STAT6 - signal transducer and activator of transcription 6 Gene

Also Known as STAT6B; STAT6C; D12S1644; IL-4-STAT

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6778

About STAT6

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:57,095,408-57,111,362 (from NCBI)

This gene has 25 transcripts (splice variants), 190 orthologues, 6 paralogues and is associated with 75 phenotypes. Ubiquitous expression in spleen (RPKM 48.4), skin (RPKM 47.3) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to Cytokines and Growth Factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

STAT6 Products (11)

mRNA	Protein	Name
XM_047429477.1	XP_047285433.1	signal transducer and activator of transcription 6 isoform X3
NM_001178078.2	NP_001171549.1	signal transducer and activator of transcription 6 isoform 1
NM_001178081.2	NP_001171552.1	signal transducer and activator of transcription 6 isoform 2
XM_047429474.1	XP_047285430.1	signal transducer and activator of transcription 6 isoform X1
XM_047429473.1	XP_047285429.1	signal transducer and activator of transcription 6 isoform X1
NR_033659.2
NM_003153.5	NP_003144.3	signal transducer and activator of transcription 6 isoform 1
XM_047429476.1	XP_047285432.1	signal transducer and activator of transcription 6 isoform X2
NM_001178079.2	NP_001171550.1	signal transducer and activator of transcription 6 isoform 1
NM_001178080.2	NP_001171551.1	signal transducer and activator of transcription 6 isoform 2
XM_047429475.1	XP_047285431.1	signal transducer and activator of transcription 6 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8810328	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	8816495	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	36884218	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8810328	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	22000020	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8816495	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	17210636	GOA
enables transcription coactivator binding	EXP EXP: Inferred from Experiment	29203888	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell surface receptor signaling pathway via JAK-STAT	IMP IMP: Inferred from mutant phenotype	12574355	GOA
involved in cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	36884218	GOA
involved in interleukin-4-mediated signaling pathway	IDA IDA: Inferred from direct assay	7760829	GOA
involved in interleukin-4-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	12574355	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8810328	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12574355	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	22000020	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	7694370	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	36758835	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STAT6 Protein Structure

STAT_int

STAT_alpha

STAT_bind

SH2

STAT6_C

0
200
400
600
800
847 a.a.

Protein Preferred Names	Protein Names
signal transducer and activator of transcription 6	STAT, interleukin4-induced signal transducer and activator of transcription 6, interleukin-4 induced transcription factor IL-4 STAT

STAT6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STAT6	P42226	TBK1	Homo sapiens	Q9UHD2	Anti Bait CoIP	22000020
Intra	STAT6	P42226	STING1	Homo sapiens	Q86WV6	Anti Bait CoIP	22000020
Intra	STAT6	P42226	TBK1	Homo sapiens	Q9UHD2	Anti Tag CoIP	22000020
Intra	STAT6	P42226	NMI	Homo sapiens	Q13287	Y2H Array	20211142
Intra	STAT6	P42226	IL4R	Homo sapiens	P24394	FPS	8816495
Intra	STAT6	P42226	TBK1	Homo sapiens	Q9UHD2	Protein Kinase Assay	22000020
Intra	STAT6	P42226	STING1	Homo sapiens	Q86WV6	Anti Tag CoIP	22000020
Intra	STAT6	P42226	IL4R	Homo sapiens	P24394	Pull Down	9392697

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant STAT6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71337	STAT6 Protein, Human (His)	P42226 (S627-S837)	≥ 90%, as determined by reducing SDS-PAGE.

STAT6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80347	STAT6 Antibody (YA051)	WB, ICC/IF, IHC-P, IP	Human, Mouse, Rat
HY-P84314	STAT6 Antibody (YA4011)	WB, ICC/IF, ELISA	Human, Mouse, Rat, Monkey
HY-P84314A	STAT6 Antibody (YA4011)(PBS only)	WB, ICC/IF, ELISA	Human, Mouse, Rat, Monkey
HY-P85377	STAT6 Antibody (YA5069)	WB; IHC-P; IHC-F; IF-Tissue	Human, Mouse, Rat
HY-P86241	STAT6 Antibody (YA5933)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Inflammatory Myofibroblastic Tumor	Inflammatory Fibrosarcoma
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified
Ige Responsiveness, Atopic	ATOPY Atopy, Susceptibility To Ige, Elevated Level Of IGER Immunoglobulin E, Basic Level Of, In Serum Ige, Level Of Igel Ige Response Underlying Allergic Asthma And Rhinitis Atopic Hypersensitivity Immediate Hypersensitivity
Colitis
Nasal Cavity Disease	Disorder Of Nasal Cavity
Secondary Hypertrophic Osteoarthropathy	Osteoarthropathy, Secondary Hypertrophic Bamberger-Marie Disease Hpoa - Hypertrophic Pulmonary Osteoarthropathy Hypertrophic Pulmonary Osteoarthropathy Marie Bamberger Disease
Myxofibrosarcoma	Fibromyxosarcoma Fibromyxoid Sarcoma Myxoid Malignant Fibrous Histiocytoma Dermatofibrosarcoma Protuberans, Myxoid
Ulcerative Colitis	Colitis Gravis Left Sided Ulcerative Colitis Left-Sided Ulcerative Colitis Idiopathic Proctocolitis Inflammatory Bowel Disease, Ulcerative Colitis Type Uc Colitis Ulcerative Colitis, Ulcerative Chronic Left-Sided Ulcerative Colitis Uc - [Ulcerative Colitis] Chronic Ulcerative Enteritis Mucosal Proctocolitis Ulcerative Mucosal Proctocolitis Left Hemicolitis
Dedifferentiated Liposarcoma	Ddls Liposarcoma Dedifferentiated Liposarcoma, Dedifferentiated
Dermatitis	Eczema Skin Inflammation Inflammatory Dermatosis
Esophagitis, Eosinophilic, 1	Eosinophilic Esophagitis EOE1 Esophagitis, Eosinophilic Ee
Severe Combined Immunodeficiency, X-Linked	X-Linked Severe Combined Immunodeficiency SCIDX1 XSCID Scidx X-Linked Scid X-Scid Severe Combined Immunodeficiency, X-Linked, T Cell-Negative, B Cell-Positive, Nk Cell-Negative Scid, X-Linked Immunodeficiency 4 Imd4 Gamma Chain Deficiency Scid-X1 X-Linked Combined Immunodeficiency Diseases Thymic Epithelial Hypoplasia Severe Combined Immunodeficiency T- B+ Due To Gamma Chain Deficiency Severe Combined Immunodeficiency T- B+, X-Linked Il2rg Scid, T- B+ Nk- T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency T-B+ Scid Due To Gamma Chain Deficiency T-B+ Severe Combined Immunodeficiency, X-Linked Severe Combined Immunodeficiency X-Linked T-Cell-Negative/B-Cell-Positive/Nk-Cell-Negative Agammaglobulinemia Swiss Type Scid X-Linked Severe Combined Immunodeficiency X-Linked T Cell-Negative/B Cell-Positive/Nk Cell-Negative Severe Combined Immunodeficiency X-Linked T-Cell Negative/B-Cell Positive/Nk-Cell Negative Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Primary Mediastinal B-Cell Lymphoma	Large Cell Lymphoma Of The Mediastinum Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Spindle Cell Lipoma
Vagina Sarcoma	Sarcoma Of The Vagina Vaginal Sarcoma
Potter'S Syndrome	Potter Syndrome Potter Sequence Oligohydramnios Sequence Congenital Absence Of Kidneys Syndrome
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Vascular Cancer	Blood Vessel Tumors Malignant Vascular Neoplasm Renal Vein Leiomyosarcoma Vascular Neoplasms Blood Vessel Neoplasm Blood Vessel Tumor Blood Vessel Tumour Disorder Haemangiomatous Tumour Leiomyosarcoma Of The Renal Vein Malignant Great Vessel Tumor Malignant Tumor Of Pulmonary Artery Malignant Tumor Of Pulmonary Vein Malignant Vascular Tumor Neoplasm Of Great Vessel Pulmonary Artery Malignant Neoplasm Pulmonary Vein Malignant Neoplasm Vascular Tissue Neoplasm Vascular Tumors Blood Vessel Cancer Neoplasms, Vascular Tissue Malignant Neoplasm Of Great Vessels
Contact Dermatitis	Contact Dermatitis/Eczema Contact Eczema Dermatitis Venenata Dermatitis, Venenata Dermatitis Contact Dermatitis, Contact
Cardiomyopathy, Familial Restrictive, 1	RCM1 Restrictive Cardiomyopathy 1 Rcm Familial Restrictive Cardiomyopathy 1 Cardiomyopathy, Familial Restrictive 1 Cardiomyopathy, Restrictive, Familial, Type 1 Rcm-1
Pericytoma With T(7;12)
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Parasitic Helminthiasis Infectious Disease	Helminthiasis Intestinal Helminthiasis Helminth Infection Helminthosis Worm Infection Worm Infections Helminth Infections Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata Parasitic Enteritis Metazoal Dysentery Intestinal Worms Nos
Neurofibroma Of The Heart	Neurofibroma Of Heart
Co-Trimoxazole Allergy	Bactrim Allergy Cotrimoxazol Allergy Tmp/Smx Allergy Trimethoprim/Sulfamethoxazole Allergy
Carbapenem Allergy
Solitary Fibrous Tumor/Hemangiopericytoma	Sft/Hpc
Allergic Contact Dermatitis	Dermatitis, Allergic Contact Contact Dermatitis, Allergic Dermatitis Allergic Contact Allergic Contact Eczema Acd - [Allergic Contact Dermatitis] Allergic Contact Dermatitis, Unspecified Cause Allergic Dermatitis Allergic Eczema Allergy Dermatitis Allergy Eczema Allergic Contact Eczema Due To Clothing Or Footwear Perfume Allergic Contact Dermatitis Allergic Contact Dermatitis Due To Cosmetics Allergic Contact Eczema Due To Cosmetics Or Fragrances Allergic Contact Eczema Due To Dental Materials Allergic Contact Eczema Due To Food Flavours Or Additives Allergic Contact Eczema Due To Hairdressing Products Allergic Contact Eczema Due To Metals Or Metal Salts Allergic Contact Eczema Due To Proteins Allergic Contact Eczema Due To Plastics Or Resin Systems Allergic Contact Eczema Due To Preservatives Or Biocides Allergic Contact Eczema Due To Rubber Chemicals Rubber Dermatitis Allergic Contact Eczema Due To Systemic Medicaments Allergic Contact Eczema Due To Topical Medicaments Allergic Contact Dermatitis Due To Drugs In Contact With Skin
Trigeminal Nerve Neoplasm	Neoplasm Of Trigeminal Nerve Tumor Of Trigeminal Nerve
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Esophagitis	Acute Esophagitis
Myofibroma	Lipoleiomyoma Uterine Fibroids Solitary Myofibromatosis Myolipoma
Diffuse Large B-Cell Lymphoma Activated B-Cell Type	Dlbcl Abc Type
Benign Fibrous Mesothelioma	Fibrous Mesothelioma, Benign Localized Benign Fibrous Mesothelioma Solitary Fibrous Tumor, Pleural Pleural Solitary Fibrous Tumor Solitary Fibrous Tumor
Vaginal Endometrial Stromal Sarcoma
Allergic Asthma	Atopic Asthma Extrinsic Asthma Extrinsic Asthma With Acute Exacerbation Extrinsic Asthma With Status Asthmaticus Asthma Allergic Atopic Asthma, Susceptibility To Ige-Mediated Allergic Asthma Allergen-Induced Asthma Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Allergic Asthma Nos Catarrh With Asthma Allergic Bronchitis Nos Extrinsic Allergic Asthma Predominantly Allergic Asthma With Stated Status Asthmaticus
Phenytoin Allergy	Dilantin Allergy
Prostate Signet Ring Cell Adenocarcinoma	Prostate Signet Ring Cell Carcinoma Signet Ring Cell Carcinoma Of Prostate Acinar Prostate Adenocarcinoma, Signet Ring Variant
Meninges Hemangiopericytoma	Hemangiopericytoma Of Meninges Meningeal Hemangiopericytoma
Respiratory Allergy	Airway Allergy
Hemangiopericytoma, Malignant	Hemangiopericytoma Haemangiopericytic Meningioma Malignant Hemangiopericytoma Solitary Fibrous Tumor
Liposarcoma	Lipomatous Cancer
Mesenchymal Cell Neoplasm	Benign Miscellaneous Mesenchymal Tumor Mesenchymal Tumor Mesenchymal Tumors
Myxoid Liposarcoma	Myxoid/Round Cell Liposarcoma Liposarcoma, Myxoid Mrcls Myxoliposarcoma MXLIPO Liposarcoma Myxoid Liposarcoma
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Testicular Fibroma
Fibrous Meningioma	Fibroblastic Meningioma
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Neurilemmoma Of The Fifth Cranial Nerve	Trigeminal Schwannoma Trigeminal Neurilemmoma
Dermatofibrosarcoma Protuberans	DFSP Dermatofibrosarcoma Giant Cell Fibroblastoma Metastatic Dermatofibrosarcoma Protuberans Familial Dermatofibrosarcoma Protuberans Darier-Ferrand Tumor Darier-Hoffmann Tumor
Trichinosis	Trichinellosis Human Trichinellosis Trichiniasis Trichinella Spiralis Infection Infection With Trichinella Trichinelliasis Trichinella Spiralis Infestation
Inflammatory Bowel Disease 24	IBD24
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Inflammatory Bowel Disease 2	IBD2
Well-Differentiated Liposarcoma	Atypical Lipomatous Tumor Atypical Lipoma Alt Wdls Liposarcoma, Well Differentiated Pleomorphic Lipoma
Small Cell Sarcoma	Sarcoma, Small Cell
Pseudosarcomatous Fibromatosis	Nodular Fasciitis Pseudosarcomatous Fasciitis Fasciitis - Nodular Fasciitis Nodular
Chronic Asthma
Perivascular Tumor	Malignant Perivascular Cancer
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Disease Primary Immunodeficiency Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Schistosomiasis	Katayama Fever Bilharzia Bilharziasis Schistosomiasis Mansoni Blood Fluke Schistosoma Mansoni Infection Snail Fever Acute Schistosomiasis Schistosomiasis Manson Schistosomiasis Due To Schistosoma Mansoni [Intestinal Schistosomiasis] Intestinal Schistosomiasis Nos Intestinal Schistosomiasis Egyptian Splenomegaly Bilharziasis Of Intestine Schistosomal Dysentery Schistosomiasis Of Colon Asiatic Schistosomiasis Eastern Schistosomiasis Schistosoma Japonicum Infection Schistosomiasis Japonicum Katayama Disease Katayama Syndrome Oriental Schistosomiasis
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Bronchial Disease	Bronchial Diseases Bronchial Disorders Bronchial Spasm
Thymus Sarcomatoid Carcinoma	Thymic Carcinosarcoma Thymic Sarcomatoid Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100754	Ritlecitinib	Inhibitor	99.80%	Yes
HY-B1076	Medrysone	Modulator	99.79%	Unkown
HY-100754C	Ritlecitinib tosylate	Inhibitor	99.65%	Yes
HY-112961	Patiromer	Inhibitor	95.0%	Unkown
HY-100754A	Ritlecitinib malonate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-123823	Nitroaspirin	Inhibitor	98.57%	Phase 2

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990093	Stapokibart	Inhibitor	99.37%	Phase 4
HY-P990090	Rademikibart	Inhibitor	99.13%	Phase 3

Pre-clinical Phase

Bioactive Molecules (39)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100614	AS1517499	Inhibitor	99.21%	Unkown
HY-169179	AK-1690	Degrader	99.91%	Unkown
HY-113402	Gamma-glutamylcysteine	Activator	98.53%	Unkown
HY-134771	YM-341619	Inhibitor	98.01%	Unkown
HY-173236	STAT4-IN-1	Inhibitor	99.17%	Unkown
HY-158399	STAT6-IN-5	Inhibitor	99.88%	Unkown
HY-158398	STAT6-IN-4	Inhibitor	99.77%	Unkown
HY-134772	AS1810722	Inhibitor	98.10%	Unkown
HY-169182	AK-068	Ligand	99.57%	Unkown
HY-169360	SD-436	Degrader	98.27%	Unkown
HY-177456	STAT6 degrader-3	Degrader	99.26%	Unkown
HY-176857	PROTAC STAT6 degrader-1	Degrader	99.55%	Unkown
HY-117548	UNC1062	Inhibitor	98.92%	Unkown
HY-N0407	Picroside I	Inhibitor	99.31%	Unkown
HY-176864	STAT6 ligand-1	Ligand	98.94%	Unkown
HY-206870	BP79	Inhibitor	/	Unkown
HY-176949	STAT6-IN-10	Inhibitor	98.81%	Unkown
HY-113509B	15(R)-Lipoxin A4	Inhibitor	98.3%	Unkown
HY-123115	Leucrose		98.53%	Unkown
HY-182359	YYSW001	Inhibitor	/	Unkown
HY-183837	PROTAC STAT6 degrader-8	Degrader	/	Unkown
HY-183834	PROTAC STAT6 degrader-7	Degrader	/	Unkown
HY-183733	STAT6 degrader-4	Degrader	/	Unkown
HY-183847	PROTAC STAT6 degrader-10	Degrader	/	Unkown
HY-162404	(14S,15R)-14-Deoxyoxacyclododecindione	Inhibitor	/	Unkown
HY-179233	PROTAC STAT6 degrader-2	Degrader	/	Unkown
HY-171441	STAT6 degrader-1	Degrader	/	Unkown
HY-185073	STAT6-IN-11	Inhibitor	/	Unkown
HY-181901	PROTAC STAT6 degrader-4	Degrader	/	Unkown
HY-183839	PROTAC STAT6 degrader-9	Degrader	/	Unkown
HY-W1113771	STAT6-IN-7	Inhibitor	99.53%	Unkown
HY-184991	AK305	Ligand	/	Unkown
HY-175650	STAT6-IN-9	Inhibitor	98.11%	Unkown
HY-184119	Pabgraminone C	Modulator	/	Unkown
HY-164216	STAT6-IN-13	Inhibitor	/	Unkown
HY-W1113770	STAT6-IN-8	Inhibitor	/	Unkown
HY-162405	STAT6-IN-12	Inhibitor	/	Unkown
HY-182699	PROTAC STAT6 degrader-5	Degrader	/	Unkown
HY-164216A	(trans)-STAT6-IN-13	Modulator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	STAT6	VGNC	VGNC:35374
Felis catus	STAT6	VGNC	VGNC:65763
Rattus norvegicus	STAT6	RGD	RGD:1309063
Canis familiaris	STAT6	VGNC	VGNC:46892
Mus musculus	STAT6	MGD	MGI:103034
Macaca mulatta	STAT6	VGNC	VGNC:77908
Others	STAT6	NCBI