2. Epigenetics TGF-beta/Smad Cell Cycle/DNA Damage
  3. PKC DNA/RNA Synthesis
  4. CGP-53353

CGP-53353  (Synonyms: DAPH-7)

Cat. No.: HY-108600 Purity: 98.87%
COA Handling Instructions

CGP-53353 (DAPH-7) is an potent PKC inhibitor with IC50s of 0.41 μM and 3.8 μM for PKCβII and PKCβI, respectively. CGP-53353 can inhibit glucose-induced cell proliferation and DNA synthesis in AoSMC and A10 cells. CGP-53353 can be used for researching atherosclerosis of diabetic patients.

For research use only. We do not sell to patients.

CGP-53353 Chemical Structure

CGP-53353 Chemical Structure

CAS No. : 145915-60-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 176 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 176 In-stock
Solid
5 mg USD 160 In-stock
10 mg USD 250 In-stock
25 mg USD 550 In-stock
50 mg USD 950 In-stock
100 mg USD 1550 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

CGP-53353 Related Antibodies

Top Publications Citing Use of Products

View All PKC Isoform Specific Products:

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

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Description

CGP-53353 (DAPH-7) is an potent PKC inhibitor with IC50s of 0.41 μM and 3.8 μM for PKCβII and PKCβI, respectively. CGP-53353 can inhibit glucose-induced cell proliferation and DNA synthesis in AoSMC and A10 cells. CGP-53353 can be used for researching atherosclerosis of diabetic patients[1].

IC50 & Target[1]

PKCβII

0.41 mM (IC50)

PKCβI

3.8 mM (IC50)

In Vitro

CGP-53353 (DAPH-7) (1 μM; 48-96 hours) inhibits glucose-induced cell proliferation in A10 cells[1].
CGP-53353 (1 μM ; 0-48 hours) inhibits the glucose-induced increase and acceleration of DNA synthesis in A10, also blocks the glucose-induced increase of S-phase cell percentage[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CGP-53353 Related Antibodies

Cell Proliferation Assay

Cell Line: A10 (cell proliferation induced by glucose)[1]
Concentration: 1 μM
Incubation Time: 48-96 hours
Result: Inhibited glucose-induced cell proliferation, although A10 cell proliferation was stimulated by increasing glucose concentrations.
Molecular Weight

365.33

Appearance

Solid

Formula

C20H13F2N3O2
CAS No.
SMILES

O=C1NC(C2=C1C=C(NC3=CC=C(F)C=C3)C(NC4=CC=C(F)C=C4)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (136.86 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7373 mL 13.6863 mL 27.3725 mL
5 mM 0.5475 mL 2.7373 mL 5.4745 mL
10 mM 0.2737 mL 1.3686 mL 2.7373 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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CGP-53353 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

CGP-53353145915-60-2DAPH-7CGP53353CGP 53353DAPH7DAPH 7PKCDNA/RNA SynthesisProtein kinase CVSMCCell proliferationGlucoseDiabetesInhibitorinhibitorinhibit

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