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Referencia número: HY-149348

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DiPT-4

DiPT-4 is a dual TOP1/PARP1 inhibitor that induces massive DNA double-strand breaks (DSBs), cell cycle arrest, and apoptosis in cancer cells. DiPT-4 has the potential to overcome cancer drug resistance.

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No. CAS: 3052259-89-6
Fòrmula: C₃₂H₂₂FN₅O₄S
Peso molecular:591.61

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

DiPT-4 Chemical Structure

No. CAS: 3052259-89-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
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Calculators
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Bioz

Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Topoisomerase :

Ver todos los productos específicos de isoformas PARP :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	4 μM Compound: DiPT-4	Cytotoxicity against human HCT-116 cells incubated for 72 hrs by MTT assay Cytotoxicity against human HCT-116 cells incubated for 72 hrs by MTT assay	[PMID: 37406384]
MIA PaCa-2	IC₅₀	4.5 μM Compound: DiPT-4	Cytotoxicity against human MIA PaCa-2 cells incubated for 72 hrs by MTT assay Cytotoxicity against human MIA PaCa-2 cells incubated for 72 hrs by MTT assay	[PMID: 37406384]
PANC-1	IC₅₀	4 μM Compound: DiPT-4	Cytotoxicity against human PANC-1 cells incubated for 72 hrs by MTT assay Cytotoxicity against human PANC-1 cells incubated for 72 hrs by MTT assay	[PMID: 37406384]

Chemical Information

No. CAS 3052259-89-6
Peso molecular 591.61
Fòrmula C₃₂H₂₂FN₅O₄S
SMILES

O=C1N(CC2=NN=C(SCCN3C(C4=CC=CC5=CC=CC(C3=O)=C45)=O)O2)N=C(CC6=CC=C(F)C=C6)C7=C1C=CC=C7
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Guha Majumdar A, et al. Design, synthesis and development of a dual inhibitor of Topoisomerase 1 and poly (ADP-ribose) polymerase 1 for efficient killing of cancer cells. Eur J Med Chem. 2023 Oct 5;258:115598. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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DiPT-4

Ver todos los productos específicos de isoformas Topoisomerase

Ver todos los productos específicos de isoformas PARP

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

DiPT-4 Related Classifications

HY-149348 Related Classifications