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Go 6983

(Synonyms: Gö 6983; Goe 6983)
85 Cited Publications
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Based on 85 publication(s) in Google Scholar

Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.

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  • Reinheit: 99.23%
  • CAS. Nr.: 133053-19-7
  • Formel: C26H26N4O3
  • Molecular Weight:442.51
  • Speicherung:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Go 6983 Chemical Structure
    Go 6983 Chemical Structure
  • Experimental Validation Results for Go 6983
  • Experimental Validation Results for Go 6983
  • Experimental Validation Results for Go 6983
  • Experimental Validation Results for Go 6983
  • Experimental Validation Results for Go 6983
  • Experimental Validation Results for Go 6983
  • Experimental Validation Results for Go 6983
  • Experimental Validation Results for Go 6983
CAS. Nr.: 133053-19-7
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  • Go 6983 Chemical Structure
    Go 6983 Chemical Structure
    1/16
  • 1/16

    Go 6983 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 7;16(1):1429. [Abstract]

    Customer Validation
     g-j. The effects of JNK (JNK-IN-8) (25 nM) and PKC (Go 6983) (100 nM) inhibition on the expression of Cxcl10 and Ccl4 in MC38 and Panc02 cells.

  • 1/16

    Go 6983 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 7;16(1):1429. [Abstract]

    Customer Validation
     FACS analysis of CD8+ T-cell proliferation (CFSE low) in cultured with conditioned media derived from MC38 cells treated with WNT11 and inhibitors of CAMKII (CAMKII-IN-1)(100 nM), JNK (JNK-IN-8)(25 nM) and PKC (Go 6983)(100 nM) as indicated.

  • 1/16

    Go 6983 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Feb 7;9(2):165. [Abstract]

    Customer Validation
     Western blot analysis of MCF-7 cells treated with Tan IIA at the specified concentrations for the expression of cytosolic PKC isoforms. The compound Go 6983 (GO, 20 μM) is included as a positive control.

  • 1/16

    Go 6983 purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 Sep 3;503(1):62-70. [Abstract]

    Customer Validation
     BMMs are incubated in serum-free medium and pretreated with or without Go6983 (0, 2.5 μM) for 4 h. Next, the BMMs are stimulated by RANKL (50 ng/mL) for the indicated times (0, 15, 30, 60 min). Additionally, the BMM lysates are analyzed by western blotting.

  • 1/16

    Go 6983 purchased from MedChemExpress. Usage Cited in: J Appl Toxicol. 2016 Nov;36(11):1409-17.  [Abstract]

    Customer Validation
     Protein levels of GLT-1 analyzed by Western blotting in C6 cells then treated with TCDD for 12 h. Cells are pre-treated with Ca2+-signaling blocker BAY-a-1040 (25 nM) for 30min before TCDD stimulation. The PKC inhibitor staurosporine (10 nM) and Go 6983 (1 μM) is applied 2 h before adding TCDD.

  • 1/16

    Go 6983 purchased from MedChemExpress. Usage Cited in: J Appl Toxicol. 2016 Nov;36(11):1409-17.  [Abstract]

    Customer Validation
     Quantitative analysis of the intensity of GLT-1 expression relative to GAPDH in the indicated groups. Cells are pre-treated with Ca2+-signaling blocker BAY-a-1040 (25 nM) for 30min before TCDD stimulation. The PKC inhibitor staurosporine (10 nM) and Go 6983 (1 μM) is applied 2 h before adding TCDD.

  • 1/16

    Go 6983 purchased from MedChemExpress. Usage Cited in: J Appl Toxicol. 2016 Nov;36(11):1409-17.  [Abstract]

    Customer Validation
     Immunofluorescence staining of PKC after pre-treatment with the Ca2+-signaling blocker and the PKC inhibitor. PKC is enriched in cytoplasmor perinucleus in untreated C6 cells (a-c), Go 6983-treated cells (g-i) or BAY-a-1040-treated cells (m-o). TCDD induces PKC translocation to the membrane in C6 glioma cells (d-f ).

  • 1/16

    Go 6983 purchased from MedChemExpress. Usage Cited in: Vet Microbiol. 2016 Aug 30:192:26-33. [Abstract]

    Customer Validation
     Effect of PKC inhibitor on NF-kB DNA binding activity and NFAT inhibitor on NFATc1 DNA binding activity. Lane N is negative control; lane 1 is control group; lane 2 is S. uberis group; lane 3 is pre-treated with 2 μM Go 6983; lane 4 is pre-treated with 5 μM Go 6983; lane 5 is pre-treated with 10 μM Go 6983.

  • Go 6983