TM-233
TM-233 is an inhibitor of the JAK/STAT and NF-κB signaling pathways, exhibiting significant antitumor activity. TM-233 reduces the expression of the anti-apoptotic protein Mcl-1 by inhibiting the phosphorylation of JAK2 and STAT3, and regulates its transcription by directly binding to the Mcl-1 gene promoter. Additionally, TM-233 prevents the translocation of NF-κB from the cytoplasm to the nucleus by inhibiting its DNA-binding activity, thereby reducing nuclear NF-κB expression. TM-233 shows potential in overcoming Bortezomib (HY-10227) resistance and can be applied in research related to multiple myeloma.
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- CAS No.: 1103745-28-3
- Formule: C25H20O4
- Masse moléculaire:384.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
|
JAK2 |
Stat-3 |
Mcl-1 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
0.12 μM
Compound: 18
|
Cytotoxicity against human HL60 cells assessed as growth inhibition after 3 days
Cytotoxicity against human HL60 cells assessed as growth inhibition after 3 days
|
[PMID: 25801158] |
| IM-9 | IC50 |
0.23 μM
Compound: 18
|
Cytotoxicity against human IM9 cells assessed as growth inhibition after 3 days
Cytotoxicity against human IM9 cells assessed as growth inhibition after 3 days
|
[PMID: 25801158] |
Chemical Information
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CAS No. 1103745-28-3
-
Masse moléculaire 384.42
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Formule C25H20O4
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SMILES
CC(OC(C1=CC=C(C=C1)OC(C)=O)C2=C3C=CC=CC3=CC4=CC=CC=C24)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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