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GsMTx4 TFA

124 Cited Publications
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Based on 124 publication(s) in Google Scholar

GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 TFA also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 TFA is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology.

For research use only. We do not sell to patients.

  • Purity: 99.85%
  • Formula: C185H273N49O45S6.xC2HF3O2
  • Molecular Weight:4095.84 (free base)
  • Storage:

    Sealed storage, away from moisture and light.

    Powder   -80°C, 2 years , -20°C, 1 year

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

  • GsMTx4 TFA Chemical Structure
    GsMTx4 TFA Chemical Structure
  • Experimental Validation Results for GsMTx4 TFA
  • Experimental Validation Results for GsMTx4 TFA
  • Experimental Validation Results for GsMTx4 TFA
  • Experimental Validation Results for GsMTx4 TFA
  • Experimental Validation Results for GsMTx4 TFA
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Flow CytometryCell Proliferation/Viability AssayIn Vivo Efficacy StudyWBCell Migration/Invasion Assay
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  • In Vivo Efficacy Study
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  • Cell Migration/Invasion Assay
  • Cell Proliferation/Viability Assay

All TRP Channel Isoforms

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  • GsMTx4 TFA Chemical Structure
    GsMTx4 TFA Chemical Structure
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    GsMTx4 TFA purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Aug 21;10(1):269. [Abstract]

    Customer Validation
     Flow cytometry analysis showing that Yoda1-induced Ca²⁺ influx is blocked by GsMTx4（0-1 μM; 120 s）.

  • 1/16

    GsMTx4 TFA purchased from MedChemExpress. Usage Cited in: Nat Biotechnol. 2025 Nov 10. [Abstract]

    Customer Validation
     Administration of GsMTx4 (5 μM; 5 μL) reduced the blood product clearance of UDC, as assessed by hematoma volumes across treatment groups.

  • 1/16

    GsMTx4 TFA purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Mar 8;16(1):2329. [Abstract]

    Customer Validation
     Phospho-RAB10 (T73) signal measured by western blot in WT Henle 407 cells. The cells were treated with the PIEZO1 inhibitor GsMTx4 (10 μM; 30 min), LPS and/or the PIEZO1 agonist Yoda1, and cell lysates were collected and immunoblotted for phospho-RAB10 (T73), total RAB10, or ß-actin (loading control) .

  • 1/16

    GsMTx4 TFA purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jul 25;16(1):6868. [Abstract]

    Customer Validation
     GsMTx4（5 μM; 30 min）- treated BxPC3 DUOX1/2 WT cells, green lines indicate initial wound edges at t = 0 h, red lines indicate wound edges at the indicated timepoints, red arrows show area of damaged cells.

  • 1/16

    GsMTx4 TFA purchased from MedChemExpress. Usage Cited in: Cell. 2024 Jun 20;187(13):3409-3426.e24. [Abstract]

    Customer Validation
     WT CD8⁺ T cells treated with DMSO or a Piezo1 inhibitor (GsMTx4, 5 μM; 2 h).

  • GsMTx4 TFA