SJY26
SJY26 is a PI3K/HDAC dual-target inhibitor with IC50s of 0.59 nM (PI3Kα and PI3Kδ), 2.02 nM (PI3Kγ), 12.69 nM (PI3Kβ) and 114 nM (HDAC1). SJY26 exhibits potent broad-spectrum anti-proliferative activity, and is particularly sensitive to Jurkat and PC9R cells. SJY26 inhibited the migration of PC9R cells, arrested the cell cycle and induced cell apoptosis. SJY26 reduces AKT phosphorylation, and decreases histone H3 deacetylation (Ac-H3). SJY26 can be used for the studies of non-small cell lung cancer and leukemia.
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- Formule: C35H26F2N6O5S
- Masse moléculaire:680.68
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
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PI3Kα 0.59 nM (IC50) |
PI3Kδ 0.59 nM (IC50) |
PI3Kγ 2.02 nM (IC50) |
PI3Kβ 12.69 nM (IC50) |
HDAC1 114 nM (IC50) |
SJY26 (24 h) exhibits potent inhibitory activity against Jurkat, PC9R, MCF-7 and K562 cells with IC50s of 0.38 μM, 0.59 μM, 1.98 μM and 4.30 μM[1].
SJY26 (1.25-2.5 μM, 0-48 h) effectively inhibits the migration ability of PC9R cells in a concentration-dependent manner[1].
SJY26 (2.5 μM, 24 h) arrests PC9R cells in the G2/M phase, preventing them from entering mitosis and completing proliferation[1].
SJY26 (2.5-5 μM, 48 h) induces cell apoptosis in a concentration-dependent manner in PC9R cells[1].
SJY26 (2.5-5 μM, 24 h) down-regulates the PI3K-AKT signaling pathway while up-regulates the level of histone acetylation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC9R cells
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Concentration:1.25 μM and 2.5 μM
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Incubation Time:0, 24 and 48 h
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Result:Effectively inhibited the migration ability of PC9R cells in a concentration-dependent manner.
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Cell Line:PC9R cells
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Concentration:2.5 μM
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Incubation Time:24 h
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Result:Significantly increased the proportion of cells in the G2/M phase.
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Cell Line:PC9R cells
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Concentration:2.5 μM and 5 μM
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Incubation Time:48 h
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Result:Induced cell apoptosis in a concentration-dependent manner.
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Cell Line:PC9R cells
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Concentration:2.5 μM and 5 μM
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Incubation Time:24 h
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Result:Down-regulated the PI3K-AKT signaling pathway while up-regulated the level of histone acetylation.
Chemical Information
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Masse moléculaire 680.68
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Formule C35H26F2N6O5S
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SMILES
O=C(C1=CC=NC2=CC=C(C3=CC(NS(=O)(C4=CC=C(F)C=C4F)=O)=C(OC)N=C3)C=C12)NC5=CC=C(C(NC6=CC=CC=C6N)=O)C=C5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SJY26 Related Classifications
HY-178485 Related Classifications
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