Metronidazole solution
Based on 82 publication(s) in Google Scholar
Metronidazole solution is mainly composed of Metronidazole (HY-B0318). Metronidazole is an orally active nitroimidazole antibiotic. Metronidazole can cross blood brain barrier. Metronidazole can be used for the research of anaerobic infections.
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- No. CAS: 443-48-1
- Fòrmula: C6H9N3O3
- Peso molecular:171.15
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Metronidazole solution
More- Cancer Cell. 2025 Sep 25:S1535-6108(25)00394-0. [Abstract]
- Science. 2026 Mar 19;391(6791):eadu7686. [Abstract]
- Cell Metab. 2025 Jan 7;37(1):87-103.e10. [Abstract]
- Cell Metab. 2023 Nov 7;35(11):1961-1975.e6. [Abstract]
- Immunity. 2026 Mar 10;59(3):598-617.e11. [Abstract]
- Immunity. 2026 Mar 27:S1074-7613(26)00086-5. [Abstract]
- Gut. 2025 May 7;74(6):935-947. [Abstract]
- Cell Host Microbe. 2026 Jul 8;34(7):1350-1366.e8. [Abstract]
- Cancer Res. 2026 May 15. [Abstract]
- J Adv Res. 2024 Oct 21:S2090-1232(24)00472-7. [Abstract]
- Gut Microbes. 2026 Dec 31;18(1):2620125. [Abstract]
- Gut Microbes. 2025 Dec;17(1):2545434. [Abstract]
- Gut Microbes. 2023 Dec;15(2):2249143. [Abstract]
- Gut Microbes. 2023 Dec;15(2):2282790. [Abstract]
- Microbiome. 2020 Aug 20;8(1):120. [Abstract]
- J Clin Invest. 2026 Jul 28;136(18):e199913.
- Adv Sci (Weinh). 2025 May;12(20):e2409837. [Abstract]
- Cell Rep Med. 2025 Oct 21;6(10):102410. [Abstract]
- Water Res. 2023 Jul 15:240:120110. [Abstract]
- Pharmacol Res. 2024 Jul:205:107229. [Abstract]
- Pharmacol Res. 2024 Jun:204:107214. [Abstract]
- Cell Death Dis. 2021 Jun 7;12(6):582. [Abstract]
- J Immunother Cancer. 2026 Jul 21;14(7):e015159.
- J Exp Med. 2026 Mar 2;223(3):e20241287. [Abstract]
- J Neuroinflammation. 2026 May 26.
- J Neuroinflammation. 2025 Nov 4;22(1):259. [Abstract]
- NPJ Biofilms Microbiomes. 2026 Aug 24.
- NPJ Biofilms Microbiomes. 2024 Oct 28;10(1):111. [Abstract]
- Phytomedicine. 2026 Sep 23:162:158817.
- J Pharm Anal. 2023 Oct;13(10):1153-1167. [Abstract]
- Ultrason Sonochem. 2026 Sep:132:107985.
- Sci China Life Sci. 2026 Apr;69(4):1271-1283. [Abstract]
- Food Chem X. 2026 Feb 8:34:103646. [Abstract]
- Food Res Int. 2026 Jul 31:236:119200. [Abstract]
- Int J Biol Macromol. 2024 Nov;281(Pt 4):135835. [Abstract]
- Neural Regen Res. 2024 Sep 1;19(9):2081-2088. [Abstract]
- Free Radic Biol Med. 2025 Oct:238:640-652. [Abstract]
- Clin Transl Med. 2026 Aug;16(8):e70754.
- Clin Transl Med. 2024 Oct;14(10):e70035. [Abstract]
- Cancer Immunol Res. 2022 Dec 2;10(12):1542-1558. [Abstract]
- Am J Chin Med. 2024;52(5):1527-1554. [Abstract]
- Aging Cell. 2026 May;25(5):e70539. [Abstract]
- Cell Rep. 2025 Feb 28;44(3):115356. [Abstract]
- Cell Rep. 2020 Dec 1;33(9):108438. [Abstract]
- Neurotherapeutics. 2023 Sep;20(5):1405-1426. [Abstract]
- Emerg Microbes Infect. 2022 Dec;11(1):815-828. [Abstract]
- J Ethnopharmacol. 2026 Mar 1:358:120992. [Abstract]
- J Agric Food Chem. 2024 Apr 10. [Abstract]
- CNS Neurosci Ther. 2026 May;32(5):e70933. [Abstract]
- Ecotoxicol Environ Saf. 2025 Nov 15:307:119433. [Abstract]
- CNS Neurosci Ther. 2025 Feb;31(2):e70253. [Abstract]
- Biochem Pharmacol. 2024 Dec;230(Pt 2):116593. [Abstract]
- Life Sci. 2020 Nov 15:261:118473. [Abstract]
- Int Immunopharmacol. 2025 Jun 26:159:114888. [Abstract]
- Front Aging Neurosci. 2022 Jul 28;14:858130. [Abstract]
- Sci Rep. 2025 Jul 2;15(1):22990. [Abstract]
- Exp Neurol. 2025 Mar:385:115142. [Abstract]
- iScience. 2025 Sep 25;28(11):113648. [Abstract]
- iScience. 2025 May 13;28(7):112658. [Abstract]
- iScience. 2025 May 27;28(6):112763. [Abstract]
- iScience. 2023 Oct 7;26(11):108158. [Abstract]
- Aquaculture. 2021, 736248.
- Antimicrob Agents Chemother. 2021 Feb 17;65(3):e01921-20. [Abstract]
- Naunyn Schmiedebergs Arch Pharmacol. 2025 Apr;398(4):3681-3695. [Abstract]
- J Cell Physiol. 2022 Mar;237(3):1845-1856. [Abstract]
- AMB Express. 2026 May 20. [Abstract]
- Carcinogenesis. 2023 Dec 2;44(8-9):682-694. [Abstract]
- Mol Immunol. 2022 Sep:149:94-106. [Abstract]
- Biochem Biophys Res Commun. 2025 Aug 30:776:152161. [Abstract]
- bioRxiv. 2026 Sep 21.
- medRxiv. 2026 Aug 10.
- SSRN. 2026 Aug 7.
- Res Sq. 2026 Mar 11.
- bioRxiv. 2026 Feb 26.
- SSRN. 2026 Jan 7.
- bioRxiv. 2025 Oct 9.
- bioRxiv. 2024 Jul 25.
- Res Sq. 2024 Oct 02.
- bioRxiv. 2024 May 10.
- Research Square Print. 2023 Mar 10.
- Research Square Preprint. 2021 Aug.
- bioRxiv. 2019 Oct.
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Actividad biológica
Descripciòn
Chemical Information
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No. CAS 443-48-1
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Peso molecular 171.15
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Fòrmula C6H9N3O3
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SMILES
OCCN1C([N+]([O-])=O)=CN=C1C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (82)
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Journal Impact Factor
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Most Recent
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Cancer Cell
Ketogenic diet inhibits glioma progression by promoting gut microbiota-derived butyrate production. [Abstract]2025 Sep 25:S1535-6108(25)00394-0. PMID: 41005305 -
Science
Commensal-driven serotonin production modulates in vivo delivery of synthetic and viral vectors. [Abstract]2026 Mar 19;391(6791):eadu7686. PMID: 41855345 -
Cell Metab
Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon. [Abstract]2025 Jan 7;37(1):87-103.e10. PMID: 39366386 -
Cell Metab
High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate. [Abstract]2023 Nov 7;35(11):1961-1975.e6. PMID: 37797623 -
Immunity
2026 Mar 10;59(3):598-617.e11. PMID: 41722568 -
Immunity
NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells. [Abstract]2026 Mar 27:S1074-7613(26)00086-5. PMID: 41903549 -
Gut
Dysbiotic oral microbiota-derived kynurenine, induced by chronic restraint stress, promotes head and neck squamous cell carcinoma by enhancing CD8+ T cell exhaustion. [Abstract]2025 May 7;74(6):935-947. PMID: 39904603 -
Cell Host Microbe
Gut bacteria that produce fatty acid ethanolamides alleviate diarrhea-predominant IBS with insulin resistance. [Abstract]2026 Jul 8;34(7):1350-1366.e8. PMID: 42320473 -
Cancer Res
Distinct Inflammatory Cytotoxic T Lymphocyte Populations Mediate PD-1 Blockade Induced Immune-Related Adverse Events in Multiple Organs. [Abstract]2026 May 15. PMID: 42139517 -
J Adv Res
The gut microbiotas with metabolites regulate the protective role of miR-30a-5p in myocardial infarction. [Abstract]2024 Oct 21:S2090-1232(24)00472-7. PMID: 39442873 -
Gut Microbes
Gut microbial ammonia as a mediator of PFOS neurotoxicity and its remediation by the flavonoid Icaritin. [Abstract]2026 Dec 31;18(1):2620125. PMID: 41629743 -
Gut Microbes
Gut microbiota-mediated betaine regulates skeletal muscle fiber type transition by affecting m6A RNA methylation and Myh7 expression. [Abstract]2025 Dec;17(1):2545434. PMID: 40824213
Metronidazole solution purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2545434. [Abstract]
Western blot analysis of METTL3 and YTHDF2 protein expression from the CON and ABX (Ampicillin (1 g/L), Neomycin (1 g/L), Metronidazole (1 g/L), and vancomycin (0.5 g/L); drinking water from 6 to 12 weeks) mice (n = 3/group).
Metronidazole solution purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2545434. [Abstract]
RT-qPCR analysis of METTL3 and YTHDF2 protein expression from the CON and ABX (Ampicillin (1 g/L), Neomycin (1 g/L), Metronidazole (1 g/L), and vancomycin (0.5 g/L); drinking water from 6 to 12 weeks) mice (n = 3/group).
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Gut Microbes
Microbial metabolite butyrate promotes anti-PD-1 antitumor efficacy by modulating T cell receptor signaling of cytotoxic CD8 T cell. [Abstract]2023 Dec;15(2):2249143. PMID: 37635362
Metronidazole solution purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2023 Dec;15(2):2249143. [Abstract]
Targeted metabolomics analysis of gut microbial metabolites (AA, PA, and BA) in colon contents (feces) and serum from mice with or without ABX treatment (n = 6 per group). ABX: an antibiotic cocktail of 0.5 g/L Vancomycin, 1 g/L Metronidazole,1 g/L Neomycin and 1 g/L Ampicillin
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Gut Microbes
Multi-omics data reveals aberrant gut microbiota-host glycerophospholipid metabolism in association with neuroinflammation in APP/PS1 mice. [Abstract]2023 Dec;15(2):2282790. PMID: 37992400
Metronidazole solution purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2023 Dec;15(2):2282790. [Abstract]
Depletion of CD8+ T cells in ABX-treated B16-F0 tumor-bearing mice dampened the antitumor effect of butyrate combined with anti-PD-1 (Figure 4b–e). Decreased serum IFN-γ and TNF-α production during the depletion of CD8+ T cells was also observed. ABX:an antibiotic cocktail of 0.5 g/L Vancomycin, 1 g/L Metronidazole, 1 g/L Neomycin and 1 g/L Ampicillin.
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Microbiome
The gut microbiota regulates autism-like behavior by mediating vitamin B6 homeostasis in EphB6-deficient mice. [Abstract]2020 Aug 20;8(1):120. PMID: 32819434 -
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Adv Sci (Weinh)
Microbiota-Derived Inosine Suppresses Systemic Autoimmunity via Restriction of B Cell Differentiation and Migration. [Abstract]2025 May;12(20):e2409837. PMID: 40289872 -
Cell Rep Med
Intestinal Lachnospiraceae bacterium-derived propionate inhibits the progression of clear cell renal cell carcinoma. [Abstract]2025 Oct 21;6(10):102410. PMID: 41067230 -
Water Res
Quantifying community-wide antibiotic usage via urban water fingerprinting: Focus on contrasting resource settings in South Africa. [Abstract]2023 Jul 15:240:120110. PMID: 37247434 -
Pharmacol Res
Multi-omics approaches for the understanding of therapeutic mechanism for Huang-Qi-Long-Dan Granule against ischemic stroke. [Abstract]2024 Jul:205:107229. PMID: 38782148 -
Pharmacol Res
Oral microbiota dysbiosis alters chronic restraint stress-induced depression-like behaviors by modulating host metabolism. [Abstract]2024 Jun:204:107214. PMID: 38763328 -
Cell Death Dis
Effects of short-chain fatty acids in inhibiting HDAC and activating p38 MAPK are critical for promoting B10 cell generation and function. [Abstract]2021 Jun 7;12(6):582. PMID: 34099635 -
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J Exp Med
2026 Mar 2;223(3):e20241287. PMID: 41400657
Metronidazole solution purchased from MedChemExpress. Usage Cited in: J Exp Med. 2026 Mar 2;223(3):e20241287. [Abstract]
The number and frequency of MAIT cells in the ear pinnae and lungs of mice at 8 wk old following treatment with Metronidazole (30 mg/kg/day; oral gavage; from 2 to 4 weeks).
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J Neuroinflammation
The gut microbiota limits systemic inflammation during neurotrophic viral CNS infection by priming tonic type I interferon signaling. [Abstract]2025 Nov 4;22(1):259. PMID: 41189008
Metronidazole solution purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Nov 4;22(1):259. [Abstract]
Sufficiently enhanced susceptibility to JE by ampicillin (A) and/or Metronidazole (M) (1 g/L; drinking water; for 21 days) treatment in C57BL/6 mice.
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NPJ Biofilms Microbiomes
Gut microbiota dysbiosis-mediated ceramides elevation contributes to corticosterone-induced depression by impairing mitochondrial function. [Abstract]2024 Oct 28;10(1):111. PMID: 39468065 -
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J Pharm Anal
Protective effects of dioscin against Parkinson's disease via regulating bile acid metabolism through remodeling gut microbiome/GLP-1 signaling. [Abstract]2023 Oct;13(10):1153-1167. PMID: 38024855 -
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Sci China Life Sci
Endometrial microbiota-dimethylglycine-Treg cell axis affects endometrial receptivity in recurrent implantation failure. [Abstract]2026 Apr;69(4):1271-1283. PMID: 41627665 -
Food Chem X
Machine learning prioritization of antibiotic residues in aquatic foods reveals exposure-driven genotoxic risk mediated by BCL2. [Abstract]2026 Feb 8:34:103646. PMID: 41756597 -
Food Res Int
Fructooligosaccharides alleviate early-life antibiotic-exposed food allergy via the Indole-3-propionic acid-AhR-Nrf2 Axis: A multi-omics prospective cohort study. [Abstract]2026 Jul 31:236:119200. PMID: 42116470 -
Int J Biol Macromol
Tremella aurantialba polysaccharides alleviate ulcerative colitis in mice by improving intestinal barrier via modulating gut microbiota and inhibiting ferroptosis. [Abstract]2024 Nov;281(Pt 4):135835. PMID: 39306158 -
Neural Regen Res
Gut microbiota dysbiosis contributes to α-synuclein-related pathology associated with C/EBPβ/AEP signaling activation in a mouse model of Parkinson's disease. [Abstract]2024 Sep 1;19(9):2081-2088. PMID: 38227539 -
Free Radic Biol Med
Gut microbiota derived butyrate enhances ferroptosis sensitivity in endometriosis through FFAR2/PPAR-γ/PINK1/Parkin mediated mitophagy. [Abstract]2025 Oct:238:640-652. PMID: 40669572 -
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Clin Transl Med
Gut microbiota of miR-30a-5p-deleted mice aggravate high-fat diet-induced hepatic steatosis by regulating arachidonic acid metabolic pathway. [Abstract]2024 Oct;14(10):e70035. PMID: 39360667 -
Cancer Immunol Res
NET-Triggered NLRP3 Activation and IL18 Release Drive Oxaliplatin-Induced Peripheral Neuropathy. [Abstract]2022 Dec 2;10(12):1542-1558. PMID: 36255412 -
Am J Chin Med
Astragaloside IV Ameliorates Colonic Adenomatous Polyps Development by Orchestrating Gut Bifidobacterium and Serum Metabolome. [Abstract]2024;52(5):1527-1554. PMID: 39164214 -
Aging Cell
BNIP3-Dependent Mitophagy Non-Autonomously Regulates Systemic Aging via NF-κB Suppression in Drosophila. [Abstract]2026 May;25(5):e70539. PMID: 42128879 -
Cell Rep
Temporal dynamics of immune cell transcriptomics in brain metastasis progression influenced by gut microbiome dysbiosis. [Abstract]2025 Feb 28;44(3):115356. PMID: 40023843 -
Cell Rep
Multi-modal Single-Cell Analysis Reveals Brain Immune Landscape Plasticity during Aging and Gut Microbiota Dysbiosis. [Abstract]2020 Dec 1;33(9):108438. PMID: 33264626 -
Neurotherapeutics
Fecal Microbiota Transplantation from Aged Mice Render Recipient Mice Resistant to MPTP-Induced Nigrostriatal Degeneration Via a Neurogenesis-Dependent but Inflammation-Independent Manner. [Abstract]2023 Sep;20(5):1405-1426. PMID: 37596429 -
Emerg Microbes Infect
2022 Dec;11(1):815-828. PMID: 35191819 -
J Ethnopharmacol
Quyushengxin formula restores the integrity of intestinal barrier by regulating the gut microbiota to ameliorate DSS-induced ulcerative colitis in mice. [Abstract]2026 Mar 1:358:120992. PMID: 41344523 -
J Agric Food Chem
Lactiplantibacillus plantarum-Derived Indole-3-lactic Acid Ameliorates Intestinal Barrier Integrity through the AhR/Nrf2/NF-κB Axis. [Abstract]2024 Apr 10. PMID: 38597152 -
CNS Neurosci Ther
Sleep Deprivation Exacerbates Ischemic Stroke Outcomes via Akkermansia Depletion and Metabolic Dysregulation. [Abstract]2026 May;32(5):e70933. PMID: 42157727 -
Ecotoxicol Environ Saf
PPARγ-responsive luciferase reporter system for high-throughput screening of chemical toxins with potential pulmonary fibrosis effects. [Abstract]2025 Nov 15:307:119433. PMID: 41273832 -
CNS Neurosci Ther
Berberine Alleviates Kainic Acid-Induced Acute Epileptic Seizures in Mice via Reshaping Gut Microbiota-Associated Lipid Metabolism. [Abstract]2025 Feb;31(2):e70253. PMID: 39915895 -
Biochem Pharmacol
MNAM enhances Blautia abundance and modulates Th17/Treg balance to alleviate diabetes in T2DM mice. [Abstract]2024 Dec;230(Pt 2):116593. PMID: 39454734 -
Life Sci
Electroacupuncture preserves intestinal barrier integrity through modulating the gut microbiota in DSS-induced chronic colitis. [Abstract]2020 Nov 15:261:118473. PMID: 32971101 -
Int Immunopharmacol
Early-life antibiotic dysbiosis impairs microbial tryptophan- nicotinic acid metabolism exacerbating food allergy in adulthood. [Abstract]2025 Jun 26:159:114888. PMID: 40403504 -
Front Aging Neurosci
Transplantation of fecal microbiota from APP/PS1 mice and Alzheimer's disease patients enhanced endoplasmic reticulum stress in the cerebral cortex of wild-type mice. [Abstract]2022 Jul 28;14:858130. PMID: 35966768 -
Sci Rep
The role and mechanism of lung microbiota in coal mine dust-induced NLRP3 inflammasome upregulate and lung injury. [Abstract]2025 Jul 2;15(1):22990. PMID: 40594884 -
Exp Neurol
Indoleamine 2, 3-dioxygenase 1 inhibition mediates the therapeutic effects in Parkinson's disease mice by modulating inflammation and neurogenesis in a gut microbiota dependent manner. [Abstract]2025 Mar:385:115142. PMID: 39793693 -
iScience
Stability and biocompatibility of hBD3 with different chiral configurations and their therapeutic efficacy in periodontitis. [Abstract]2025 Sep 25;28(11):113648. PMID: 41142128 -
iScience
AF6 regulates intestinal IgA via crosstalk between intestinal epithelial cells and immune cells in inflammatory bowel disease. [Abstract]2025 May 13;28(7):112658. PMID: 40687779 -
iScience
Gut microbiota from voluntary exercised mice protects the intestinal barrier by inhibiting neutrophil extracellular trap formation. [Abstract]2025 May 27;28(6):112763. PMID: 40585508 -
iScience
Analysis of microbiota reveals the underlying mechanism of PHF11 in the development of Enterococcus-regulated endometriotic cysts. [Abstract]2023 Oct 7;26(11):108158. PMID: 37915596 -
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Antimicrob Agents Chemother
Dihydrotanshinone I Is Effective against Drug-Resistant Helicobacter pylori In Vitro and In Vivo. [Abstract]2021 Feb 17;65(3):e01921-20. PMID: 33318002 -
Naunyn Schmiedebergs Arch Pharmacol
5-aminosalicylic acid alleviates colitis and protects intestinal barrier function by modulating gut microbiota in mice. [Abstract]2025 Apr;398(4):3681-3695. PMID: 39352537 -
J Cell Physiol
Lactobacillus plantarum alleviates irradiation-induced intestinal injury by activation of FXR-FGF15 signaling in intestinal epithelia. [Abstract]2022 Mar;237(3):1845-1856. PMID: 34881818 -
AMB Express
Odoribacter laneus protects intestinal barrier by bile acid-FXR axis in acute pancreatitis. [Abstract]2026 May 20. PMID: 42162499 -
Carcinogenesis
EphB6 deficiency in intestinal neurons promotes tumor growth in colorectal cancer by neurotransmitter GABA signaling. [Abstract]2023 Dec 2;44(8-9):682-694. PMID: 37294054 -
Mol Immunol
Alteration of intestinal microecology by oral antibiotics promotes oral squamous cell carcinoma development. [Abstract]2022 Sep:149:94-106. PMID: 35803000 -
Biochem Biophys Res Commun
Multi-omics approaches to explore the therapeutic mechanism for ginsenoside Rg1 against MASLD. [Abstract]2025 Aug 30:776:152161. PMID: 40527176 -
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Pureza y Documentación
Referencias
[1]. Scully BE. Metronidazole. Med Clin North Am. 1988 May;72(3):613-21. [Content Brief]
[2]. Dhurga DB, et al. Granular Formation during Apoptosis in Blastocystis sp. Exposed to Metronidazole (MTZ). PLoS One. 2016 Jul 29;11(7):e0155390. [Content Brief]
[3]. Chaturvedi S, et al. Mechanistic exploration of quercetin against metronidazole induced neurotoxicity in rats: Possible role of nitric oxide isoforms and inflammatory cytokines. Neurotoxicology. 2020 Jul;79:1-10. [Content Brief]
[4]. Manickam R, et al. Metronidazole Causes Skeletal Muscle Atrophy and Modulates Muscle Chronometabolism. Int J Mol Sci. 2018 Aug 16;19(8):2418. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)