1. PROTAC
    Epigenetics
  2. PROTACs
    Epigenetic Reader Domain
  3. dBET23

dBET23 

Cat. No.: HY-123911 Purity: 99.33%
Handling Instructions

dBET23 is a highly effective and selective PROTAC BRD4 degrader with a DC50/5h of ~ 50 nM for BRD4BD1 protein.

For research use only. We do not sell to patients.

dBET23 Chemical Structure

dBET23 Chemical Structure

CAS No. : 1957234-83-1

Size Price Stock Quantity
1 mg USD 390 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
25 mg USD 3600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 5800 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

dBET23 is a highly effective and selective PROTAC BRD4 degrader with a DC50/5h of ~ 50 nM for BRD4BD1 protein[1].

In Vitro

dBET23 occupies the canonical binding sites on CRBN and BRD4BD1 for thalidomide and JQ1, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

885.38

Formula

C₄₃H₄₅ClN₈O₉S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 170 mg/mL (192.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1295 mL 5.6473 mL 11.2946 mL
5 mM 0.2259 mL 1.1295 mL 2.2589 mL
10 mM 0.1129 mL 0.5647 mL 1.1295 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 4.25 mg/mL (4.80 mM); Suspended solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
dBET23
Cat. No.:
HY-123911
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