Rho - rhodopsin Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24717

Summary

Enables retinal binding activity and spectrin binding activity. Involved in red, far-red light phototransduction and rhodopsin mediated signaling pathway. Located in photoreceptor outer segment membrane and rough endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital stationary night blindness autosomal dominant 1; fundus albipunctatus; night blindness; retinitis pigmentosa; and retinitis pigmentosa 4. Orthologous to human RHO (rhodopsin). [provided by Alliance of Genome Resources, Apr 2022]

Rho Products (1)

mRNA Protein Name
NM_033441.1 NP_254276.1 rhodopsin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables retinal binding IDA
IDA: Inferred from direct assay
2525480 RGD
enables spectrin binding IDA
IDA: Inferred from direct assay
23704327 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in G protein-coupled opsin signaling pathway IDA
IDA: Inferred from direct assay
8814134 RGD
involved in red, far-red light phototransduction IDA
IDA: Inferred from direct assay
2525480 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in photoreceptor outer segment IDA
IDA: Inferred from direct assay
8814134 RGD
located in photoreceptor outer segment membrane IDA
IDA: Inferred from direct assay
2209754 RGD
located in rough endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
2525480 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rhodopsin

  • Rhodopsin (retinitis pigmentosa 4, autosomal dominant)

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (8)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-10583 Y-27632 dihydrochloride Inhibitor 99.98% Unkown
HY-10583R Y-27632 dihydrochloride (Standard) Inhibitor 99.99% Unkown
HY-12798 Netarsudil Inhibitor 99.94% Unkown
HY-12798B Netarsudil hydrochloride Inhibitor 99.90% Unkown
HY-B0515 Ibandronate Sodium Monohydrate Inducer 99.89% Unkown
HY-12798A Netarsudil dimesylate 99.90% Unkown
HY-19518 Latanoprostene bunod Control 99.75% Unkown
HY-B0515B Ibandronate Sodium Inducer 99.89% Unkown

Clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-109191 Sovesudil Inhibitor 99.91% Phase 3
HY-109191A Sovesudil hydrochloride Inhibitor 99.45% Phase 3
HY-113225B Guanosine triphosphate tritris Inducer / Phase 3
HY-148808 Zelasudil Inhibitor 99.48% Phase 2
HY-I0400 N-Acetylneuraminic acid 99.95% Phase 1

Pre-clinical Phase

Bioactive Molecules (79)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-15392 Chroman 1 Inhibitor 98.97% Unkown
HY-12755 ML141 99.96% Unkown
HY-12646 Rhosin hydrochloride 99.94% Unkown
HY-10583G Y-27632 dihydrochloride (GMP) Inhibitor / Unkown
HY-16563 Narciclasine Activator 99.88% Unkown
HY-17543 ML-323 Inhibitor 99.51% Unkown
HY-12646A Rhosin 98.74% Unkown
HY-13991 CCG-1423 99.88% Unkown
HY-108361 CCG-203971 Inhibitor 99.89% Unkown
HY-104064 1A-116 99.72% Unkown
HY-12649 Y16 Inhibitor 98.12% Unkown
HY-115376 Z62954982 Inhibitor 99.38% Unkown
HY-N6012 (-)-Alkannin Inducer 99.88% Unkown
HY-111458 GSK2643943A Inhibitor 98.79% Unkown
HY-121750 CCG-222740 Inhibitor 99.53% Unkown
HY-134817 USP7-IN-8 Inhibitor 99.04% Unkown
HY-N2438 Methylophiopogonanone B 99.84% Unkown
HY-108518 SB-772077B dihydrochloride Inhibitor 99.33% Unkown
HY-15392A Chroman 1 dihydrochloride Inhibitor 98.13% Unkown
HY-18990 GSK180736A Inhibitor 98.81% Unkown
HY-32951 2-Fluoropyridine-4-boronic acid 99.78% Unkown
HY-112362 3-(4-Pyridyl)indole Inhibitor 99.94% Unkown
HY-N0430A Coptisine Sulfate 99.37% Unkown
HY-111432 CCG-232601 Inhibitor 99.00% Unkown
HY-139170 CAY10746 Inhibitor 98.61% Unkown
HY-117149 MLS000532223 Inhibitor 98.45% Unkown
HY-N0600 Ginsenoside F3 99.84% Unkown
HY-150640 Rho-Kinase-IN-2 Inhibitor 98.80% Unkown
HY-W050122 S-(+)-GABOB 95.0% Unkown
HY-100270 Rho-Kinase-IN-1 Inhibitor 99.91% Unkown
HY-100062 2,4-Dibromo-5-nitropyridine / Unkown
HY-122011 PF-4950834 Inhibitor 99.60% Unkown
HY-126432 NRL-1049 dihydrochloride Inhibitor 99.20% Unkown
HY-15720B Glycyl H-1152 hydrochloride Inhibitor 99.9% Unkown
HY-126913 Rhodblock 6 Inhibitor 98.94% Unkown
HY-152095 PPI-GIT1/β-Pix PPI-IN-1 Inhibitor 99.01% Unkown
HY-N0430 Coptisine / Unkown
HY-P2325 Exoenzyme C3, clostridium botulinum Inhibitor / Unkown
HY-118151 Rho-Kinase-IN-3 Inhibitor 99.74% Unkown
HY-103045A CMPD101 hydrochloride Inhibitor / Unkown
HY-107614G 1-Oleoyl lysophosphatidic acid sodium (GMP) Activator / Unkown
HY-118046 GSK2163632A Inhibitor / Unkown
HY-118837 WF-536 Inhibitor / Unkown
HY-120429 SKLB-163 Inducer / Unkown
HY-123345 CRT 0105446 Inhibitor / Unkown
HY-129907 2-AEMP / Unkown
HY-130011 CCG-232964 Inhibitor / Unkown
HY-132184S 5,6-Epoxyeicosatrienoic acid-d11 / Unkown
HY-134913 Rhodblock 1a Inhibitor / Unkown
HY-137638 Sp-5,6-DCl-cBIMPS Activator / Unkown
HY-137638A Sp-5,6-DCl-cBIMPS sodium Activator / Unkown
HY-138147 DCP-Rho1 / Unkown
HY-13991A (S)-CCG-1423 / Unkown
HY-145294 ROCK2-IN-5 Inhibitor / Unkown
HY-171909 Glycerophosphoinositol 4-phosphate / Unkown
HY-171909A Glycerophosphoinositol 4-phosphate disodium / Unkown
HY-172917 Rho GTPase inhibitor 1 Inhibitor / Unkown
HY-173222 P-gp inhibitor 28 Inhibitor / Unkown
HY-180371 NF-115 Inducer / Unkown
HY-182613 NSC-2888 / Unkown
HY-185667 ROCK2-IN-15 Inhibitor / Unkown
HY-D3474 ATTO Rho 101 NHS ester / Unkown
HY-D3475 ATTO Rho 11 NHS ester / Unkown
HY-N10341 Centaureidin Activator / Unkown
HY-P11847 AT1R-agonist-1 / Unkown
HY-P5158 Conopeptide rho-TIA Inhibitor / Unkown
HY-P5467 S6(229-239), Amide, biotinalyted Substrate / Unkown
HY-RS11944 RHO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11951 RHOD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W047432 5-Nitro-1H-indazole-3-carbonitrile Inhibitor / Unkown
HY-W110138 Chloroxoquinoline / Unkown
HY-123939 JAK1/3-IN-1 Inhibitor / Unkown
HY-130448 8-iso Prostaglandin F1β / Unkown
HY-158652 (R)-CCG-1423 Inhibitor / Unkown
HY-P10393 ERα17p Inducer / Unkown
HY-P10636 Nictide / Unkown
HY-RS17157 Rho Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22304 Rhod Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23607 Rho Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rho NCBI NCBI:6010
Canis familiaris Rho NCBI NCBI:493763
Mus musculus Rho NCBI NCBI:212541