CGP-53353
Based on 1 Customer Validation
CGP-53353 (DAPH-7) is an potent PKC inhibitor with IC50s of 0.41 μM and 3.8 μM for PKCβII and PKCβI, respectively. CGP-53353 can inhibit glucose-induced cell proliferation and DNA synthesis in AoSMC and A10 cells. CGP-53353 can be used for researching atherosclerosis of diabetic patients.
For research use only. We do not sell to patients.
- Purity: 98.87%
- CAS No.: 145915-60-2
- Formula: C20H13F2N3O2
- Molecular Weight:365.33
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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PKCβII 0.41 mM (IC50) |
PKCβI 3.8 mM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
2.2 μM
Compound: 4
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Inhibition of EGF-dependent autophosphorylation of EGF-R in human A431 cells
Inhibition of EGF-dependent autophosphorylation of EGF-R in human A431 cells
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[PMID: 8151612] |
CGP-53353 (DAPH-7) (1 μM; 48-96 hours) inhibits glucose-induced cell proliferation in A10 cells[1]. CGP-53353 (1 μM ; 0-48 hours) inhibits the glucose-induced increase and acceleration of DNA synthesis in A10, also blocks the glucose-induced increase of S-phase cell percentage[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A10 (cell proliferation induced by glucose)[1]
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Concentration:1 μM
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Incubation Time:48-96 hours
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Result:Inhibited glucose-induced cell proliferation, although A10 cell proliferation was stimulated by increasing glucose concentrations.
Chemical Information
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CAS No. 145915-60-2
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Appearance Solid
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Molecular Weight 365.33
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Formula C20H13F2N3O2
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Color Light yellow to yellow
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SMILES
O=C1NC(C2=C1C=C(NC3=CC=C(F)C=C3)C(NC4=CC=C(F)C=C4)=C2)=O
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Synonyms
DAPH-7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 50 mg/mL (136.86 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7373 mL | 13.6863 mL | 27.3725 mL | 68.4313 mL |
| 5 mM | 0.5475 mL | 2.7373 mL | 5.4745 mL | 13.6863 mL | |
| 10 mM | 0.2737 mL | 1.3686 mL | 2.7373 mL | 6.8431 mL | |
| 15 mM | 0.1825 mL | 0.9124 mL | 1.8248 mL | 4.5621 mL | |
| 20 mM | 0.1369 mL | 0.6843 mL | 1.3686 mL | 3.4216 mL | |
| 25 mM | 0.1095 mL | 0.5475 mL | 1.0949 mL | 2.7373 mL | |
| 30 mM | 0.0912 mL | 0.4562 mL | 0.9124 mL | 2.2810 mL | |
| 40 mM | 0.0684 mL | 0.3422 mL | 0.6843 mL | 1.7108 mL | |
| 50 mM | 0.0547 mL | 0.2737 mL | 0.5475 mL | 1.3686 mL | |
| 60 mM | 0.0456 mL | 0.2281 mL | 0.4562 mL | 1.1405 mL | |
| 80 mM | 0.0342 mL | 0.1711 mL | 0.3422 mL | 0.8554 mL | |
| 100 mM | 0.0274 mL | 0.1369 mL | 0.2737 mL | 0.6843 mL |
CGP-53353 Related Classifications
HY-108600 Related Classifications
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