DBr-1
Based on 1 Customer Validation
DBr-1 is a potent BRD9 PROTAC degrader (KD: 13 nM). DBr-1 can overcome intrinsic resistance to VHL-degrader. Blue: DCAF1 binder (HY-149934), Black: linker, Pink: BRD9/BRD7 bromodomains inhibitor (HY-100352).
(Pink: BRD9 ligand (HY-100352); Blue: Cereblon ligand (HY-149934); Black: linker).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.87%
- Formule: C55H68ClN9O5
- Masse moléculaire:970.64
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Chemical Information
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Appearance Solid
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Masse moléculaire 970.64
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Formule C55H68ClN9O5
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Color Off-white to light yellow
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SMILES
COC1=C(C(C2=C3C=NC=C2)=CN(C)C3=O)C=C(OC)C(CN4CCC(OCCCCCC(N5CCN(C6=CC=C7C(N=C(C8(C9=CC=C(Cl)C=C9)CCCCC8)N=C7NCCN)=C6)CC5)=O)CC4)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 100 mg/mL (103.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0302 mL | 5.1512 mL | 10.3025 mL | 25.7562 mL |
| 5 mM | 0.2060 mL | 1.0302 mL | 2.0605 mL | 5.1512 mL | |
| 10 mM | 0.1030 mL | 0.5151 mL | 1.0302 mL | 2.5756 mL | |
| 15 mM | 0.0687 mL | 0.3434 mL | 0.6868 mL | 1.7171 mL | |
| 20 mM | 0.0515 mL | 0.2576 mL | 0.5151 mL | 1.2878 mL | |
| 25 mM | 0.0412 mL | 0.2060 mL | 0.4121 mL | 1.0302 mL | |
| 30 mM | 0.0343 mL | 0.1717 mL | 0.3434 mL | 0.8585 mL | |
| 40 mM | 0.0258 mL | 0.1288 mL | 0.2576 mL | 0.6439 mL | |
| 50 mM | 0.0206 mL | 0.1030 mL | 0.2060 mL | 0.5151 mL | |
| 60 mM | 0.0172 mL | 0.0859 mL | 0.1717 mL | 0.4293 mL | |
| 80 mM | 0.0129 mL | 0.0644 mL | 0.1288 mL | 0.3220 mL | |
| 100 mM | 0.0103 mL | 0.0515 mL | 0.1030 mL | 0.2576 mL |
DBr-1 Related Classifications
HY-156744 Related Classifications
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