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Oridonin

(Synonyms: NSC-250682; Isodonol)
27 Cited Publications
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Based on 27 publication(s) in Google Scholar

Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.

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  • Reinheit: 99.89%
  • CAS. Nr.: 28957-04-2
  • Formel: C20H28O6
  • Molecular Weight:364.43
  • Speicherung:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Oridonin Chemical Structure
    Oridonin Chemical Structure
  • Experimental Validation Results for Oridonin
  • Experimental Validation Results for Oridonin
  • Experimental Validation Results for Oridonin
  • Experimental Validation Results for Oridonin
  • Experimental Validation Results for Oridonin
CAS. Nr.: 28957-04-2
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ELISAIn Vivo Efficacy StudyBio/Physico-chemical AssayWB
  • ELISA
  • WB
  • In Vivo Efficacy Study
  • WB
  • Bio/Physico-chemical Assay

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  • Oridonin Chemical Structure
    Oridonin Chemical Structure
    1/16
  • 1/16

    Oridonin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 May 27;16(1):4887. [Abstract]

    Customer Validation
     Oridonin (0.5-2.5 µM; 11 h). NLRP3-KO iBMDMs were stimulated with LPS and Dox after a 30-min pre-incubation with inhibitors or DMSO, except for Ctrl, where only LPS was added. Measurements of IL-1β were normalized to “LPS/Dox”- treated WTR258W.

  • 1/16

    Oridonin purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2025 May 28;82(1):218. [Abstract]

    Customer Validation
     CD3/CD28 mAbs-stimulated lymphocytes were treated with AKT inhibitor Oridonin (10 μM) or not. Western blot showing the expression of indicated molecules at 3 h.

  • 1/16

    Oridonin purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2023 Apr;44(4):726-740. [Abstract]

    Customer Validation
     Oridonin (Ori; 5-20 mg/kg; ip). The infarct volume was determined by conducting TTC staining at 1 d after reperfusion. Representative TTC-stained brain slices of different groups are shown.

  • 1/16

    Oridonin purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2023 Apr;44(4):726-740. [Abstract]

    Customer Validation
     Oridonin (Ori; 5-20 mg/kg; ip). The expression levels of Bax, Bcl-2, mitochondrial Cyto-C, cytoplasmic Cyto-C, caspase-3 and cleaved caspase-3 were measured by Western blot analysis in the ipsilateral brain region at 1 d after reperfusion.

  • 1/16

    Oridonin purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2021 Dec 31;79(1):27. [Abstract]

    Customer Validation
     Time-dependent PHGDH inhibition. Samples of 200 nM PHGDH were pre-incubated with 1 μM Oridonin for the indicated times, and then PHGDH activity was monitored for 5 h. The time line is shown above. Black arrow indicates the start of the reaction. The data are normalized to the 5 h reading of the ‘0 min’ pre-incubated enzyme.

  • Oridonin