NU6310
NU6310 is a non-covalent, ATP-competitive CDK2 inhibitor with an IC50 of 0.16 μM against CDK2. NU6310 can be used for research on cell cycle regulation related to tumors.
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- CAS No.: 1453215-59-2
- Formule: C20H25N5O3S
- Masse moléculaire:415.51
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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CDK2 0.16 μM (IC50) |
NU6310 is a non-covalent, ATP-competitive inhibitor that inhibits the kinase activity of purified CDK2, with an IC50 of 0.16 μM[1].
NU6310 (39-10000 nM; 30-240 seconds) binds reversibly to immobilized CDK2/cyclin A, with a KD of 0.716 μM[2].
NU6310 (overnight incubation) exerts no covalent modification effect on CDK2/cyclin A; it can be completely removed via dialysis, thereby restoring CDK2's kinase activity for the phosphorylation of the Rb protein[2].
NU6310 (50 μM; 1 hour) inhibits the phosphorylation of the Rb protein at the Thr821 site in SKUT-1B cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1453215-59-2
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Masse moléculaire 415.51
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Formule C20H25N5O3S
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SMILES
O=S(C1=CC=C(NC2=NC3=C(C(OCC4CCCCC4)=N2)NC=N3)C=C1)(CC)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NU6310 Related Classifications
HY-182605 Related Classifications
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