Referencia número: HY-N0532

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Morroniside

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Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.

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Pureza: 99.94%
No. CAS: 25406-64-8
Fòrmula: C₁₇H₂₆O₁₁
Peso molecular:406.38

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Morroniside Chemical Structure

No. CAS: 25406-64-8

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Solvente y solubilidad
- In Vitro
- In Vivo
Protocolo
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.

IC₅₀ & Target^[1]

MMP2

MMP9

Ver todos los productos específicos de isoformas MMP :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	>50 μM Compound: 17	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 23002924]

In Vivo

Morroniside reduces the expression of MMP2 and MMP9 in an I/R injury model. Treatment with Morroniside significantly reduces I/R associated neuron apoptosis in a dose dependent manner. The results demonstrate that active caspase 3 and Bax are significantly upregulated in the model group compared with the control group, while Bcl 2 is significantly downregulated. The expression of active caspase 3 and Bax is significantly downregulated by Morroniside treatment in a dose dependent manner, while the expression of Bcl 2 is significantly upregulated^[1]. Morroniside has an ameliorative effect on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 25406-64-8
Appearance Solid
Peso molecular 406.38
Fòrmula C₁₇H₂₆O₁₁
Color White to off-white
SMILES

O[C@H]([C@@H](O)[C@@H]1O)[C@](O[C@@H]1CO)([H])O[C@H]2[C@@]([C@@H]3C)([H])[C@@](C[C@H](O)O3)([H])C(C(OC)=O)=CO2
Structure Classification
- Terpenoids
- Iridoids
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (246.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4608 mL

12.3038 mL

24.6075 mL

5 mM

0.4922 mL

2.4608 mL

4.9215 mL

10 mM

0.2461 mL

1.2304 mL

2.4608 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (5.12 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (5.12 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (5.12 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (246.08 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Protocolo

Animal Administration^[1]

Rats^[1]
A total of 50 adult male Sprague Dawley rats (age, 7 8 weeks; weight, 260 280 g) are used. Rats are randomly assigned into five groups (n=10 in each). Rats in the control group undergo sham surgery. All other rats undergo suture occluded surgery, with a 0.26 mm nylon monofilament inserted through the right common carotid artery and are divided into groups as follows: The cerebral I/R injury model group (model), no treatment; low dose group, 30 mg/kg/day Morroniside by gavage; moderate dose group, 90 mg/kg/day Morroniside by gavage; high dose group, 270 mg/kg/day Morroniside by gavage. Rats in the control and model groups receive an equal volume of normal saline^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (282 KB)

SDS (393 KB)

English - EN (393 KB)

Français - FR (393 KB)

Deutsch - DE (393 KB)

Norwegian - NO (393 KB)

Español - ES (393 KB)

Swedish - SV (393 KB)

Italian - IT (393 KB)

Korean - KR (393 KB)

Portuguese - PT (393 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Zeng G, et al. Morroniside protects against cerebral ischemia/reperfusion injury by inhibiting neuron apoptosis and MMP2/9 expression. Exp Ther Med. 2018 Sep;16(3):2229-2234. [Content Brief]

[2]. Park CH, et al. Evaluation of morroniside, iridoid glycoside from Corni Fructus, on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice. Biol Pharm Bull. 2011;34(10):1559-65. [Content Brief]

[3]. Huan Yu, et al. Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-κB signaling. J Ethnopharmacol. 2021 Feb 10;266:113447. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg

DMSO 1 mM 2.4608 mL 12.3038 mL 24.6075 mL 61.5188 mL

5 mM 0.4922 mL 2.4608 mL 4.9215 mL 12.3038 mL

10 mM 0.2461 mL 1.2304 mL 2.4608 mL 6.1519 mL

15 mM 0.1641 mL 0.8203 mL 1.6405 mL 4.1013 mL

20 mM 0.1230 mL 0.6152 mL 1.2304 mL 3.0759 mL

25 mM 0.0984 mL 0.4922 mL 0.9843 mL 2.4608 mL

30 mM 0.0820 mL 0.4101 mL 0.8203 mL 2.0506 mL

40 mM 0.0615 mL 0.3076 mL 0.6152 mL 1.5380 mL

50 mM 0.0492 mL 0.2461 mL 0.4922 mL 1.2304 mL

60 mM 0.0410 mL 0.2051 mL 0.4101 mL 1.0253 mL

80 mM 0.0308 mL 0.1538 mL 0.3076 mL 0.7690 mL

100 mM 0.0246 mL 0.1230 mL 0.2461 mL 0.6152 mL

Morroniside Related Classifications

HY-N0532 Related Classifications

Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis

MMP Pyroptosis Apoptosis

Disease Areas

Cancer Neurological, Eye or Ear Disease Inflammation or Immune System Disease Metabolic or Endocrine Disease Respiratory Disease Digestive System Disease Musculoskeletal and Skin Disease

Pulmonary Disease Autoimmune Disease Arthritis Pancreatic Cancer Digestive System Cancer Pain Digestive System Inflammation Glucose Metabolism

Lung Fibrosis Rheumatoid Arthritis

Productos Naturales

Plants Terpenoids

Cornaceae Iridoids

Cornus officinalis Sieb. et Zucc.

Saccharides

Glycosides

Neurological Disease Metabolic Disease

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Keywords

Morroniside
25406-64-8
MMP
Pyroptosis
Apoptosis
Inhibitor
inhibitor
inhibit

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Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.4608 mL	12.3038 mL	24.6075 mL	61.5188 mL
5 mM	0.4922 mL	2.4608 mL	4.9215 mL	12.3038 mL
10 mM	0.2461 mL	1.2304 mL	2.4608 mL	6.1519 mL
15 mM	0.1641 mL	0.8203 mL	1.6405 mL	4.1013 mL
20 mM	0.1230 mL	0.6152 mL	1.2304 mL	3.0759 mL
25 mM	0.0984 mL	0.4922 mL	0.9843 mL	2.4608 mL
30 mM	0.0820 mL	0.4101 mL	0.8203 mL	2.0506 mL
40 mM	0.0615 mL	0.3076 mL	0.6152 mL	1.5380 mL
50 mM	0.0492 mL	0.2461 mL	0.4922 mL	1.2304 mL
60 mM	0.0410 mL	0.2051 mL	0.4101 mL	1.0253 mL
80 mM	0.0308 mL	0.1538 mL	0.3076 mL	0.7690 mL
100 mM	0.0246 mL	0.1230 mL	0.2461 mL	0.6152 mL

Morroniside

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Morroniside

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Ver todos los productos específicos de isoformas MMP

Actividad biológica

Chemical Information

Solvente y solubilidad

Protocolo

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

Morroniside Related Classifications

HY-N0532 Related Classifications