BACE1-IN-14 Inhibitor / Unkown
HY-144741 BACE1-IN-9 Inhibitor / Unkown
HY-11014 NB-216 Inhibitor / Unkown
HY-P2713 OM99-2 Inhibitor / Unkown
HY-100182A BACE1-IN-1 hydrochloride Inhibitor / Unkown
HY-183796 GFAP/NF-κB/APOE/NLRP3-IN-1 Inhibitor / Unkown
HY-139720 β-Secretase Inhibitor III Inhibitor / Unkown
HY-182429 NB-533 Inhibitor / Unkown
HY-151260 AChE/BACE1/GSK3β-IN-1 Inhibitor / Unkown
HY-114234A TAK-070 Free base Inhibitor / Unkown
HY-164956 TB-9 Inhibitor / Unkown
HY-12938 AMG-8718 Inhibitor / Unkown
HY-114234 TAK-070 hydrochloride hydrate Inhibitor / Unkown
HY-N8912 Ambrosin Inhibitor / Unkown
HY-175661 SRI-22136 Inhibitor / Unkown
HY-N18261 8-Geranyloxy-5-methoxypsoralen Inhibitor / Unkown
HY-170938 AChE-IN-82 Inhibitor / Unkown
HY-126047 (S)-(-)-Anatabine Inhibitor / Unkown
HY-164958 TB-11 Inhibitor 98.71% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bace1 NCBI NCBI:23621