CDK9-IN-18
CDK9-IN-18 is a potent CDK9 inhibitor. CDK9-IN-18 blocks the phosphorylation function of kinase CDK9. CDK9-IN-18 exhibits both good anticancer activity and low cellular activity. CDK9-IN-18 induces apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 1804127-83-0
- Formula: C27H20N8O
- Molecular Weight:472.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
CDK9-IN-18 (compound 12i) (0-20 μM, 3 hours; NH2 cells) suppress both HIV-1 transcription and the phosphorylation at Serine 2 of the RNAPII CTD in a dose-dependent manner[1].
CDK9-IN-18 (compound 12i) (0-5.0 μM, 24 hours; human tumor cell lines) exerts antiproliferative effect through the induction of apoptosis in HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NH2 cells
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Concentration:0.1, 0.2, 0.5, 1.0 and 2.0 μM
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Incubation Time:3 hours
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Result:P-Ser2 level of RNAPII CTD decreased in a dose-dependent fashion.
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Cell Line:A375 (skin cancer), A549 (lung cancer), HepG2 (liver cancer) and MCF-7 (breast cancer)
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Concentration:2.0 μM
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Incubation Time:24 hours
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Result:Inhibited with IC50 values of 0.10, 0.53, 0.07 and 0.10 μM for A375, A549, HepG2 and MCF-7 cells, respectively.
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Cell Line:A375 (skin cancer), A549 (lung cancer), HepG2 (liver cancer) and MCF-7 (breast cancer)
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Concentration:0.1, 0.2, 0.5, 1.0, 2.0 and 5.0 μM
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Incubation Time:24 hours
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Result:The expression level of the specific apoptosisassociated protein (cleaved PARP) increased in a dose-dependent fashion.
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Cell Line:HepG2 cells
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Concentration:1.0 and 5.0 μM
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Incubation Time:24 hours
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Result:The percentage of cells in late apoptosis was recorded as 24.2% and 36.3% at 1.0 and 5.0 μM concentrations, respectively.
Chemical Information
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CAS No. 1804127-83-0
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Molecular Weight 472.50
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Formula C27H20N8O
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SMILES
O=C(C(N1)=CC2=C1C=CC(NC3=NC=CC(C4=CC=CN=C4)=N3)=C2)N/N=C/C5=CNC6=C5C=CC=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK9-IN-18 Related Classifications
HY-147905 Related Classifications
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