TBK1 - TANK binding kinase 1 Gene

Also Known as NAK; T2K; IIAE8; FTDALS4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29110

About TBK1

Cytogenetic location: 12q14.2 Genomic coordinates (GRCh38): 12:64,452,120-64,502,114 (from NCBI)

This gene has 71 transcripts (splice variants), 201 orthologues, 3 paralogues and is associated with 5 phenotypes. Ubiquitous expression in testis (RPKM 15.8), bone marrow (RPKM 10.3) and 25 other tissues.

Summary

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for Antiviral innate immunity response. [provided by RefSeq, Sep 2021]

TBK1 Products (4)

mRNA	Protein	Name
XM_005268810.2	XP_005268867.1	serine/threonine-protein kinase TBK1 isoform X1
XR_007063071.1
NM_013254.4	NP_037386.1	serine/threonine-protein kinase TBK1
XM_005268809.2	XP_005268866.1	serine/threonine-protein kinase TBK1 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	14530355	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14743216	GOA
enables protein serine/threonine kinase activity	EXP EXP: Inferred from Experiment	27035970	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	14703513	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	25636800	GOA
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	14703513	GOA
involved in cytoplasmic pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	29441066	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	25636800	GOA
involved in negative regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	31530866	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	25636800	GOA
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	25636800	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	29150432	GOA
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	28871090	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IEP IEP: Inferred from expression pattern	12761501	GOA
involved in positive regulation of interferon-alpha production	IDA IDA: Inferred from direct assay	16127453	GOA
involved in positive regulation of interferon-beta production	IDA IDA: Inferred from direct assay	16127453	GOA
involved in positive regulation of macroautophagy	IDA IDA: Inferred from direct assay	27103069	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16127453	GOA
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	14703513	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	27103069	GOA
involved in regulation of type I interferon production	IDA IDA: Inferred from direct assay	25636800	GOA
involved in toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	28747347	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	14703513	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21813773	GOA
is active in cytosol	IDA IDA: Inferred from direct assay	21813773	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TBK1 Protein Structure

Pkinase

0
200
400
600
729 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase TBK1	NF-kB-activating kinase NF-kappa-B-activating kinase

TBK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	TBK1	Q9UHD2	TTC4	Homo sapiens	O95801	Anti Bait CoIP	29251827
Intra	TBK1	Q9UHD2	TTC4	Homo sapiens	O95801	Confocal	29251827
Intra	TBK1	Q9UHD2	MIB1	Homo sapiens	Q86YT6	Anti Tag CoIP	21903422
Cross	TBK1	Q9UHD2	vme1_sars2	SARS-CoV-2	P0DTC5	Anti Bait CoIP	33372174
Cross	TBK1	Q9UHD2	P0DTD1-PRO_0000449630	SARS-CoV-2	P0DTD1-PRO_0000449630	Anti Tag CoIP	33707416
Cross	TBK1	Q9UHD2	M	Human SARS coronavirus	P59596	Anti Tag CoIP	24509444
Intra	TBK1	Q9UHD2	MTPAP	Homo sapiens	Q9NVV4	Anti Tag CoIP	21903422
Intra	TBK1	Q9UHD2	IRF3	Homo sapiens	Q14653	Protein Kinase Assay	19153231
Intra	TBK1	Q9UHD2	IRF3	Homo sapiens	Q14653	IF	17599067
Intra	TBK1	Q9UHD2	IRF3	Homo sapiens	Q14653	Pull Down	17599067
Intra	TBK1	Q9UHD2	IRF3	Homo sapiens	Q14653	Anti Tag CoIP	15841462
Intra	TBK1	Q9UHD2	IRF3	Homo sapiens	Q14653	Anti Tag CoIP	21903422
Intra	TBK1	Q9UHD2	IRF3	Homo sapiens	Q14653	Anti Tag CoIP	25803835
Intra	TBK1	Q9UHD2	STING1	Homo sapiens	Q86WV6	Anti Tag CoIP	19416887
Intra	TBK1	Q9UHD2	IKBKE	Homo sapiens	Q14164	Pull Down	17599067
Intra	TBK1	Q9UHD2	IKBKE	Homo sapiens	Q14164	Anti Tag CoIP	21903422
Intra	TBK1	Q9UHD2	IKBKE	Homo sapiens	Q14164	Anti Bait CoIP	29251827
Intra	TBK1	Q9UHD2	TRAF2	Homo sapiens	Q12933	Pull Down	32707033
Intra	TBK1	Q9UHD2	TRAF2	Homo sapiens	Q12933	Anti Tag CoIP	21903422
Intra	TBK1	Q9UHD2	TANK	Homo sapiens	Q92844	Pull Down	32707033
Intra	TBK1	Q9UHD2	TANK	Homo sapiens	Q92844	Anti Bait CoIP	29251827
Intra	TBK1	Q9UHD2	TANK	Homo sapiens	Q92844	Anti Tag CoIP	21903422
Intra	TBK1	Q9UHD2	TANK	Homo sapiens	Q92844	Anti Tag CoIP	17568778
Intra	TBK1	Q9UHD2	TANK	Homo sapiens	Q92844	TAP	14743216
Intra	TBK1	Q9UHD2	TRAF3	Homo sapiens	Q13114	Anti Bait CoIP	33372174
Intra	TBK1	Q9UHD2	TXLNA	Homo sapiens	P40222	Anti Tag CoIP	21903422
Intra	TBK1	Q9UHD2	TXLNA	Homo sapiens	P40222	Pull Down	32707033
Intra	TBK1	Q9UHD2	TBKBP1	Homo sapiens	A7MCY6	Anti Tag CoIP	17568778
Intra	TBK1	Q9UHD2	TBKBP1	Homo sapiens	A7MCY6	Anti Tag CoIP	21903422
Intra	TBK1	Q9UHD2	TBKBP1	Homo sapiens	A7MCY6	Pull Down	17568778
Intra	TBK1	Q9UHD2	TBKBP1	Homo sapiens	A7MCY6	Pull Down	32707033
Intra	TBK1	Q9UHD2	AZI2	Homo sapiens	Q9H6S1	Anti Bait CoIP	29251827
Intra	TBK1	Q9UHD2	AZI2	Homo sapiens	Q9H6S1	Pull Down	32707033
Intra	TBK1	Q9UHD2	AZI2	Homo sapiens	Q9H6S1	Anti Tag CoIP	21903422
Intra	TBK1	Q9UHD2	TICAM1	Homo sapiens	Q8IUC6	Anti Tag CoIP	15841462
Intra	TBK1	Q9UHD2	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	21903422
Intra	TBK1	Q9UHD2	CDC42BPG	Homo sapiens	Q6DT37	Anti Tag CoIP	21903422
Intra	TBK1	Q9UHD2	CDC42BPG	Homo sapiens	Q6DT37	Pull Down	32707033
Intra	TBK1	Q9UHD2	STX11	Homo sapiens	O75558	Y2H	21988832
Intra	TBK1	Q9UHD2	ATG9A	Homo sapiens	Q7Z3C6	Anti Tag CoIP	21903422
Intra	TBK1	Q9UHD2	CALCOCO2	Homo sapiens	Q13137	Anti Tag CoIP	21903422
Intra	TBK1	Q9UHD2	CALCOCO2	Homo sapiens	Q13137	Pull Down	32707033
Intra	TBK1	Q9UHD2	CALCOCO2	Homo sapiens	Q13137	Anti Bait CoIP	21903422
Intra	TBK1	Q9UHD2	OPTN	Homo sapiens	Q96CV9	Pull Down	32707033
Intra	TBK1	Q9UHD2	OPTN	Homo sapiens	Q96CV9	Anti Tag CoIP	21903422
Intra	TBK1	Q9UHD2	OPTN	Homo sapiens	Q96CV9	Y2H Fragment Pooling	23414517
Intra	TBK1	Q9UHD2	OPTN	Homo sapiens	Q96CV9	Pull Down	18307994
Intra	TBK1	Q9UHD2	OPTN	Homo sapiens	Q96CV9	Anti Tag CoIP	18307994
Cross	TBK1	Q9UHD2	Ddx3x	Mus musculus	Q62167	Peptide Array	18583960
Intra	TBK1	Q9UHD2	IKBKG	Homo sapiens	Q9Y6K9	TAP	14743216
Cross	TBK1	Q9UHD2	i6w9f2_9viru	Phlebovirus JS2010-014	I6W9F2	Confocal	24335286
Intra	TBK1	Q9UHD2	IRF7	Homo sapiens	Q92985	Pull Down	17599067
Intra	TBK1	Q9UHD2	MAVS	Homo sapiens	Q7Z434	Anti Bait CoIP	24643253
Intra	TBK1	Q9UHD2	MAVS	Homo sapiens	Q7Z434	Anti Tag CoIP	21903422
Intra	TBK1	Q9UHD2	MAVS	Homo sapiens	Q7Z434	Anti Bait CoIP	33372174
Cross	TBK1	Q9UHD2	P27958-PRO_0000037573	Hepatitis C virus	P27958-PRO_0000037573	Anti Tag CoIP	15841462
Cross	TBK1	Q9UHD2	VP35	Zaire ebolavirus	Q05127	Anti Bait CoIP	19153231
Cross	TBK1	Q9UHD2	VP35	Zaire ebolavirus	Q05127	Protein Kinase Assay	19153231
Cross	TBK1	Q9UHD2	P27958-PRO_0000037572	Hepatitis C virus	P27958-PRO_0000037572	Anti Tag CoIP	23096996
Cross	TBK1	Q9UHD2	NSs	Dabie bandavirus	W5VXH5	Confocal	24706939
Cross	TBK1	Q9UHD2	NSs	Dabie bandavirus	W5VXH5	Pull Down	24706939

Cross: Cross-species interaction Intra: Intraspecies interaction

TBK1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80519	TBK1 Antibody (YA662)	WB	Human, Mouse, Rat
HY-P80910	TBK1 Antibody (YA040)	WB	Human, Mouse, Rat, Hamster
HY-P80910A	TBK1 Antibody (YA040)(PBS only)	WB	Human, Mouse, Rat, Hamster
HY-P86381	TBK1 Antibody (YA6073)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86674	TBK1 Antibody (YA6366)	WB, IHC-P, IHC-F, IF-Tissue	Human, Rat, Mouse

Related Diseases

Diseases	Alias
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Glaucoma, Primary Open Angle	Glaucoma 1, Open Angle, E Primary Open Angle Glaucoma POAG Adult-Onset Primary Open Angle Glaucoma Chronic Simple Glaucoma GLC1E Primary Open Angle Glaucoma 1e Glaucoma, Open Angle, Primary
Middle East Respiratory Syndrome	Mers Mers - [Middle East Respiratory Syndrome]
Viral Infectious Disease	Arbovirus Infections Viral Disease Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Alzheimer Disease 7	Ad7 Alzheimer'S Disease 7 Alzheimer Disease, Familial, 7 Alzheimer Disease-7 Alzheimer Disease, Familial 7
Glaucoma, Normal Tension	Low Tension Glaucoma Glaucoma, Normal Tension, Susceptibility To Normal Tension Glaucoma Ntg Glaucoma, Normal Pressure NPG Glaucoma, Normal Pressure, Susceptibility To Poag/Npg - [Normal Pressure Primary Open-Angle Glaucoma]
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Paget'S Disease Of Bone	Osteitis Deformans Paget Disease Of Bone Osseous Paget'S Disease Paget Disease Of Bone, Familial Bone Paget Disease Familial Paget'S Disease Of Bone Paget'S Bone Disease Familial Paget Disease Of Bone Paget Disease, Bone Pdb Pagets Bone Disease
Chilblain Lupus 1	Chilblain Lupus CHBL1 Chilblain Lupus Erythematosus Chle Hutchinson Lupus Chilblain Lupus, Type 1
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Sting-Associated Vasculopathy With Onset In Infancy	Savi Sting-Associated Vasculopathy, Infantile Onset Sting-Associated Vasculopathy, Infantile-Onset
Keratitis, Hereditary	Keratitis Autosomal Dominant Keratitis Hereditary Keratitis Dominantly Inherited Keratitis Keratitis Hereditary KERH
Herpes Simplex Encephalitis	Hse Hsv Encephalitis Hsve Herpes Simplex Meningo-Encephalitis Herpes Simplex Neuroinvasion Herpes Simplex Virus Encephalitis Herpetic Encephalitis Herpes Encephalitis Herpes Simplex Virus 1 Encephalitis
Glaucoma 1, Open Angle, P	GLC1P Primary Open Angle Glaucoma 1p
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 4	FTDALS4 Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-4 Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis, Type 4
Borna Disease	Enzootic Encephalomyelitis
Corticobasal Syndrome
Central Nervous System Disease	CNS Cns Diseases Central Nervous System Diseases Cns Disorder
Encephalopathy, Acute, Infection-Induced 8	Encephalopathy, Acute, Infection-Induced , Susceptibility To, 8 IIAE8 Herpes Simplex Encephalitis 6 Herpes Simplex Encephalitis, Susceptibility To, 6 Encephalopathy, Acute, Infection-Induced, 8, Herpes-Specific Encephalitis, Herpes Simplex, Susceptibility To, Type 6 {Encephalopathy, Acute, Infection-Induced , Susceptibility To, 8}
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male
Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations	Crv Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations Rvcl Rvcl-S Vasculopathy, Retinal, With Cerebral Leukodystrophy Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena Retinal Vasculopathy With Cerebral Leukodystrophy Retinal Vasculopathy And Cerebral Leukoencephalopathy Hereditary Vascular Retinopathy Hvr RVCLS Cerebroretinal Vasculopathy, Hereditary Cerebroretinal Vasculopathy Herns Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly Hereditary Cerebroretinal Vasculopathy Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke Hereditary Systemic Angiopathy Hsa Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations Adrvcl Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Encephalopathy With Basal Ganglia Calcification Aicardi-Goutières Syndrome Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Aphasia
Motor Neuron Disease	Anterior Horn Cell Disease Motor Neuron Diseases Mnd - [Motor Neurone Disease] Lou Gehrig Disease Creeping Palsy Creeping Paralysis Bulbar Motor Neuron Disease Bulbar Syndrome Anterior Horn Cell Disorder Hereditary Motor Neuron Disease
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1	FTDALS1 Frontotemporal Dementia And/Or Motor Neuron Disease Ftdmnd Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia Alsftd Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1 Frontotemporal Dementia With Motor Neuron Disease Ftdals Ftd-Als Ftd-Mnd Frontotemporal Dementia With Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1 Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1 Frontotemporal Lobar Degeneration Grn-Related Frontotemporal Dementia
Lateral Sclerosis	Primary Lateral Sclerosis Adult-Onset Primary Lateral Sclerosis Adult-Onset Pls Motor Neuron Disease Pls Pls - [Primary Lateral Sclerosis] Lateral Spinal Sclerosis Lateral Complete Paralysis Lateral Incomplete Paralysis Lateral Paralysis
Progressive Non-Fluent Aphasia	Non-Fluent Variant Ppa Non-Fluent Primary Progressive Aphasia Agramatic Variant Of Ppa Agramatic Variant Of Primary Progressive Aphasia Progressive Nonfluent Aphasia Primary Progressive Non Fluent Aphasia Primary Progressive Nonfluent Aphasia
Thalamic Neoplasm	Malignant Neoplasm Of Thalamus Malignant Tumor Of Thalamus Tumor Of Thalamus
Covid-19	2019 Novel Coronavirus 2019-Ncov Infection Covid19 Sars-Cov-2 Infection Wuhan Coronavirus Infection Wuhan Seafood Market Pneumonia Virus Infection
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Disease Primary Immunodeficiency Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Open-Angle Glaucoma	Glaucoma Simplex Pigmentary Glaucoma Wide-Angle Glaucoma Glaucoma, Open-Angle Open Angle Glaucoma Glaucoma Open-Angle Chronic Simple Glaucoma Coag - [Chronic Open-Angle Glaucoma] Csg - [Chronic Simple Glaucoma] Poag - [Primary Open-Angle Glaucoma] Oag - [Open-Angle Glaucoma] Chronic Glaucoma Chronic Open Angle Glaucoma Simple Glaucoma Chronic Noncongestive Glaucoma Ltg - [Low Tension Glaucoma] Noncongestive Glaucoma Nonobstructive Glaucoma Normal Pressure Glaucoma Primary Low Tension Glaucoma Low-Tension Glaucoma Residual Stage Low Tension Glaucoma Open Cleft Glaucoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-B0713	Amlexanox	Inhibitor	99.70%	Unkown

Pre-clinical Phase

Bioactive Molecules (30)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-10514	BX795	Inhibitor	99.84%	Unkown
HY-111941	GSK8612	Inhibitor	99.56%	Unkown
HY-13018	MRT67307	Inhibitor	99.56%	Unkown
HY-133117	BAY-985	Inhibitor	99.69%	Unkown
HY-152237	TBK1-IN-1	Inhibitor	99.63%	Unkown
HY-12453	TBK1/IKKε-IN-2	Inhibitor	98.62%	Unkown
HY-156449	STING-IN-7	Inhibitor	98.29%	Unkown
HY-14682	GSK319347A	Inhibitor	99.25%	Unkown
HY-124652	TBK1/IKKε-IN-4	Inhibitor	99.42%	Unkown
HY-176180	PROTAC STING degrader-4	Inhibitor	98.96%	Unkown
HY-13018A	MRT67307 hydrochloride	Inhibitor	/	Unkown
HY-173462	TBK1-IN-2	Inhibitor	98.19%	Unkown
HY-176192	SMU-14a	Inhibitor	/	Unkown
HY-162133	MSA-2-Pt		/	Unkown
HY-133117A	(Rac)-BAY-985	Inhibitor	/	Unkown
HY-181484	STING agonist-50	Activator	/	Unkown
HY-178916	ITA-9	Inhibitor	/	Unkown
HY-180120	UM-203	Inhibitor	/	Unkown
HY-183748	Polθ-IN-11	Activator	/	Unkown
HY-178951	STING-IN-17	Inhibitor	/	Unkown
HY-172620	LIB3S0280	Inhibitor	99.89%	Unkown
HY-183537	KSI-028	Inhibitor	/	Unkown
HY-148483	SR8185	Inhibitor	/	Unkown
HY-178915	ITA-5	Inhibitor	/	Unkown
HY-183099	TBK1 ligand 3		/	Unkown
HY-183098	UNC8209	Degrader	/	Unkown
HY-P1181	Pam2CSK4		/	Unkown
HY-176334	TBK1 ligand 2	Inhibitor	/	Unkown
HY-162963	DN203316	Inhibitor	/	Unkown
HY-U00457	TBK1/IKKε-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TBK1	VGNC	VGNC:47160
Felis catus	TBK1	VGNC	VGNC:65997
Macaca mulatta	TBK1	VGNC	VGNC:78107
Bos taurus	TBK1	VGNC	VGNC:35656
Rattus norvegicus	TBK1	RGD	RGD:1588588
Mus musculus	TBK1	MGD	MGI:1929658
Others	TBK1	NCBI