1. Epigenetics
    TGF-beta/Smad
    Cell Cycle/DNA Damage
  2. PKC
    DNA/RNA Synthesis
  3. CGP-53353

CGP-53353 (Synonyms: DAPH-7)

Cat. No.: HY-108600
Handling Instructions

CGP-53353 (DAPH-7) is an potent PKC inhibitor with IC50s of 0.41 mM and 3.8 mM for PKCβII and PKCβI, respectively. CGP-53353 can inhibit glucose-induced cell proliferation and DNA synthesis in AoSMC and A10 cells. CGP-53353 can be used for researching atherosclerosis of diabetic patients.

For research use only. We do not sell to patients.

CGP-53353 Chemical Structure

CGP-53353 Chemical Structure

CAS No. : 145915-60-2

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Description

CGP-53353 (DAPH-7) is an potent PKC inhibitor with IC50s of 0.41 mM and 3.8 mM for PKCβII and PKCβI, respectively. CGP-53353 can inhibit glucose-induced cell proliferation and DNA synthesis in AoSMC and A10 cells. CGP-53353 can be used for researching atherosclerosis of diabetic patients[1].

IC50 & Target[1]

PKCβII

0.41 mM (IC50)

PKCβI

3.8 mM (IC50)

In Vitro

CGP-53353 (DAPH-7) (1 μM; 48-96 hours) inhibits glucose-induced cell proliferation in A10 cells[1].
CGP-53353 (1 μM ; 0-48 hours) inhibits the glucose-induced increase and acceleration of DNA synthesis in A10, also blocks the glucose-induced increase of S-phase cell percentage[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line: A10 (cell proliferation induced by glucose)[1]
Concentration: 1 μM
Incubation Time: 48-96 hours
Result: Inhibited glucose-induced cell proliferation, although A10 cell proliferation was stimulated by increasing glucose concentrations.
Molecular Weight

365.33

Formula

C20H13F2N3O2

CAS No.
SMILES

O=C1NC(C2=C1C=C(NC3=CC=C(F)C=C3)C(NC4=CC=C(F)C=C4)=C2)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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CGP-53353
Cat. No.:
HY-108600
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