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Forskolin

(Synonyms: Coleonol; Colforsin; HL 362)
213 Cited Publications
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Based on 213 publication(s) in Google Scholar

Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC50 of 41 nM and an EC50 of 0.5 μM for type I adenylyl cyclase. Forskolin is also an inducer of intracellular cAMP formation. Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy.

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  • Pureté: 99.92%
  • CAS No.: 66575-29-9
  • Formule: C22H34O7
  • Masse moléculaire:410.50
  • Stockage:

    4°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • Forskolin Chemical Structure
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Forskolin Chemical Structure
    Forskolin Chemical Structure
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
  • Experimental Validation Results for Forskolin
CAS No.: 66575-29-9
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2D/3D Cell Culture and DifferentiationIn Vivo Efficacy StudyHistological Imaging/StainingWBRT-PCRCell Proliferation/Viability AssayCell Migration/Invasion Assay
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  • Forskolin Chemical Structure
    Forskolin Chemical Structure
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  • 1/16

    Forskolin purchased from MedChemExpress. Usage Cited in: Neuro Oncol. 2024 Jan 5;26(1):137-152. [Abstract]

    Customer Validation
     CCK-8 cell viability assay of indicated cells after treatment with either vehicle control or forskolin (50 μM) or forskolin (50 μM) + H89 (20 μM) for 48 hours.

  • 1/16

    Forskolin purchased from MedChemExpress. Usage Cited in: Neuro Oncol. 2024 Jan 5;26(1):137-152. [Abstract]

    Customer Validation
     WB analysis of ADAM22 expression in indicated cells after treatment with either forskolin (50 μM), H89 (20 μM), or forskolin(50 μM) + H89(20 μM) for 48 hours.

  • 1/16

    Forskolin purchased from MedChemExpress. Usage Cited in: Neuro Oncol. 2024 Jan 5;26(1):137-152. [Abstract]

    Customer Validation
     Transwell invasion assay of AtT20 and TtT/GF cells after treatment with either vehicle control or forskolin (50 μM) or forskolin (50 μM) + H89 (20 μM) for 48 hours.Scale bar, 100 μm.

  • 1/16

    Forskolin purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Nov;45(11):2290-2299. [Abstract]

    Customer Validation
     Schemes of generating Fsp1-Cre:R26R-loxp-tdTomato mice and drug treatment to induce in situ transdifferentiation. Fsp1-Cre mice were crossed with R26Rloxp-tdTomato mice in which the expression of tdTomato is prevented by a loxP-flanked STOP cassette. The F1 mice would have the red fluorescent protein tdTomato expressed specifically in the fibroblasts. CRFVPTM were given once a week for 6 weeks. Immunofluorescence staining of the cryosections of the hearts from Fsp1-Cre:R26R-loxp-tdTomato mice treated with vehicle (b) or CRFVPTM (c) for 6 weeks. C: CHIR99021, 14 mg/kg; R: RepSox, 8.6 mg/kg; F: Forskolin, 61.6 mg/kg; V: VPA, 250 mg/kg; T: TTNPB, 1 mg/kg and M: Rolipram, 2.5 mg/kg; P: Parnate, 2.7 mg/kg, CRFTM by oral gavage and VP by intraperitoneal injection once a week for 6 weeks in mice at about 8 weeks of age.

  • 1/16

    Forskolin purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Nov;45(11):2290-2299. [Abstract]

    Customer Validation
     Whole-heart imaging with light-sheet fluorescence microscopy after tissue clearing of the hearts from Fsp1-Cre:R26R-loxp-tdTomato mice treated with vehicle (a) or CRFVPTM (b). (C: CHIR99021, 14 mg/kg; R: RepSox, 8.6 mg/kg; F: Forskolin, 61.6 mg/kg; V: VPA, 250 mg/kg; T: TTNPB, 1 mg/kg and M: Rolipram, 2.5 mg/kg; P: Parnate, 2.7 mg/kg, CRFTM by oral gavage and VP by intraperitoneal injection once a week for 6 weeks in mice at about 8 weeks of age).

  • 1/16

    Forskolin purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Nov;45(11):2290-2299. [Abstract]

    Customer Validation
     a Schemes of obtaining PDGFRα-DreER:R26R-rox-tdTomato mice and drug treatment to induce in situ cardiac reprogramming in PDGFRα-DreER:R26R-roxtdTomato mice. PDGFRα-DreER mice were mated with R26R-rox-tdTomato mice in which the expression of tdTomato is prevented by a roxflanked STOP cassette. The expression of tdTomato in fibroblasts was turned on by tamoxifen treatment. CRFVPTM were given once a week for 6 weeks. b Body weigh change of the mice after chemical treatment. Immunofluorescence staining of the cryosections of the hearts from PDGFRα-DreER:R26R-rox-tdTomato mice treated with vehicle (c) or CRFVPTM (d) for 6 weeks. (C: CHIR99021, 14 mg/kg; R: RepSox, 8.6 mg/kg; F: Forskolin, 61.6 mg/kg; V: VPA, 250 mg/kg; T: TTNPB, 1 mg/kg and M: Rolipram, 2.5 mg/kg; P: Parnate, 2.7 mg/kg, CRFTM by oral gavage and VP by intraperitoneal injection once a week for 6 weeks in mice at about 8 weeks of age).

  • 1/16

    Forskolin purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Nov;45(11):2290-2299. [Abstract]

    Customer Validation
     Immunofluorescence staining of α-actinin in cryosections of hearts from Fsp1-Cre:R26R-loxp-tdTomato mice treated with 7 C cocktail (CRFVPTM) or cocktails by removing 1 compound from 7 C (7C-X) for 6 weeks in vivo with Fsp1-Cre:R26R-loxp-tdTomato mice. (C: CHIR99021, 14 mg/kg; R: RepSox, 8.6 mg/kg; F: Forskolin, 61.6 mg/kg; V: VPA, 250 mg/kg; T: TTNPB, 1 mg/kg and M: Rolipram, 2.5 mg/kg; P: Parnate, 2.7 mg/kg, CRFTM by oral gavage and VP by intraperitoneal injection once a week for 6 weeks in mice at about 8 weeks of age).

  • 1/16

    Forskolin purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Aug 9;8(1):290. [Abstract]

    Customer Validation
     Representative Western blot images of eNOS expression in HAECs treated by forskolin (24 h) and H89.

  • 1/16

    Forskolin purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2023 Jul;25(7):937-949. [Abstract]

    Customer Validation
     Forskolin upregulates PLD6 expression. H295R cells were treated without or with 10 µM forskolin for 2 h and then harvested for real-time quantitative PCR analysis.

  • 1/16

    Forskolin purchased from MedChemExpress. Usage Cited in: J Dermatol Sci. 2023 May;110(2):44-52. [Abstract]

    Customer Validation
     Roflumilast (10 or 100 μM), forskolin (20 or 40 μM), and the combination of 10 μM roflumilast with 20 μM forskolin exhibited no toxicity to PIG1 cells after 24 h of treatment.

  • 1/16

    Forskolin purchased from MedChemExpress. Usage Cited in: J Cell Biochem. 2019 Jan;120(1):321-331. [Abstract]

    Customer Validation
     The combination of Fsk and IBMX (Fsk-IBMX) inhibits the expression of cAMP related protein. The results of Western blot in glioma stem cells (GSCs).

  • 1/16

    Forskolin purchased from MedChemExpress. Usage Cited in: J Cell Biochem. 2019 Jan;120(1):321-331. [Abstract]

    Customer Validation
     U0126 enhances the negative effect of Fsk-IBMX on the development of glioma stem cells (GSCs).

  • 1/16

    Forskolin purchased from MedChemExpress. Usage Cited in: J Lipid Res. 2018 Feb;59(2):330-338. [Abstract]

    Customer Validation
     Forskolin (FSK) -stimulated dephsphorylation of HDAC5 is also inhibited by Thapsigargin (THA) treatment in primary hepatocytes.

  • Forskolin