Andrographidine E
Andrographidine E is a COX-2 (IC50 = 19 μM) and HDAC inhibitor, with high affinity for HDAC1 and HDAC3. Andrographidine E can specifically bind to macrophages and has potential immunotargeting properties. Andrographidine E can be used for studying inflammation.
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- CAS. Nr.: 113963-41-0
- Formel: C24H26O11
- Molecular Weight:490.46
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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HDAC1 |
HDAC3 |
COX-2 19 μM (IC50) |
Chemical Information
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CAS. Nr. 113963-41-0
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Molecular Weight 490.46
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Formel C24H26O11
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SMILES
COC1=C2C(C(C=C(C3=C(C=CC=C3)OC)O2)=O)=C(C=C1OC)O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Das D, et al. Exploring the potential of Andrographis paniculata for developing novel HDAC inhibitors: an in silico approach. J Biomol Struct Dyn. 2025 Jan;43(1):359-371. [Content Brief]
[2]. Wang Y, et al. Screening and Identification for Immunological Active Components from Andrographis Herba Using Macrophage Biospecific Extraction Coupled with UPLC/Q-TOF-MS. Molecules. 2018 Apr 30;23(5):1047. [Content Brief]
[3]. Jiao J, et al. Screening cyclooxygenase-2 inhibitors from Andrographis paniculata to treat inflammation based on bio-affinity ultrafiltration coupled with UPLC-Q-TOF-MS. Fitoterapia. 2019 Sep;137:104259. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Andrographidine E Related Classifications
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