(5R)-5-Hydroxytriptolide
(Synonyms: PG 701; LLDT-8; 5α-Hydroxytriptolide)
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Based on 1 Customer Validation
(5R)-5-Hydroxytriptolide is an extracted compound from Tripterygium, and shows lower cell cytotoxicity and higher immunosuppressive activity. (5R)-5-Hydroxytriptolide can be used for study of rheumatoid arthritis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.67%
- No. CAS: 583028-68-6
- Fòrmula: C20H24O7
- Peso molecular:376.40
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
Descripciòn
(5R)-5-Hydroxytriptolide is an extracted compound from Tripterygium, and shows lower cell cytotoxicity and higher immunosuppressive activity. (5R)-5-Hydroxytriptolide can be used for study of rheumatoid arthritis[1].
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.04 nM
Compound: 7; LLDT-8
|
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by MTT assay
|
[PMID: 31121546] |
| BGC-823 | IC50 |
1.5 μM
Compound: 7; LLDT-8
|
Cytotoxicity against human BGC823 cells assessed as decrease in cell viability by MTT assay
Cytotoxicity against human BGC823 cells assessed as decrease in cell viability by MTT assay
|
[PMID: 31121546] |
| HeLa | IC50 |
0.34 μM
Compound: 7; LLDT-8
|
Cytotoxicity against human HeLa cells assessed as decrease in cell viability by MTT assay
Cytotoxicity against human HeLa cells assessed as decrease in cell viability by MTT assay
|
[PMID: 31121546] |
| HL-60 | IC50 |
0.04 nM
Compound: 7; LLDT-8
|
Cytotoxicity against human HL60 cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells assessed as decrease in cell viability after 72 hrs by MTT assay
|
[PMID: 31121546] |
| HL-60 | IC50 |
0.47 μM
Compound: 7; LLDT-8
|
Cytotoxicity against human HL60 cells assessed as decrease in cell viability by MTT assay
Cytotoxicity against human HL60 cells assessed as decrease in cell viability by MTT assay
|
[PMID: 31121546] |
| KB | IC50 |
0.3 μM
Compound: 7; LLDT-8
|
Cytotoxicity against human KB cells assessed as decrease in cell viability by MTT assay
Cytotoxicity against human KB cells assessed as decrease in cell viability by MTT assay
|
[PMID: 31121546] |
| MCF7 | IC50 |
0.04 nM
Compound: 7; LLDT-8
|
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by MTT assay
|
[PMID: 31121546] |
| MCF7 | IC50 |
1.05 μM
Compound: 7; LLDT-8
|
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability by MTT assay
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability by MTT assay
|
[PMID: 31121546] |
| MKN-28 | IC50 |
0.04 nM
Compound: 7; LLDT-8
|
Cytotoxicity against human MKN28 cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MKN28 cells assessed as decrease in cell viability after 72 hrs by MTT assay
|
[PMID: 31121546] |
| P388 | IC50 |
0.04 nM
Compound: 7; LLDT-8
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Cytotoxicity against mouse P388 cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against mouse P388 cells assessed as decrease in cell viability after 72 hrs by MTT assay
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[PMID: 31121546] |
| PC-3 | IC50 |
0.275 μM
Compound: 4
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Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation by sulforhodamine B assay
Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation by sulforhodamine B assay
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[PMID: 25467158] |
| U-251 | IC50 |
0.488 μM
Compound: 4
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Cytotoxicity against human U251 cells assessed as inhibition of cell proliferation by sulforhodamine B assay
Cytotoxicity against human U251 cells assessed as inhibition of cell proliferation by sulforhodamine B assay
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[PMID: 25467158] |
Chemical Information
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No. CAS 583028-68-6
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Appearance Solid
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Peso molecular 376.40
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Fòrmula C20H24O7
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Color White to off-white
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SMILES
CC([C@@]12[C@H]([C@H]3[C@]4([C@@]5(C)CCC6=C(COC6=O)[C@]5(O)C[C@H]7[C@@]4(O7)[C@@H]2O)O3)O1)C
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Synonyms
PG 701; LLDT-8; 5α-Hydroxytriptolide
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
Select Batch:
Pureza:
99.98%
Assay:
99.98%
ee.:
99.98%
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Ficha de datos (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
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Calculadora de dilución
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(5R)-5-Hydroxytriptolide Related Classifications
HY-107101 Related Classifications
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