PNP - purine nucleoside phosphorylase Gene

Also Known as NP; PUNP; PRO1837

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4860

About PNP

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,469,406-20,477,089 (from NCBI)

This gene has 11 transcripts (splice variants), 540 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in bone marrow (RPKM 94.2), kidney (RPKM 44.4) and 18 other tissues.

Summary

This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside Phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Jul 2008]

PNP Products (1)

mRNA	Protein	Name
NM_000270.4	NP_000261.2	purine nucleoside phosphorylase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	20212140	GOA
enables nucleoside binding	IDA IDA: Inferred from direct assay	9305962	GOA
enables phosphate ion binding	IDA IDA: Inferred from direct assay	18938130	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA
enables purine nucleobase binding	IDA IDA: Inferred from direct assay	9305962	GOA
enables purine-nucleoside phosphorylase activity	IDA IDA: Inferred from direct assay	3029074	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in IMP catabolic process	IDA IDA: Inferred from direct assay	6771276	GOA
involved in allantoin metabolic process	IDA IDA: Inferred from direct assay	6771276	GOA
involved in dAMP catabolic process	IDA IDA: Inferred from direct assay	6771276	GOA
involved in deoxyadenosine catabolic process	IDA IDA: Inferred from direct assay	6771276	GOA
involved in deoxyinosine catabolic process	IDA IDA: Inferred from direct assay	6771276	GOA
involved in immune response	IMP IMP: Inferred from mutant phenotype	16930574	GOA
acts upstream of or within inosine catabolic process	IDA IDA: Inferred from direct assay	16964310	GOA
involved in inosine catabolic process	IDA IDA: Inferred from direct assay	23438750	GOA
involved in nicotinamide riboside catabolic process	IDA IDA: Inferred from direct assay	19001417	GOA
involved in nucleobase-containing compound metabolic process	IDA IDA: Inferred from direct assay	3029074	GOA
involved in nucleotide biosynthetic process	IGI IGI: Inferred from genetic interaction	19001417	GOA
acts upstream of or within positive regulation of T cell proliferation	IDA IDA: Inferred from direct assay	16964310	GOA
acts upstream of or within positive regulation of alpha-beta T cell differentiation	IDA IDA: Inferred from direct assay	16964310	GOA
involved in positive regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	16930574	GOA
involved in purine-containing compound salvage	IDA IDA: Inferred from direct assay	18938130	GOA
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	15047506	GOA
acts upstream of or within urate biosynthetic process	IDA IDA: Inferred from direct assay	16964310	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	3029074	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PNP Protein Structure

PNP_UDP_1

0
100
200
289 a.a.

Protein Preferred Names	Protein Names
purine nucleoside phosphorylase	HEL-S-156an

PNP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	PNP	P00491	SORL1	Homo sapiens	Q92673	Validated Y2H	32814053
Intra	PNP	P00491	SORL1	Homo sapiens	Q92673	Y2H Pooling	32814053
Intra	PNP	P00491	SORL1	Homo sapiens	Q92673	Y2H Array	32814053
Intra	PNP	P00491	PINK1	Homo sapiens	Q9BXM7	Y2H Pooling	32814053
Intra	PNP	P00491	PINK1	Homo sapiens	Q9BXM7	Validated Y2H	32814053
Intra	PNP	P00491	PINK1	Homo sapiens	Q9BXM7	Y2H Array	32814053
Intra	PNP	P00491	PNP	Homo sapiens	P00491	Y2H Array	25502805
Intra	PNP	P00491	PNP	Homo sapiens	P00491	Y2H Array	32296183
Intra	PNP	P00491	PNP	Homo sapiens	P00491	Validated Y2H	32296183
Intra	PNP	P00491	PNP	Homo sapiens	P00491	X-Ray Diffraction	20212140
Intra	PNP	P00491	PNP	Homo sapiens	P00491	Y2H Array	31515488
Intra	PNP	P00491	PNP	Homo sapiens	P00491	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PNP Proteins

Referencia número	Nombre del producto	Accession	Pureza
HY-P74665	Nucleoside phosphorylase/PNP Protein, Human (His)	P00491 (M1-S289)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Purine Nucleoside Phosphorylase Deficiency	Purine-Nucleoside Phosphorylase Deficiency Pnp Deficiency Nucleoside Phosphorylase Deficiency Immunodeficiency Due To Purine Nucleoside Phosphorylase Deficiency Deficiency Of Inosine Phosphorylase Pnpase Deficiency PNPD
Adenosine Deaminase Deficiency	Ada Deficiency Ada-Scid Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency Adenosine Deaminase Deficient Severe Combined Immunodeficiency Scid Due To Ada Deficiency Severe Combined Immunodeficiency Due To Ada Deficiency Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency Ada Scid Due To Adenosine Deaminase Deficiency
Lesch-Nyhan Syndrome	Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency LNS Hprt Deficiency Complete Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency Hypoxanthine Guanine Phosphoribosyltransferase Deficiency X-Linked Hyperuricemia Choreoathetosis Self-Mutilation Syndrome Hprt1 Deficiency Hprt Deficiency, Complete Deficiency Of Imp Pyrophosphorylase Hgprt Deficiency Lesch-Nyhan Disease Hypoxanthine Guanine Phosphoribosyltransferase 1 Deficiency Hg-Prt Deficiency Hypoxanthine-Guanine-Phosphoribosyltransferase Deficiency Lesch - Nyhan Syndrome Hprt1 Disorders Lesch Nyhan Syndrome Complete Hprt Deficiency Complete Lesch Nyhan Disease Complete Hprt Deficiency Deficiency Of Guanine Phosphoribosyltransferase Deficiency Of Hypoxanthine Phosphoribosyltransferase Hypoxanthine Phosphoribosyltransferase Deficiency Juvenile Gout, Choreoathetosis, Mental Retardation Syndrome Juvenile Hyperuricemia Syndrome Lnd Primary Hyperuricemia Syndrome Total Hprt Deficiency Total Hypoxanthine-Guanine Phosphoribosyl Transferase Deficiency X-Linked Primary Hyperuricemia X-Linked Uric Aciduria Enzyme Defect Hprt Complete Deficiency Hprt Deficiency Grade Iv Hypoxanthine Guanine Phosphoribosyltransferase Complete Deficiency Hypoxanthine Guanine Phosphoribosyltransferase Deficiency, Grade Iv Hypoxanthine-Guanine Phosphoribosyltransferase 1 Deficiency Hprt - [ Hypoxanthine-Guanine Phosphoribosyltransferase] Complete Deficiency Total Hgprt - [Hypoxanthine-Guanine Phosphoribosyltransferase] Deficiency
Molybdenum Cofactor Deficiency	Combined Molybdoflavoprotein Enzyme Deficiency Mocod Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase, And Aldehyde Oxidase Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase And Aldehyde Oxidase Combined Xanthine Oxidase And Sulfite Oxidase And Aldehyde Oxidase Deficiency Deficiency Of Molybdenum Cofactor Deficiency, Molybdenum Cofactor
Purine-Pyrimidine Metabolic Disorder	Inborn Errors Of Purine-Pyrimidine Metabolism Disorder Of Purine Or Pyrimidine Metabolism
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Gout	Gouty Arthritis Articular Gout Gouty Arthropathy Arthritis, Gouty Arthritis Gouty Idiopathic Gout Idiopathic Gout, Unspecified Site Gouty Bursitis Uratic Arthritis Gout Nos Gouty Gouty Diathesis
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
Pellagra	Niacin Deficiency Niacin-Tryptophan Deficiency Pellagroid Syndrome
Primary Cutaneous T-Cell Non-Hodgkin Lymphoma	Cutaneous T-Cell Lymphoma Cutaneous T Cell Lymphoma Lymphoma, T-Cell, Cutaneous Ctcl Lymphoma T-Cell Cutaneous
Hyperuricemia, Hprt-Related	Hprt-Related Gout Kelley-Seegmiller Syndrome Hprt Deficiency, Partial HRH Gout, Hprt-Related Hprt1 Deficiency, Partial Hrpt-Related Hyperuricemia Hprt Deficiency, Grade I Hprt Partial Deficiency Hprt-Related Hyperuricemia Hprt1 Partial Deficiency Hypoxanthine Guanine Phosphoribosyltransferase 1 Partial Deficiency Hypoxanthine Guanine Phosphoribosyltransferase Deficiency, Grade I Hypoxanthine Guanine Phosphoribosyltransferase Partial Deficiency Partial Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency Hypoxanthine Guanine Phosphoribosyltransferase 1 Deficiency, Partial Hyperuricemia, Hrpt-Related
Reticular Dysgenesis	Severe Combined Immunodeficiency With Leukopenia De Vaal Disease Congenital Aleukia Aleukocytosis Hematopoietic Hypoplasia, Generalized Reticular Dysgenesia Devaal Disease Rd Ak2 Deficiency Congenital Aleukocytosis Generalized Hematopoietic Hypoplasia Scid With Leukopenia RDYS
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Maxillary Sinus Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Maxillofacial Sinus
Maxillary Sinus Cancer	Malignant Neoplasm Of Antrum Malignant Tumor Of The Maxillary Sinus Maxillary Sinus Carcinoma Cancer Of Maxillary Sinus Maxillary Sinus Neoplasms
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
T Cell Deficiency	T Cell Immunodeficiency T Lymphocyte Deficiency T Lymphocyte Immunodeficiency T-Lymphocyte Deficiency
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Bare Lymphocyte Syndrome, Type Ii	Mhc Class Ii Deficiency Bare Lymphocyte Syndrome Major Histocompatibility Complex Class Ii Deficiency Bare Lymphocyte Syndrome 2 Bare Lymphocyte Syndrome Type 2 Severe Combined Immunodeficiency, Hla Class Ii-Negative Bare Lymphocyte Syndrome, Type Ii, Complementation Group C Bare Lymphocyte Syndrome, Type Ii, Complementation Group D Bare Lymphocyte Syndrome Type Ii Scid, Hla Class Ii-Negative Bare Lymphocyte Syndrome, Type Ii, Complementation Group A Bare Lymphocyte Syndrome, Type Ii, Complementation Group B Scid Due To Absent Class Ii Hla Antigens Hla Class 1 Deficiency Scid, Hla Class 2-Negative Bls Type Ii Bare Lymphocyte Syndrome Type 2, Complementation Group A Bare Lymphocyte Syndrome Type 2, Complementation Group E Severe Combined Immunodeficiency Bls, Type Ii Bls Bare Lymphocyte Syndrome, Type Ii, Complementation Group E Blsii Bls Type 1 Bls 2 Scid Due To Absence Of Class Ii Hla Antigens Severe Combined Immunodeficiency Due To Absent Class Ii Human Leukocyte Antigens Immunodeficiency By Defective Expression Of Mhc Class Ii BLS2 Bare Lymphocyte Syndrome Type Ii Complementation Group A Bare Lymphocyte Syndrome Type Ii Complementation Group B Bare Lymphocyte Syndrome Type Ii Complementation Group C Bare Lymphocyte Syndrome Type Ii Complementation Group D Bare Lymphocyte Syndrome Type Ii Complementation Group E Bls Ii Hereditary Mhc Class Ii Deficiency Hla Class Ii Deficient Combined Immunodeficiency Mhc-Ii Deficiency Scid Hla Class Ii-Negative Severe Combined Immunodeficiency Hla Class Ii-Negative Bl-2 Immunodeficiency By Defective Expression Of Hla Class 2 Hla Class 2-Negative Severe Combined Immunodeficiency
Hematologic Cancer	Hematologic Neoplasm Hematologic Neoplasms Hematologic Malignancies Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Omenn Syndrome	Histiocytic Medullary Reticulosis Severe Combined Immunodeficiency With Hypereosinophilia Combined Immunodeficiency With Hypereosinophilia Reticuloendotheliosis, Familial, With Eosinophilia Reticuloendotheliosis Familial With Eosinophilia Familial Reticuloendotheliosis Omenn'S Syndrome OS Malignant Histiocytosis
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (5)

Referencia número	Nombre del producto	Pureza	Rare Diseases
HY-16210	Forodesine	99.62%	Yes
HY-16209	Forodesine hydrochloride	99.86%	Yes
HY-W011727A	Pyridoxal 5'-phosphate monohydrate	98.0%	Unkown
HY-W011727	Pyridoxal 5'-phosphate hydrate	99.76%	Unkown
HY-W011727AR	Pyridoxal 5'-phosphate monohydrate (Standard)	/	Unkown

Clinical Phase

Bioactive Molecules (3)

Referencia número	Nombre del producto	Efecto	Pureza	Phase
HY-19480	Ulodesine	Inhibitor	99.32%	Phase 2
HY-106934	Peldesine	Inhibitor	/	Phase 1
HY-118047	CI 972 anhydrous	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (109)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-20336	Mc-Val-Cit-PABC-PNP		98.75%	Unkown
HY-41189	Fmoc-Val-Cit-PAB-PNP		99.60%	Unkown
HY-128933	AMP-PNP tetralithium	Inhibitor	99.92%	Unkown
HY-130777A	AMP-PNP lithium hydrate		99.98%	Unkown
HY-136329	β-D-glucuronide-pNP-carbonate		99.60%	Unkown
HY-136136	Fmoc-Val-Ala-PAB-PNP		99.28%	Unkown
HY-141142	Boc-Val-Cit-PAB-PNP		99.55%	Unkown
HY-W008638	2'-Deoxyinosine		99.91%	Unkown
HY-135975	MC-Val-Ala-PAB-PNP		99.31%	Unkown
HY-130937	DBCO-Val-Cit-PABC-PNP		97.74%	Unkown
HY-140145	Mal-PEG4-Val-Cit-PAB-PNP		98.48%	Unkown
HY-137827	4-Nitrophenyl β-D-Cellobioside	Substrate	99.94%	Unkown
HY-140150	Azido-PEG3-Val-Cit-PAB-PNP		99.21%	Unkown
HY-147164	MC-Gly-Gly-Phe-Gly-PAB-PNP		99.22%	Unkown
HY-112835	Ethylidene-4-nitrophenyl-a-D-Maltoheptaoside	Substrate	98.03%	Unkown
HY-P2724	Purine nucleoside phosphorylase, Microorganism		/	Unkown
HY-W011727S	Pyridoxal Phosphate-d3		98.01%	Unkown
HY-148425	Mal-amide-PEG8-Val-Ala-PAB-PNP		95.73%	Unkown
HY-W039442	2′-Deoxy-2′-fluoroadenosine		99.71%	Unkown
HY-139362	Enpp-1-IN-2	Inhibitor	99.51%	Unkown
HY-W015996	4-Nitrophenyl-N-acetyl-α-D-galactosaminide		99.92%	Unkown
HY-130932	Boc-Val-Ala-PAB-PNP		98.62%	Unkown
HY-136154	Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP		96.67%	Unkown
HY-148461	Mal-VC-PAB-PNP		99.21%	Unkown
HY-106934A	Peldesine dihydrochloride	Inhibitor	99.28%	Yes
HY-134420	p-Nitrophenyl α-L-fucoside	Substrate	98.80%	Unkown
HY-121106	9-Deazaguanine		99.01%	Unkown
HY-W190913	DBCO-PEG4-Val-Cit-PAB-PNP		98.28%	Unkown
HY-131156	Mal-PEG2-Val-Cit-PABA-PNP		95.68%	Unkown
HY-114430	Fmoc-Phe-Lys(Boc)-PAB-PNP		98.67%	Unkown
HY-136100A	TCO-PEG1-Val-Cit-PABC-PNP TFA		99.69%	Unkown
HY-W039911	4-Nitrophenyl α-D-galactopyranoside		98.70%	Unkown
HY-160916	N3-PEG8-Oxydiacetamide-Phe-Lys(MMT)-PAB-PNP		/	Unkown
HY-134354A	pNP-ADPr disodium		98.08%	Unkown
HY-140147	Mal-amido-PEG2-Val-Cit-PAB-PNP		98.40%	Unkown
HY-147021	MC-Val-D-Cit-PAB-PNP		98.08%	Unkown
HY-W591374	DBCO-PEG4-Val-Ala-PAB-PNP		95.03%	Unkown
HY-151726	Azido-PEG(4)-Val-Cit-PAB-PNP		98.05%	Unkown
HY-W008638R	2'-Deoxyinosine (Standard)		99.77%	Unkown
HY-129350	Fmoc-Phe-Lys(Trt)-PAB-PNP		98.0%	Unkown
HY-137878	2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid		/	Unkown
HY-140144	Mal-PEG1-Val-Cit-PAB-PNP		98.41%	Unkown
HY-173161	Mc-d-Val-d-Cit-PAB-PNP		98.80%	Unkown
HY-172291	Mal-amide-PEG8-Val-Cit-PAB-PNP		98.05%	Unkown
HY-W591339	Mal-PEG8-Val-Cit-PAB-PNP		96.28%	Unkown
HY-W800619	NH2-PEG4-Val-Cit-PAB-OH		99.35%	Unkown
HY-129352	Cbz-Phe-(Alloc)Lys-PAB-PNP		/	Unkown
HY-106421	BCX-5		/	Unkown
HY-129351	Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP		/	Unkown
HY-129353	Boc-Phe-(Alloc)Lys-PAB-PNP		/	Unkown
HY-129361	Fmoc-Ala-Ala-Asn-PABC-PNP		/	Unkown
HY-134354	pNP-ADPr		/	Unkown
HY-136100	TCO-PEG1-Val-Cit-PABC-PNP		/	Unkown
HY-136105	Azido-PEG1-Val-Cit-PABC-PNP		/	Unkown
HY-136108	Fmoc-Gly3-Val-Cit-PAB-PNP		/	Unkown
HY-139247	pNPS-DHA		/	Unkown
HY-139856	Mal-Ala-Ala-PAB-PNP		/	Unkown
HY-141145	OPSS-Val-Cit-PAB-PNP		/	Unkown
HY-144628	Fmoc-Asn-Pro-Val-PABC-PNP		99.34%	Unkown
HY-147021A	MC-D-Val-Cit-PAB-PNP		/	Unkown
HY-148031	MC-Ala-Ala-Asn-PAB-PNP		/	Unkown
HY-148399	Mal-VC-PAB-PNP-CDN-A		/	Unkown
HY-153216	MC-Phe-Lys(MMT)-PAB-PNP		/	Unkown
HY-153486	N3-VC-PAB-PNP		97.35%	Unkown
HY-158199	BCN-HS-PEG2-bis(PNP)		/	Unkown
HY-160703	DMBA-SIL-PNP		/	Unkown
HY-164340	Boc-NH-PAB(triacetyl-β-D-glucopyranuronate)-PNP		/	Unkown
HY-176930	N-Fmoc-EvcPAB-PNP		/	Unkown
HY-20336G	Mc-Val-Cit-PABC-PNP (GMP)		/	Unkown
HY-P11295	Fmoc-GGFG-PAB-PNP		98.29%	Unkown
HY-P2724A	Purine nucleoside phosphorylase, Bacillus sp.		/	Unkown
HY-RS10789	PNP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11042	PPY Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W145534	GlcNAcβ(1-3)GalNAc-α-pNP		/	Unkown
HY-W145540	Galβ(1-3)[Neu5Acα(2-6)]GalNAc-α-pNP		/	Unkown
HY-W145553	GalNAcβ(1-3)GlcNAc-β-pNP		/	Unkown
HY-W145556	Galβ(1-3)GlcNAcβ(1-3)Galβ(1-4)Glc-β-pNP		/	Unkown
HY-W145607	Galβ(1-3)GalNAc-β-pNP		/	Unkown
HY-W145622	Galβ(1-3)[Neu5Acα(2-6)]GlcNAc-β-pNP		/	Unkown
HY-W145631	GalNAcβ(1-4)GlcNAc-β-pNP		/	Unkown
HY-W357155	Gal1-β-3GlcNAc-β-PNP		/	Unkown
HY-W698379	Gal1-b-4GlcNAc-α-PNP		/	Unkown
HY-W698411	GlcNAc1-β-6GalNAc-α-PNP		/	Unkown
HY-W699180	Fuc1-α-2Gal1-β-3GlcNAc-β-PNP		/	Unkown
HY-W750387	Immucillin-G		/	Unkown
HY-W800847	Mal-Amide-PEG4-Val-Cit-PAB-PNP		/	Unkown
HY-137828	4-Nitrophenyl N,N′-diacetyl-β-D-chitobioside		/	Unkown
HY-141153	Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB-PNP		/	Unkown
HY-151699	6-Azidohexanoyl-Val-Cit-PAB-PNP		/	Unkown
HY-151740	4-Pentynoyl-Val-Ala-PAB-PNP		/	Unkown
HY-160790	β-Glu-PNP		/	Unkown
HY-19480B	Ulodesine succinate	Inhibitor	/	Unkown
HY-20560	(Ac)Phe-Lys(Alloc)-PABC-PNP		/	Unkown
HY-RS16725	Pnp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23161	Pnp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W395122	Mal-PEG1-PNP-carbonate		/	Unkown
HY-W591286	Alkyne-Val-Cit-PAB-PNP		/	Unkown
HY-W591336	Alloc-Val-Ala-PAB-PNP		/	Unkown
HY-W591439	Fmoc-Lys(Boc)-PAB-PNP		/	Unkown
HY-W591440	Fmoc-Cit-PAB-PNP		/	Unkown
HY-W591441	Fmoc-Ala-PAB-PNP		/	Unkown
HY-W800617	NH2-PEG1-Val-Cit-PAB-OH		/	Unkown
HY-W800618	NH2-PEG3-Val-Cit-PAB-OH		/	Unkown
HY-W800620	NH2-PEG6-Val-Cit-PAB-OH		/	Unkown
HY-W800621	Fmoc-PEG2-Val-Cit-PAB-OH		/	Unkown
HY-W800622	Fmoc-PEG4-Val-Cit-PAB-OH		/	Unkown
HY-W800623	Fmoc-PEG6-Val-Cit-PAB-OH		/	Unkown
HY-W800624	Boc-PEG2-Val-Cit-PAB-OH		/	Unkown
HY-W800625	Boc-PEG4-Val-Cit-PAB-OH		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PNP	RGD	RGD:1597189
Canis familiaris	PNP	VGNC	VGNC:44751
Felis catus	PNP	VGNC	VGNC:80883
Others	PNP	NCBI