SGC-CAF382-1
Based on 1 Customer Validation
CAF-382 (compound B1) is an analog of SNS-032 and a CDKL5 and pan-CDK inhibitor with a weak GSK3α/β affinity (>1.8 μM) and inhibitory activity. CAF-382 inhibits CDKL5 and blocks the phosphorylation of the CDKL5 E2 domain.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 98.15%
- Formule: C16H22N4O2S2
- Masse moléculaire:366.50
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Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
IC50: ≤100 nM (CDK9, PCTK1/CDK16, PCTK2/CDK17, PCTK3/CDK18), 2.1-2.7 μM (CDKL3, CDKL4)[1]
In Vitro
CAF-382 (compound B1) (5 nM-5 μM) causes a significant reduction in pSer222 EB2 at 5 nM without a change in total EB2 levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Masse moléculaire 366.50
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Formule C16H22N4O2S2
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Color White to light yellow
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SMILES
CC(C1=CN=C(O1)CSC2=CN=C(S2)NC(C3CCNCC3)=O)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureté et documentation
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Fiche technique (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SGC-CAF382-1 Related Classifications
HY-155805 Related Classifications
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