dCeMM3
Based on 1 Customer Validation
dCeMM3 (Compound 3) is a molecular glue degrader. dCeMM3 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex.
For research use only. We do not sell to patients.
- Purity: 98.19%
- CAS No.: 311787-85-6
- Formula: C14H11ClN4OS
- Molecular Weight:318.78
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
dCeMM3 (0.01–100 µM, 3 days) exhibits significant cytotoxicity in wild-type KBM7 cells, and its effect was dependent on UBE2M activity[1]. dCeMM3 (7 µM, 5 hours) significantly reduces Cyclin K levels in KBM7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:KBM7 cells
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Concentration:7 µM
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Incubation Time:5 hours
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Result:Significantly reduced cyclin K levels.
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Cell Line:KBM7 wild-type (WT) and UBE2M mutant cells
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Concentration:0.01-100 µM
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Incubation Time:3 days
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Result:Showed significant cytotoxicity in WT cells but greatly reduced cytotoxicity in UBE2M mutant cells.
Chemical Information
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CAS No. 311787-85-6
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Appearance Solid
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Molecular Weight 318.78
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Formula C14H11ClN4OS
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Color Light brown to brown
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SMILES
O=C(NC1=NC=C(Cl)C=C1)CSC2=NC3=CC=CC=C3N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (156.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.84 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.1370 mL | 15.6848 mL | 31.3696 mL | 78.4240 mL |
| 5 mM | 0.6274 mL | 3.1370 mL | 6.2739 mL | 15.6848 mL | |
| 10 mM | 0.3137 mL | 1.5685 mL | 3.1370 mL | 7.8424 mL | |
| 15 mM | 0.2091 mL | 1.0457 mL | 2.0913 mL | 5.2283 mL | |
| 20 mM | 0.1568 mL | 0.7842 mL | 1.5685 mL | 3.9212 mL | |
| 25 mM | 0.1255 mL | 0.6274 mL | 1.2548 mL | 3.1370 mL | |
| 30 mM | 0.1046 mL | 0.5228 mL | 1.0457 mL | 2.6141 mL | |
| 40 mM | 0.0784 mL | 0.3921 mL | 0.7842 mL | 1.9606 mL | |
| 50 mM | 0.0627 mL | 0.3137 mL | 0.6274 mL | 1.5685 mL | |
| 60 mM | 0.0523 mL | 0.2614 mL | 0.5228 mL | 1.3071 mL | |
| 80 mM | 0.0392 mL | 0.1961 mL | 0.3921 mL | 0.9803 mL | |
| 100 mM | 0.0314 mL | 0.1568 mL | 0.3137 mL | 0.7842 mL |
dCeMM3 Related Classifications
HY-144976 Related Classifications
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