Dihydroartemisinin-d5
Dihydroartemisinin-d5 (Dihydroqinghaosu-d5) is the d5-labeled Dihydroartemisinin (HY-N0176). Dihydroartemisinin is an orally active metabolite of rtemisinin (HY-B0094) and antimalarial agent. Dihydroartemisinin induces Autophagy by inhibiting NF-κB activation. Dihydroartemisinin promotes ROS accumulation. Dihydroartemisinin exhibits anticancer activity in esophageal cancer cells. Dihydroartemisinin shows schistosomicidal activity against juvenile and adult worms of Schistosoma japonicum, reduces worm burden, and displays antiparasitic activity. Dihydroartemisinin can be used in research related to multiple myeloma, promyelocytic leukemia, esophageal cancer, and Schistosoma japonicum infection.
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- Fòrmula: C15H19D5O5
- Peso molecular:289.38
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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Schistosome |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 71939-50-9
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Peso molecular 289.38
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Fòrmula C15H19D5O5
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SMILES
[2H][C@](O1)(O)[C@@](C([2H])([2H])[2H])([2H])C2CC[C@@H](C)C3CC[C@@]4(C)OO[C@]32[C@H]1O4
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Synonyms
Dihydroqinghaosu-d5; β-Dihydroartemisinin-d5; Artenimol-d5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Hu W, et al. Dihydroartemisinin induces autophagy by suppressing NF-κB activation. Cancer Lett. 2014;343(2):239-248. [Content Brief]
[2]. Li YJ, et al. Dihydroartemisinin accentuates the anti-tumor effects of photodynamic therapy via inactivation of NF-κB in Eca109 and Ec9706 esophageal cancer cells. Cell Physiol Biochem. 2014;33(5):1527-1536. [Content Brief]
[3]. Li HJ, et al. Dihydroartemisinin-praziquantel combinations and multiple doses of dihydroartemisinin in the treatment of Schistosoma japonicum in experimentally infected mice. Ann Trop Med Parasitol. 2011 Jun;105(4):329-33. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dihydroartemisinin-d5 Related Classifications
HY-N0176S3 Related Classifications
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- Dihydroartemisinin-d5
- Dihydroqinghaosu-d5
- β-Dihydroartemisinin-d5
- Artenimol-d5
- Isotope-Labeled Compounds
- Parasite
- NF-κB
- Autophagy
- Reactive Oxygen Species (ROS)
- Drug Metabolite
- RelA/p65
- NB4 cells
- HCT116 cells
- RPMI 8226 cells
- esophageal cancer cells
- autophagy
- IκBα
- Schistosoma japonicum
- HeLa cells
- Inhibitor
- inhibitor
- inhibit