Cat. No.: HY-N7926

Pentadecane

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Pentadecane is an orally active natural plant volatile alkane with anti-inflammatory, analgesic, antipyretic and anti-leishmanial activities. Pentadecane presents IC₅₀ values of 65.3 μM, 60.5 μM and 194.8 μM against Leishmania infantum promastigotes, amastigotes and intracellular amastigotes, respectively. Pentadecane downregulates the mRNA expression of TNF-α and IL-12 and inhibits the release of inflammatory mediators. Pentadecane arrests the cell cycle of Leishmania infantum and induces apoptosis. Pentadecane can be applied to the research of inflammation and leishmaniasis.

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Pureté: 98.88%
CAS No.: 629-62-9
Formule: C₁₅H₃₂
Masse moléculaire:212.41

Stockage:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

Pentadecane Chemical Structure

CAS No.: 629-62-9

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]^[3]

IL-12

TNF-α

Leishmania

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In Vitro

Pentadecane (10-60 µg/mL; overnight) does not inhibit the growth of Staphylococcus aureus, Bacillus subtilis, Escherichia coli, or Pseudomonas aeruginosa^[1].
Pentadecane (60 µg/mL; 8 h) temporarily inhibits the growth of Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa over an 8-hour period, but does not prevent long-term bacterial growth^[1].
Pentadecane (10-70 µg/mL; 48 h pre-incubation, followed by 48 h LPS/IFN-γ stimulation) significantly downregulates TNF-α and IL-12 mRNA expression in LPS/IFN-γ-induced M1 phenotype U937 macrophages, with the most potent TNF-α inhibition seen at 10 µg/mL in hexane^[1].
Pentadecane (50-300 μM; 48 h) inhibits the viability of Leishmania infantum promastigotes (IC₅₀ = 65.3 μM) and axenic amastigotes (IC₅₀ = 60.5 μM) in a dose-dependent manner^[3].
Pentadecane (65.3-300 μM; 48 h) induces apoptotic-like morphological changes (loss of cell volume, nuclear condensation) in Leishmania infantum promastigotes^[3].
Pentadecane (65.3 μM; 24 h) induces cell cycle arrest in Leishmania infantum promastigotes, increasing the proportion of cells in the sub-G0/G1 phase and eliminating cells in the G2/M phase^[3].
Pentadecane (50-300 μM; 48 h) causes negligible cytotoxicity in DH82 dog macrophage cells, U937 human histiocytic lymphoma cells, and normal CPE primary epithelial cells^[3].
Pentadecane (300 μM; 48 h) inhibits the growth of Leishmania infantum intracellular amastigotes in U937-derived macrophages, reducing infection by 77% at 300 μM and exhibiting an IC₅₀ of 194.8 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

LPS/IFN-γ-induced M1 phenotype U937 human monocytic macrophages
Concentration:

10, 70 µg/mL
Incubation Time:

48 h pre-incubation, followed by 48 h LPS/IFN-γ stimulation
Result:

Showed the most significant downregulation of TNF-α mRNA expression at 10 µg/mL (hexane) compared to the LPS-treated M1 control.
Significantly downregulated IL-12 mRNA expression at all tested concentrations compared to the LPS-treated M1 control.
Showed no significant difference in IL-12 mRNA expression from the 10% hexane control group at 70 µg/mL (hexane).

Cell Viability Assay^[1]

Cell Line:

human dermal fibroblast (HDF) cells
Concentration:

10, 20, 30, 40, 50, 60, 70 µg/mL
Incubation Time:

48 h
Result:

Resulted in average cell viability between 58% and 103%, with viability averagely higher than cells treated with palmitic acid.

Cell Viability Assay^[3]

Cell Line:

DH82 dog macrophage cells, U937 human histiocytic lymphoma cells, primary epidermal cells of CPE
Concentration:

50 μM, 100 μM, 150 μM, 200 μM, 250 μM, 300 μM
Incubation Time:

48 h
Result:

Maintained DH82 cell viability between ~78% and ~94%.
Maintained CPE cell viability between ~84% and ~122%.
Maintained U937 cell viability between ~86% and ~137%.
Resulted in all tested cell lines showing viability higher than 60% across all concentrations, indicating negligible cytotoxicity.

In Vivo

Pentadecane (1000 mg/kg; p.o.; daily; 14 days) shows no apparent acute toxicity in Sprague-Dawley rats at an oral dose of 1000 mg/kg daily for 14 days^[2].
Pentadecane (5, 10 mg/kg; p.o.; single dose) exhibits significant dose-dependent analgesic activity in the acetic acid-induced writhing model in Sprague-Dawley rats^[2].
Pentadecane (5, 10 mg/kg; p.o.; single dose) exhibits significant analgesic activity targeting inflammatory nociception in the formalin-induced paw licking model in Sprague-Dawley rats^[2].
Pentadecane (5, 10 mg/kg; p.o.; single dose) exhibits significant anti-inflammatory activity in the carrageenan-induced paw edema model in Sprague-Dawley rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 629-62-9
Appearance Liquid (Density: 0.769 g/cm³)
Masse moléculaire 212.41
Formule C₁₅H₃₂
Color Colorless to off-white
SMILES

CCCCCCCCCCCCCCC
Structure Classification
- Others
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (470.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.7079 mL

23.5394 mL

47.0788 mL

5 mM

0.9416 mL

4.7079 mL

9.4158 mL

10 mM

0.4708 mL

2.3539 mL

4.7079 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (11.77 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (11.77 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (11.77 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
SDS (623 KB)
- English - EN (623 KB)
- Français - FR (623 KB)
- Deutsch - DE (623 KB)
- Norwegian - NO (623 KB)
- Español - ES (623 KB)
- Swedish - SV (623 KB)
- Italian - IT (623 KB)
- Korean - KR (623 KB)
- Portuguese - PT (623 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Chuah XQ. Eicosane, pentadecane and palmitic acid: The effects in in vitro wound healing studies. Asian Pac J Trop Biomed. 2018 Oct;8(10):490-499.

[2]. Patrick Nwabueze Okechukwu. Evaluation of anti-inflammatory, analgesic, antipyretic effect of eicosane, pentadecane, octacosane, and heneicosane. Asian Journal of Pharmaceutical and Clinical Research. 2020 May;13(4).

[3]. Bruno F, et al. Cytotoxic Screening and In Vitro Evaluation of Pentadecane Against Leishmania infantum Promastigotes and Amastigotes. J Parasitol. 2015;101(6):701-705. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.7079 mL	23.5394 mL	47.0788 mL	117.6969 mL
	5 mM	0.9416 mL	4.7079 mL	9.4158 mL	23.5394 mL
	10 mM	0.4708 mL	2.3539 mL	4.7079 mL	11.7697 mL
	15 mM	0.3139 mL	1.5693 mL	3.1386 mL	7.8465 mL
	20 mM	0.2354 mL	1.1770 mL	2.3539 mL	5.8848 mL
	25 mM	0.1883 mL	0.9416 mL	1.8832 mL	4.7079 mL
	30 mM	0.1569 mL	0.7846 mL	1.5693 mL	3.9232 mL
	40 mM	0.1177 mL	0.5885 mL	1.1770 mL	2.9424 mL
	50 mM	0.0942 mL	0.4708 mL	0.9416 mL	2.3539 mL
	60 mM	0.0785 mL	0.3923 mL	0.7846 mL	1.9616 mL
	80 mM	0.0588 mL	0.2942 mL	0.5885 mL	1.4712 mL
	100 mM	0.0471 mL	0.2354 mL	0.4708 mL	1.1770 mL

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Pentadecane

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Voir tous les produits spécifiques à Isoform TNF Receptor

Voir tous les produits spécifiques à Isoform Parasite

Voir tous les produits spécifiques à Isoform Interleukin Related

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Pentadecane Related Classifications

HY-N7926 Related Classifications