Nigericin
Based on 249 publication(s) in Google Scholar
Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. Nigericin is a NLRP3 activator. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin induces pyroptosis through caspase 1/GSDMD in TNBC.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.64%
- No. CAS: 28380-24-7
- Fòrmula: C40H68O11
- Peso molecular:724.96
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Publications Citing Use of MedChemExpress (MCE) Nigericin
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Ver todos los productos específicos de isoformas Antibiotic
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Actividad biológica
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NLRP3 |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| H9 | EC50 |
0.006 μM
Compound: Nigericin
|
Antiviral activity against HIV1 RF in human H9 cells assessed as inhibition of virus-induced cytopathic effect by formazan-based conventional colorimetric technique
Antiviral activity against HIV1 RF in human H9 cells assessed as inhibition of virus-induced cytopathic effect by formazan-based conventional colorimetric technique
|
[PMID: 11430019] |
| H9 | IC50 |
0.14 μM
Compound: Nigericin
|
Cytotoxicity against human H9 cells
Cytotoxicity against human H9 cells
|
[PMID: 11430019] |
| Hepatocyte | CC50 |
>200 nM
Compound: Nigericin
|
Cytotoxicity against human primary hepatocytes
Cytotoxicity against human primary hepatocytes
|
[PMID: 38262446] |
| Hepatocyte | IC50 |
<0.001 nM
Compound: Nigericin
|
Antimicrobial activity against Plasmodium falciparum NF54 schizonts in mammalian hepatocytes after 96 hrs
Antimicrobial activity against Plasmodium falciparum NF54 schizonts in mammalian hepatocytes after 96 hrs
|
[PMID: 18212104] |
| Hepatocyte | IC50 |
<0.001 nM
Compound: Nigericin
|
Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs
Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs
|
[PMID: 18212104] |
| KM12 | IC50 |
8.48 μM
Compound: 70
|
Anticancer activity against human KM12 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
Anticancer activity against human KM12 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
|
[PMID: 33445154] |
| SW-620 | IC50 |
1.39 μM
Compound: 70
|
Anticancer activity against human SW-620 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
Anticancer activity against human SW-620 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
|
[PMID: 33445154] |
Nigericin (0-4 μg/mL; 24 h) induces pyroptosis through caspase 1/GSDMD pathway in TNBC cells[6].
Nigericin (1 μg/mL, 8 × MIC; 2 μg/mL, 16 × MIC; 196 h) is a bactericidal antibiotic against MDR gram-positive bacteria[4].
Nigericin (0-0.25 μg/mL; 24 h) inactivates Wnt/β-catenin pathway in H460 cells as an anti-cancer effect[7].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:S. aureus, Staphylococcus epidermidis, Enterococcus faecalis, E. faecium, S. pneumoniae) , and Streptococcus agalactiae
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Concentration:0 μg/mL, 0.05 μg/mL, 0.125 μg/mL, 0.25 μg/mL
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Incubation Time:24 h
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Result:Exhibited potent activity against these clinical MDR strains, with MIC values ranging from 0.004-0.25 mg/mL.
-
Cell Line:MDA-MB-231, and 4T1 cells
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Concentration:0 μg/mL, 2 μg/mL, 4 μg/mL
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Incubation Time:24 h
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Result:Showed increasing in the proteins level of caspase 1 and N-GSDMD.
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Cell Line:H460 cells
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Concentration:0.5 μM, 1 μM, 2.5 μM
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Incubation Time:24 h
-
Result:Showed downregulating in the expression of proteins of the canonical Wnt (LRP6, Wnt5a/b, and β-catenin) signaling pathway.
Nigericin (0.025 mg/kg; s.c.; every two days in 4 weeks) plus anti-PD-1 shows synergistic anti-cancer effect[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:BALB/c Mice injected orthotopically with 4T1 cells[6]
-
Dosage:0.025 mg/kg
-
Administration:Subcutaneous injection (s.c.)
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Result:Showed combination with anti-PD-1 antibody almost completely suppressed tumor growth.
-
Animal Model:Mice Infected with S. aureus USA300[4]
-
Dosage:1 mg/kg
-
Administration:Intraperitoneal injection (i.p.)
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Result:Showed reduction in the bacterial burden to 1,000-10,000-fold in the major organs.
Chemical Information
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No. CAS 28380-24-7
-
Appearance Solid
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Peso molecular 724.96
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Fòrmula C40H68O11
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Color White to off-white
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SMILES
C[C@H]1[C@](O[C@@H]2C[C@](CC[C@@H]3C)([H])O[C@@]3([H])[C@@H](C)C(O)=O)([C@@H]([C@H](OC)C2)C)O[C@](C)([C@]4([H])O[C@](C)([C@]5([H])O[C@]([C@@]([C@H](C[C@H]6C)C)([H])O[C@@]6(O)CO)([H])C[C@@H]5C)CC4)C1
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Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (249)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Pulsed electromagnetic fields inhibit atherosclerosis by regulating pyroptosis through membrane tension-mediated mechanosensitive channels. [Abstract]2025 Nov 28;10(1):388. PMID: 41309549 -
Signal Transduct Target Ther
Oleic acid restores the impaired antitumor immunity of γδ-T cells induced by palmitic acid. [Abstract]2025 Jul 3;10(1):209. PMID: 40603316 -
Signal Transduct Target Ther
2024 Dec 30;9(1):367. PMID: 39737965
Nigericin purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Dec 30;9(1):367. [Abstract]
Cellular BiP-IRF2BP2 interactions shown by Western blot analysis of co-immunoprecipitation in MG132-pretreated (5 μM, 2 h) peritoneal macrophages which were incubated with Nigericin (10 μM), Valinomycin (10 μM) and MG132 (5 μM) for 3 h in calibration buffer under different pH (7.2, 7.0, 6.8, 6.6).
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Nature
2026 Jul;655(8121):240-250. PMID: 42236947 -
Cell Metab
Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis. [Abstract]2020 May 5;31(5):892-908.e11. PMID: 32375062 -
Cell Res
Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate. [Abstract]2023 Nov;33(11):835-850. PMID: 37726403 -
Nat Immunol
Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response. [Abstract]2025 Oct;26(10):1660-1672. PMID: 40954252 -
Bioact Mater
A bioinspired and high-strengthed hydrogel for regeneration of perforated temporomandibular joint disc: Construction and pleiotropic immunomodulatory effects. [Abstract]2022 Jul 20:25:701-715. PMID: 37056268 -
Cell Host Microbe
Mycobacterium tuberculosis suppresses host DNA repair to boost its intracellular survival. [Abstract]2023 Nov 8;31(11):1820-1836.e10. PMID: 37848028 -
Nat Cell Biol
TOLLIP targets GSDME-NT-carrying endocytic vesicles for autophagy to regulate pyroptosis and chemotherapy efficacy. [Abstract]2026 Apr;28(4):812-827. PMID: 41803502 -
J Extracell Vesicles
VAMP4/STX8 Mediate the Autophagic Secretion of Mitochondria and Promote TAMs Polarization in HNSCC. [Abstract]2026 Apr;15(4):e70276. PMID: 41979085 -
J Extracell Vesicles
Hypoxia promotes EV secretion by impairing lysosomal homeostasis in HNSCC through negative regulation of ATP6V1A by HIF-1α. [Abstract]2023 Feb;12(2):e12310. PMID: 36748335 -
Autophagy
Bafetinib enhances anti-tumor immunity by activating the NLRP3 inflammasome in macrophage. [Abstract]2026 Jul;22(7):1484-1502. PMID: 41906654 -
Autophagy
High-fat diet exacerbates experimental colitis by inhibiting lysosomal function via the STAT3-TFEB Axis. [Abstract]2026 May 28:1-24. PMID: 42165414 -
Nat Commun
Mast cells boost anti-tumor potency of MAIT cells via inflammasome-dependent secretion of IL-18. [Abstract]2025 Jul 2;16(1):6074. PMID: 40603850 -
Nat Commun
2025 Jul 18;16(1):6621. PMID: 40681515 -
ACS Nano
Combinatorial Design of Fatty Acid-Incorporated Plasmid Lipid Nanoparticles Drives Dendritic Cell Hyperactivation for Enhanced Cancer Immunotherapy. [Abstract]2026 May 5;20(17):13196-13212. PMID: 42003370 -
J Adv Res
Restoring cardiolipin homeostasis mitigates cerebral ischemia-reperfusion injury by suppressing ATG5-mediated neuronal autophagy-dependent ferroptosis. [Abstract]2026 Mar 12:S2090-1232(26)00234-1. PMID: 41831680 -
J Adv Res
Tussilagone attenuated cigarette smoke-induced chronic obstructive pulmonary disease through regulating Nrf2 and NF-κB/NLRP3 inflammasome via directly targeting cysteine 434 of KEAP1. [Abstract]2025 Jul 14:S2090-1232(25)00544-2. PMID: 40669599 -
Neuron
2026 Mar 4;114(5):868-883.e7. PMID: 41558486 -
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J Am Chem Soc
Combined Cellular Thermometry Reveals That Salmonella typhimurium Warms Macrophages by Inducing a Pyroptosis-like Phenotype. [Abstract]2022 Oct 26;144(42):19396-19409. PMID: 36228296 -
Redox Biol
Ultrasmall Cu2-xSe nanoparticles alleviate vascular calcification through inhibiting oxidative stress and NF-κB/NLRP3-mediated inflammation. [Abstract]2025 Dec 3:89:103961. PMID: 41353801 -
Redox Biol
Synthetic anticoagulant octaparin targets mitochondrial cardiolipin-GSDMD axis to rescue redox homeostasis in sepsis. [Abstract]2025 Sep 22:87:103877. PMID: 40992080 -
J Nanobiotechnology
Hydrophilic nanofibers with aligned topography modulate macrophage-mediated host responses via the NLRP3 inflammasome. [Abstract]2023 Aug 14;21(1):269. PMID: 37574546 -
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Genes Dis
Protective effects of IRG1/itaconate on acute colitis through the inhibition of gasdermins-mediated pyroptosis and inflammation response. [Abstract]2022 Jun 20;10(4):1552-1563. PMID: 37397544 -
Adv Sci (Weinh)
Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease. [Abstract]2025 Dec 29:e15138. PMID: 41462565 -
Cell Rep Med
HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer. [Abstract]2026 Feb 18:102630. PMID: 41713410 -
Sci Adv
Lysosomal zinc nanomodulation blocks macrophage pyroptosis for counteracting atherosclerosis progression. [Abstract]2025 Jun 27;11(26):eadu3919. PMID: 40561010 -
Cell Death Differ
ALKBH5 aggravates scarring after glaucoma surgery via m6A-YTHDF2-mediated NLRP3 mRNA stabilization. [Abstract]2026 May 31. PMID: 42218253 -
Biomaterials
2024 Mar:305:122466. PMID: 38184960 -
Biomaterials
Lipid nanoparticle-assisted miR29a delivery based on core-shell nanofibers improves tendon healing by cross-regulation of the immune response and matrix remodeling. [Abstract]2022 Dec:291:121888. PMID: 36403324 -
Cell Death Differ
Ezh2 competes with p53 to license lncRNA Neat1 transcription for inflammasome activation. [Abstract]2022 Oct;29(10):2009-2023. PMID: 35568718 -
Cell Death Differ
2022 Feb;29(2):439-450. PMID: 34511601 -
Mol Biomed
ML345 is a potent and selective NLRP3 inflammasome inhibitor with anti-inflammatory activity. [Abstract]2025 Nov 13;6(1):108. PMID: 41231359 -
Pharmacol Res
Plumbagin ameliorates multiple sclerosis by inducing DDX3X-mediated stress granule assembly in mice. [Abstract]2026 Jul:229:108257. PMID: 42167385 -
Cell Death Dis
2024 Jan 18;15(1):66. PMID: 38238307 -
Cell Death Dis
Dehydroepiandrosterone exacerbates nigericin-induced abnormal autophagy and pyroptosis via GPER activation in LPS-primed macrophages. [Abstract]2022 Apr 19;13(4):372. PMID: 35440074 -
Cell Death Dis
2021 Dec 14;12(12):1159. PMID: 34907173 -
Cell Death Dis
Silencing lncRNA Lfar1 alleviates the classical activation and pyoptosis of macrophage in hepatic fibrosis. [Abstract]2020 Feb 18;11(2):132. PMID: 32071306 -
Cancer Lett
Induction of IFIT1/IFIT3 and inhibition of Bcl-2 orchestrate the treatment of myeloma and leukemia via pyroptosis. [Abstract]2024 Apr 28:588:216797. PMID: 38462032 -
Int J Biol Sci
Pyroptotic Macrophage-Derived Microvesicles Accelerate Formation of Neutrophil Extracellular Traps via GSDMD-N-expressing Mitochondrial Transfer during Sepsis. [Abstract]2024 Jan 1;20(2):733-750. PMID: 38169726 -
Cell Commun Signal
Helicobacter pylori infection promotes M1 macrophage polarization and gastric inflammation by activation of NLRP3 inflammasome via TNF/TNFR1 axis. [Abstract]2025 Jan 6;23(1):6. PMID: 39762835 -
Cell Commun Signal
Identification of a covalent NEK7 inhibitor to alleviate NLRP3 inflammasome-driven metainflammation. [Abstract]2024 Nov 25;22(1):565. PMID: 39587676 -
J Exp Med
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition. [Abstract]2023 Mar 6;220(3):e20221316. PMID: 36520461 -
J Exp Med
2022 Oct 3;219(10):e20212117. PMID: 36129453 -
J Neuroinflammation
Erbin protects against sepsis-associated encephalopathy by attenuating microglia pyroptosis via IRE1α/Xbp1s-Ca2+ axis. [Abstract]2022 Sep 28;19(1):237. PMID: 36171629 -
J Neuroinflammation
Divanillyl sulfone suppresses NLRP3 inflammasome activation via inducing mitophagy to ameliorate chronic neuropathic pain in mice. [Abstract]2021 Jun 24;18(1):142. PMID: 34162415 -
Crit Care
Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury. [Abstract]2021 Oct 12;25(1):356. PMID: 34641966 -
Phytomedicine
Nuciferine ameliorates steroid-induced osteonecrosis of the femoral head by inhibiting BMSCs ferroptosis via HIF-1α. [Abstract]2026 Jun:155:158070. PMID: 41861683 -
Phytomedicine
Da-Bu-Yin-Wan rescues cognitive deficits in aging and Alzheimer's disease models by Wnt/β-catenin-dependent restoration of lysosomal acidification. [Abstract]2026 Apr:153:157916. PMID: 41662806 -
Phytomedicine
Maiwei Yangfei decoction protects against pulmonary fibrosis by suppressing NLRP3 inflammasome-mediated pyroptosis of alveolar macrophage. [Abstract]2025 Sep:145:157041. PMID: 40652799 -
Phytomedicine
2025 Apr:139:156563. PMID: 40023068 -
Phytomedicine
Tryptanthrin suppresses multiple inflammasome activation to regulate NASH progression by targeting ASC protein. [Abstract]2024 May 28:131:155758. PMID: 38843643
Nigericin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 May 28:131:155758. [Abstract]
Nigericin (10 μM; 30 min) inhibits caspase-1 cleavage and IL-1β secretion in BMDMs.
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Phytomedicine
Amentoflavone mitigates doxorubicin-induced cardiotoxicity by suppressing cardiomyocyte pyroptosis and inflammation through inhibition of the STING/NLRP3 signalling pathway. [Abstract]2023 Aug:117:154922. PMID: 37321078 -
Phytomedicine
Anti-inflammatory effect of Danhong injection through inhibition of GSDMD-mediated pyroptosis. [Abstract]2023 May:113:154743. PMID: 36893672
Nigericin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 May:113:154743. [Abstract]
Priming with LPS (1 μg/mL; 4 h) and activating with Nigericin (10 μM; 2 h) induces NLRP3 expression, caspase-1 cleavage, and GSDMD cleavage in BMDMs.
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Mater Today Bio
Nanotube topography inhibits NLRP3 inflammasome activation by reducing microtubule glutamylation. [Abstract]2025 May 10:32:101838. PMID: 40487178 -
Acta Pharmacol Sin
Alkalization of the intracellular pH reprograms TNF-α signaling from inflammatory NF-κB activation to tumoricidal RIP kinase-dependent necroptosis in cancer cells. [Abstract]2026 Apr 8. PMID: 41951772 -
Cell Death Discov
NRG1/PDGFC loop between fibroblasts and cancer cells drives paclitaxel resistance via ferroptosis suppression in breast cancer. [Abstract]2025 Nov 10;11(1):520. PMID: 41213930 -
Acta Pharmacol Sin
2021 Nov;42(11):1913-1920. PMID: 34561552 -
Cell Death Discov
IP3R1 regulates Ca2+ transport and pyroptosis through the NLRP3/Caspase-1 pathway in myocardial ischemia/reperfusion injury. [Abstract]2021 Feb 10;7(1):31. PMID: 33568649 -
Biomater Res
Purinergic Receptor Nanoimmunoamplifiers Potentiate Chemoimmunotherapy Efficacy in Hepatocellular Carcinoma. [Abstract]2025 Nov 6:29:0278. PMID: 41209313 -
J Transl Med
L-Fucose alleviates inflammation, pyroptosis and mitochondrial injury in obesity-related cardiac injury via TLR4/MyD88/NF-κB pathway. [Abstract]2025 Dec 8;23(1):1385. PMID: 41361467 -
Proc Natl Acad Sci U S A
Monensin suppresses EMT-driven cancer cell motility by inducing Golgi pH-dependent exocytosis of GOLIM4. [Abstract]2025 Jul 15;122(28):e2501347122. PMID: 40632561 -
Proc Natl Acad Sci U S A
Bioenergetic suppression by redox-active metabolites promotes antibiotic tolerance in Pseudomonas aeruginosa. [Abstract]2024 Nov 12;121(46):e2406555121. PMID: 39503891 -
Dev Cell
PCP-B peptides and CrRLK1L receptor kinases control pollination via pH gating of aquaporins in Arabidopsis. [Abstract]2025 May 5;60(9):1336-1347.e5. PMID: 39793583 -
Apoptosis
Phillyrin promotes flap survival by mitigating pyroptosis through the TLR4/NF-κB/NLRP3 signaling pathway. [Abstract]2026 Jan 10;31(1):36. PMID: 41518527 -
Int J Biol Macromol
A high-throughput reporter assay for screening potential gasdermin D inhibitors from natural products. [Abstract]2026 Jan;339(Pt 2):150110. PMID: 41500275 -
Int J Biol Macromol
Glutathion peroxidase 4 (GPX4) and Ribosomal Protein L40 (RPL40) participate in arsenic induced progression of renal cell carcinoma by regulating the NLRP3 mediated classic pyroptosis pathway. [Abstract]2025 Apr 14:143129. PMID: 40239794 -
Int J Mol Med
Hypothermic machine perfusion protects DCD graft liver from ischemia‑reperfusion injury by enhancing macrophage efferocytosis via KLF2‑NLRP3 signaling. [Abstract]2026 Apr;57(4):85. PMID: 41645764 -
Int J Mol Med
Semaglutide attenuates seizure severity and ameliorates cognitive dysfunction by blocking the NLR family pyrin domain containing 3 inflammasome in pentylenetetrazole‑kindled mice. [Abstract]2021 Dec;48(6):219. PMID: 34676876 -
Mol Med
HSPA1A inhibits pyroptosis and neuroinflammation after spinal cord injury via DUSP1 inhibition of the MAPK signaling pathway. [Abstract]2025 Feb 9;31(1):53. PMID: 39924492 -
Mol Med
Formononetin ameliorates polycystic ovary syndrome through suppressing NLRP3 inflammasome. [Abstract]2025 Jan 27;31(1):27. PMID: 39871124 -
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Plant Physiol
The mid-to-late-stage fungal effector EqBPIE1 mediates chloroplast-to-nucleus immune signaling and broad-spectrum resistance. [Abstract]2026 May 26:kiag315. PMID: 42184980 -
Phytother Res
Malvidin-3-O-Rhamnoside Alleviates Klebsiella pneumoniae-Induced Acute Lung Injury by Regulating Macrophage-Mediated Inflammatory and Oxidative Pathways. [Abstract]2026 Jun 14. PMID: 42290103 -
Phytother Res
Evodiamine alleviates lipopolysaccharide-induced pulmonary inflammation and fibrosis by activating apelin pathway. [Abstract]2021 Jun;35(6):3406-3417. PMID: 33657655 -
Free Radic Biol Med
Study on the role of TIGAR in regulating mitochondrial function and inhibiting pyroptosis of breast cancer cells. [Abstract]2026 Mar 1:245:463-477. PMID: 41512973 -
Free Radic Biol Med
NAD+ rescues Phosphatidylinositol-induced granulosa cell Pyroptosis to restore follicular development in PCOS. [Abstract]2025 Sep 11:S0891-5849(25)00976-1. PMID: 40945625 -
Clin Transl Med
Ubiquitin-specific protease 25 improves myocardial ischemia-reperfusion injury by deubiquitinating NLRP3 and negatively regulating NLRP3 inflammasome activity in cardiomyocytes. [Abstract]2025 Feb;15(2):e70243. PMID: 39985261 -
Clin Transl Med
2025 Mar;15(3):e70263. PMID: 40045452 -
Clin Transl Med
2024 Mar;14(3):e1623. PMID: 38488468 -
Am J Chin Med
Using Network Pharmacology for Systematic Understanding of Geniposide in Ameliorating Inflammatory Responses in Colitis Through Suppression of NLRP3 Inflammasome in Macrophage by AMPK/Sirt1 Dependent Signaling. [Abstract]2020;48(7):1693-1713. PMID: 33202149 -
Cell Rep
The Hippo pathway kinase MST1 mediates a feedback loop to maintain NLRP3 inflammasome homeostasis. [Abstract]2025 Jul 26;44(8):116076. PMID: 40716062 -
Cell Rep
Controlling mitochondrial membrane architecture via MIC60 determines viral replication to promote anti-viral immunity. [Abstract]2025 Jul 22;44(7):115922. PMID: 40628273 -
Aging Cell
Aerobic Exercise Restores Hippocampal Neurogenesis and Cognitive Function by Decreasing Microglia Inflammasome Formation Through Irisin/NLRP3 Pathway. [Abstract]2025 Apr 7:e70061. PMID: 40192010 -
Cell Rep
Mitochondrial transplantation rescues Ca2+ homeostasis imbalance and myocardial hypertrophy in SLC25A3-related hypertrophic cardiomyopathy. [Abstract]2024 Dec 12;43(12):115065. PMID: 39671292 -
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Br J Pharmacol
The deubiquitinase YOD1 in cardiomyocytes mediates septic cardiomyopathy by deubiquitinating and thus stabilizing the NLRP3 inflammasome. [Abstract]2026 Jul;183(13):3558-3577. PMID: 41913386 -
Brain Behav Immun
Activation of GLP-1R ameliorates microglial pyroptosis after spinal cord injury by restoring FANCC expression. [Abstract]2026 Jan 22:134:106295. PMID: 41580096 -
Chin Med
Celastrol ameliorates atherosclerosis by inhibiting TLR4/STAT3/NLRP3-mediated macrophage pyroptosis. [Abstract]2026 May 28;21(1):149. PMID: 42210326 -
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J Med Chem
Deep-Learning-Driven Discovery of SN3-1, a Potent NLRP3 Inhibitor with Therapeutic Potential for Inflammatory Diseases. [Abstract]2024 Oct 10;67(19):17833-17854. PMID: 39302813 -
Atherosclerosis
Isolinderalactone alleviates atherosclerosis by inhibiting NLRP3 inflammasome activation and inflammatory response in macrophages. [Abstract]2026 Jan 26:414:120648. PMID: 41759391 -
Front Immunol
Inflammasome-Induced Osmotic Pressure and the Mechanical Mechanisms Underlying Astrocytic Swelling and Membrane Blebbing in Pyroptosis. [Abstract]2021 Jul 7:12:688674. PMID: 34305921 -
J Ethnopharmacol
Salvianolic acid C, a novel pyroptosis inhibitor, attenuates podocyte injury in diabetic kidney disease through regulating miRNA-21/A20 pathway. [Abstract]2026 Jun 28:365:121589. PMID: 41903586 -
J Ethnopharmacol
Guhan Yangsheng Jing alleviates sleep deprivation-induced neuronal injury via neurotransmitter rebalancing, mitochondrial protection, and inhibition of pyroptosis. [Abstract]2026 Apr 6:360:121209. PMID: 41539636 -
Neurosci Bull
OGT-Mediated O-GlcNAcylation of ATF2 Protects Against Sepsis-Associated Encephalopathy by Inhibiting Microglial Pyroptosis. [Abstract]2025 May 24. PMID: 40411666 -
J Ethnopharmacol
Shuangdan Jiedu Decoction improved LPS-induced acute lung injury by regulating both cGAS-STING pathway and inflammasome. [Abstract]2024 Aug 17:118661. PMID: 39159837 -
J Ethnopharmacol
The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB. [Abstract]2022 Jan 30:283:114694. PMID: 34601084 -
J Agric Food Chem
Natural Dietary Flavonoid Apigenin Mitigates Ulcerative Colitis via Modulating the AMPK/NF-κB/NLRP3 Signaling Axis. [Abstract]2025 Dec 22. PMID: 41428381 -
J Agric Food Chem
Ginsenoside Rg1 Suppresses Pyroptosis via the NF-κB/NLRP3/GSDMD Pathway to Alleviate Chronic Atrophic Gastritis In Vitro and In Vivo. [Abstract]2024 Jun 10. PMID: 38855973 -
Eur J Med Chem
Development of novel oridonin analogs as specifically targeted NLRP3 inflammasome inhibitors for the treatment of dextran sulfate sodium-induced colitis. [Abstract]2023 Jan 5;245(Pt 2):114919. PMID: 36399877
Nigericin purchased from MedChemExpress. Usage Cited in: Eur J Med Chem. 2023 Jan 5;245(Pt 2):114919. [Abstract]
Nigericin (10 μM; 0.5 h) combined with LPS (1 μg/mL; 4.5 h) markedly increases the expression of cleaved caspase-1 and IL-1β in the culture medium of THP-M cells.
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CNS Neurosci Ther
Forsythoside A Alleviates Neuroinflammatory Damage via Inhibiting TLR4/NF-κB/NLRP3 Activation-Induced Astrocyte Pyroptosis in Cerebral Ischemia-Reperfusion. [Abstract]2026 Apr;32(4):e70867. PMID: 41948887 -
CNS Neurosci Ther
Mechanism of Hypoxia-Induced HMGB1 Regulating NLRP3 Inflammasome/Caspase-1 Pathway-Mediated Pyroptosis in Myocardial Ischemia Reperfusion Injury Through the Nrf2/HO-1 Pathway. [Abstract]2025 Dec;31(12):e70661. PMID: 41378869 -
CNS Neurosci Ther
Aerobic Exercise Training Exerts Neuroprotective Effects in Alzheimer's Disease Mice by Regulating Endoplasmic Reticulum Stress-Autophagy Pathway-Mediated Pyroptosis. [Abstract]2025 Nov;31(11):e70620. PMID: 41249871 -
Ecotoxicol Environ Saf
VX-765 attenuates silica-induced lung inflammatory injury and fibrosis by modulating alveolar macrophages pyroptosis in mice. [Abstract]2023 Jan 1:249:114359. PMID: 36508797 -
CNS Neurosci Ther
Electroacupuncture ameliorates postoperative cognitive dysfunction and associated neuroinflammation via NLRP3 signal inhibition in aged mice. [Abstract]2022 Mar;28(3):390-400. PMID: 34951130 -
Biochem Pharmacol
Tamibarotene directly targets the NACHT domain of NLRP3 to alleviate acute myocardial infarction. [Abstract]2025 Feb 12:234:116801. PMID: 39952330 -
Biochem Pharmacol
Disordered gut microbiota promotes atrial fibrillation by aggravated conduction disturbance and unbalanced linoleic acid/SIRT1 signaling. [Abstract]2023 Jul:213:115599. PMID: 37196685 -
Biochem Pharmacol
Nigericin exerts anticancer effects through inhibition of the SRC/STAT3/BCL-2 in osteosarcoma. [Abstract]2022 Apr:198:114938. PMID: 35114189 -
Life Sci
2026 Jan 1:384:124108. PMID: 41314595 -
Life Sci
Corilagin attenuates intestinal ischemia/reperfusion injury in mice by inhibiting ferritinophagy-mediated ferroptosis through disrupting NCOA4-ferritin interaction. [Abstract]2023 Dec 1:334:122176. PMID: 37858718 -
Life Sci
Identification of inflammation related lncRNAs and Gm33647 as a potential regulator in septic acute lung injury. [Abstract]2021 Oct 1:282:119814. PMID: 34298039 -
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Inflamm Res
Cynarin inhibits microglia-induced pyroptosis and neuroinflammation via Nrf2/ROS/NLRP3 axis after spinal cord injury. [Abstract]2024 Nov;73(11):1981-1994. PMID: 39340662 -
Inflamm Res
Corynoline alleviates hepatic ischemia-reperfusion injury by inhibiting NLRP3 inflammasome activation through enhancing Nrf2/HO-1 signaling. [Abstract]2024 Dec;73(12):2069-2085. PMID: 39294398 -
J Neuroimmune Pharmacol
HucMSCs-Derived Extracellular Vesicles Deliver RPS27A Protein to Manipulate the MDM2-P53 Axis and Ameliorate Neurological Dysfunction in Parkinson's Disease. [Abstract]2025 May 8;20(1):52. PMID: 40338442 -
Anal Chim Acta
2025 Feb 15:1339:343637. PMID: 39832873 -
Transl Res
A dual action small molecule enhances azoles and overcomes resistance through co-targeting Pdr5 and Vma1. [Abstract]2022 Sep:247:39-57. PMID: 35452875 -
Cells
Mitochondrial Fragmentation Induced by the CFTR Modulators Lumacaftor and Ivacaftor in Immortalized Cystic Fibrosis Cell Lines. [Abstract]2025 Oct 15;14(20):1601. PMID: 41148816 -
J Am Heart Assoc
Colchicine Ameliorates Dilated Cardiomyopathy Via SIRT2-Mediated Suppression of NLRP3 Inflammasome Activation. [Abstract]2022 Jul 5;11(13):e025266. PMID: 35766262 -
Pharm Biol
Senkyunolide A inhibits the progression of osteoarthritis by inhibiting the NLRP3 signalling pathway. [Abstract]2022 Dec;60(1):535-542. PMID: 35225151 -
Front Microbiol
Autophagy Participates in Lysosomal Vacuolation-Mediated Cell Death in RGNNV-Infected Cells. [Abstract]2020 Apr 30;11:790. PMID: 32425913 -
Eur J Pharmacol
Inhibition of α-synuclein aggregation by MCC950 attenuates dopaminergic neuronal damage in MN9D cells. [Abstract]2025 May 26:1001:177774. PMID: 40436242 -
J Gastroenterol
Heparan sulfate acts as an activator of the NLRP3 inflammasome promoting inflammatory response in the development of acute pancreatitis. [Abstract]2024 Sep;59(9):869-879. PMID: 38864913 -
Cell Biol Toxicol
Vitamin D3/VDR inhibits inflammation through NF-κB pathway accompanied by resisting apoptosis and inducing autophagy in abalone Haliotis discus hannai. [Abstract]2023 Jun;39(3):885-906. PMID: 34637036 -
Int Immunopharmacol
Yueju pill and its active component- Myricetin attenuate the reinstatement of methamphetamine-seeking behavior in mice. [Abstract]2025 Sep 26:166:115601. PMID: 41014771 -
Int Immunopharmacol
Targeting PARK7: Sodium 4-Phenylbutyrate shields endothelial cells from oxidative stress and GSDME-mediated Pyroptosis in acute lung injury. [Abstract]2025 Aug 19:164:115386. PMID: 40834532 -
Int Immunopharmacol
Perillaldehyde protect chondrocytes from mitophagy-associated apoptosis and NLRP3-mediated inflammation by regulating ALOX5/NF-kB signaling in osteoarthritis. [Abstract]2025 May 15:158:114820. PMID: 40378435 -
Int Immunopharmacol
Modulating the NLRP3 Inflammasome: Acitretin as a potential treatment for Sepsis-induced acute lung injury. [Abstract]2025 Apr 24:153:114504. PMID: 40187888 -
Int Immunopharmacol
Genome-wide screen based on 2DG activated NLRP3 inflammasome reveals the priming signal of TLR2/4 to IKKβ but not IKKα. [Abstract]2024 Dec 9:145:113781. PMID: 39657538 -
Int Immunopharmacol
Role of deubiquitinase USP47 in cardiac function alleviation and anti-inflammatory immunity after myocardial infarction by regulating NLRP3 inflammasome-mediated pyroptotic signal pathways. [Abstract]2024 Jun 7:136:112346. PMID: 38850785 -
Int Immunopharmacol
Protective effect of Timosaponin AIII on Escherichia coli-induced endometritis in mice through inhibiting inflammatory response and regulating uterine microbiota structure. [Abstract]2024 Mar 30:130:111649. PMID: 38367462 -
Int Immunopharmacol
2023 Jul:120:110292. PMID: 37182452 -
Int Immunopharmacol
Ursolic acid alleviates Kupffer cells pyroptosis in liver fibrosis by the NOX2/NLRP3 inflammasome signaling pathway. [Abstract]2022 Dec;113(Pt A):109321. PMID: 36252479 -
Int Immunopharmacol
A tyrosine catabolic intermediate 4-hydroxyphenylpyruate attenuates murine endotoxic shock by blocking NLRP3 inflammasome activation. [Abstract]2022 Oct:111:109098. PMID: 35944460 -
Int Immunopharmacol
Psoralidin, a major component of Psoraleae Fructus, induces inflammasome activation and idiosyncratic liver injury. [Abstract]2021 Mar:92:107352. PMID: 33422760 -
Mol Neurobiol
PAF Receptor Inhibition Attenuates Neuronal Pyroptosis in Cerebral Ischemia/Reperfusion Injury. [Abstract]2021 Dec;58(12):6520-6539. PMID: 34562185 -
Inflammation
Toll-Like Receptor 9 Aggravates Pulmonary Fibrosis by Promoting NLRP3-Mediated Pyroptosis of Alveolar Epithelial Cells. [Abstract]2024 Oct;47(5):1744-1761. PMID: 38498270 -
Inflammation
CHRFAM7A Overexpression Attenuates Cerebral Ischemia-Reperfusion Injury via Inhibiting Microglia Pyroptosis Mediated by the NLRP3/Caspase-1 pathway. [Abstract]2021 Jun;44(3):1023-1034. PMID: 33405023 -
Probiotics Antimicrob Proteins
Bifidobacterium breve BBr60 Enhances SCFA Levels and Restores NLRP3/NLRP6 Balance in the Gut to Improve Motor Deficits in PD Mice. [Abstract]2025 Jun 6. PMID: 40478433 -
Biogerontology
Upregulation of LXRβ/ABCA1 pathway alleviates cochlear hair cell senescence of C57BL/6 J mice via reducing lipid droplet accumulation. [Abstract]2025 Jan 31;26(2):49. PMID: 39890652 -
J Ovarian Res
Nicotinamide mononucleotide improves the ovarian reserve of POI by inhibiting NLRP3-mediated pyroptosis of ovarian granulosa cells. [Abstract]2024 Nov 26;17(1):236. PMID: 39593096 -
Chem Biol Interact
4-Hydroxybenzoic acid restrains Nlrp3 inflammasome priming and activation via disrupting PU.1 DNA binding activity and direct antioxidation. [Abstract]2024 Dec 1:404:111262. PMID: 39389441 -
Bioorg Chem
Aucubin attenuates neonatal hypoxic-ischemic brain injury by suppressing NLRP3 inflammasome-mediated microglial pyroptosis. [Abstract]2026 Jan:168:109332. PMID: 41365065 -
Tissue Eng Regen Med
Exosomes Derived from Rejuvenated Stem Cells Inactivate NLRP3 Inflammasome and Pyroptosis of Nucleus Pulposus Cells via the Transfer of Antioxidants. [Abstract]2024 Oct;21(7):1061-1077. PMID: 39060654 -
Molecules
Eriodictyol and Homoeriodictyol Improve Memory Impairment in Aβ25-35-Induced Mice by Inhibiting the NLRP3 Inflammasome. [Abstract]2022 Apr 12;27(8):2488. PMID: 35458684 -
Sci Rep
Metrnl ameliorates ulcerative colitis by inhibiting NLRP3 inflammasome activation via ASC. [Abstract]2026 Jun 11. PMID: 42277107 -
PLoS Pathog
African swine fever virus pEP364R acts as an important inflammatory-inducing factor to activate NLRP3 inflammasome-mediated pyroptosis by regulating DDX3X. [Abstract]2026 Feb 25;22(2):e1013874. PMID: 41739885 -
Sci Rep
ARL8B regulates lysosomal function and predicts poor prognosis in hepatocellular carcinoma. [Abstract]2025 Apr 10;15(1):12278. PMID: 40210693 -
Sci Rep
Ocifisertib alleviates the gasdermin D-independent pyroptosis of nucleus pulposus cells by targeting GSDME. [Abstract]2025 Apr 17;15(1):13280. PMID: 40247083 -
PLoS Pathog
2024 Jul 22;20(7):e1012398. PMID: 39038050 -
Cancer Sci
Pyroptotic macrophages promote proliferation and chemotherapy resistance of peripheral T-cell lymphoma via TLR4 signaling pathway. [Abstract]2024 Jul;115(7):2444-2460. PMID: 38613253 -
Virol Sin
ASFV pA137R protein triggers inflammatory response by inducing NF-κB signaling pathway and facilitating NLRP3 inflammasome assembly. [Abstract]2026 May 29:S1995-820X(26)00086-6. PMID: 42217584 -
Mol Cell Biochem
Hirudin ameliorates myocardial ischemia-reperfusion injury in a rat model of hemorrhagic shock and resuscitation: roles of NLRP3-signaling pathway. [Abstract]2024 Jan;479(1):63-72. PMID: 36988778 -
J Cell Mol Med
MSC derived EV loaded with miRNA-22 inhibits the inflammatory response and nerve function recovery after spinal cord injury in rats. [Abstract]2021 Nov;25(21):10268-10278. PMID: 34609045 -
J Cell Mol Med
New mechanism of nerve injury in Alzheimer's disease: β-amyloid-induced neuronal pyroptosis. [Abstract]2020 Jul;24(14):8078-8090. PMID: 32521573
Nigericin purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2020 Jul;24(14):8078-8090. [Abstract]
LPS + Nigericin is used to induce pyroptosis as a positive control group.
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Appl Microbiol Biotechnol
Mycoepoxydiene suppresses HeLa cell growth by inhibiting glycolysis and the pentose phosphate pathway. [Abstract]2017 May;101(10):4201-4213. PMID: 28224194 -
Metabolites
Pyrroloquinoline Quinone Mitigates Type 2 Diabetes-Induced Cardiac Injury Through Mitochondrial Quality Control and Inhibition of NLRP3-Dependent Pyroptosis. [Abstract]2026 May 19;16(5):340. PMID: 42188049 -
Neurochem Res
Electroacupuncture Stimulation of the Head Motor Area Alleviates Brain Cell Pyroptosis and Neurobehaviors in Stroke Rats Through the NF-κB/NLRP3 Signaling Axis. [Abstract]2026 Apr 27;51(3):146. PMID: 42043662 -
ACS Infect Dis
Rv2647-Mediated NLRP3 Ubiquitination Inhibits Macrophage Pyroptosis and Promotes Mycobacterium tuberculosis Survival. [Abstract]2025 Oct 10;11(10):2739-2753. PMID: 41032685 -
iScience
SENP3 protects hepatocyte from pyroptosis during acute liver injury through deSUMOylation of HNRNPL. [Abstract]2025 Jul 7;28(8):113067. PMID: 40792025 -
iScience
2021 Sep 25;24(10):103170. PMID: 34646996 -
FASEB J
The Mechanism of Action of NMN in Inhibiting NLRP3 Acetylation-Mediated Granulosa Cell Pyroptosis to Improve Ovarian Reserve Function in Ionizing Radiation-Exposed Mice. [Abstract]2025 Dec 31;39(24):e71335. PMID: 41395774 -
FASEB J
ADSCs-EVs Carrying circITCH Inhibit Pyroptosis of Renal Tubular Epithelial Cells and Alleviate LPS-Induced Acute Kidney Injury. [Abstract]2026 Jan 15;40(1):e71285. PMID: 41445440 -
Biochim Biophys Acta Mol Cell Res
FOSL1 regulates hyperproliferation and NLRP3-mediated inflammation of psoriatic keratinocytes through the NF-kB signaling via transcriptionally activating TRAF3. [Abstract]2024 Apr;1871(4):119689. PMID: 38367916 -
Fish Shellfish Immunol
2024 Aug 13:109837. PMID: 39147179 -
J Virol
2023 Dec 21;97(12):e0133823. PMID: 38009916 -
J Biol Chem
The ER stress sensor inositol-requiring enzyme 1α in Kupffer cells promotes hepatic ischemia-reperfusion injury. [Abstract]2022 Jan;298(1):101532. PMID: 34953853 -
Ther Adv Med Oncol
Methotrexate enhances antigen presentation and maturation of tumour antigen-loaded dendritic cells through NLRP3 inflammasome activation: a strategy for dendritic cell-based cancer vaccine. [Abstract]2021 Jan 21:13:1758835920987056. PMID: 33613696 -
Naunyn Schmiedebergs Arch Pharmacol
Tinosinenside A inhibits neuroinflammation and protects HT22 cells by suppressing the TLR4/NF-κB/NLRP3 signaling pathway in BV2 cells. [Abstract]2025 Jul;398(7):8947-8962. PMID: 39878812 -
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Neurotox Res
Tubuloside B Alleviates Aβ25-35 Induced PC12 Cell Injury by Attenuating Pyroptosis, Apoptosis and Excessive Autophagy. [Abstract]2026 Mar 19;44(2):12. PMID: 41854817 -
J Hepatocell Carcinoma
Integrated Transcriptomic Analysis Leveraging Single-Cell and Bulk RNA Sequencing Data to Uncover Pyroptosis-Related Prognostic Signatures in HCC. [Abstract]2025 Dec 24:12:2971-2988. PMID: 41467099 -
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Vet Res
2025 Oct 16;56(1):199. PMID: 41102826 -
Viruses
2022 Aug 6;14(8):1734. PMID: 36016355 -
Metab Brain Dis
2022 Apr;37(4):1145-1154. PMID: 35267136 -
Metab Brain Dis
Ginkgolide B inactivates the NLRP3 inflammasome by promoting autophagic degradation to improve learning and memory impairment in Alzheimer's disease. [Abstract]2022 Feb;37(2):329-341. PMID: 35050445 -
J Pharm Pharmacol
Anoectochilus roxburghii polysaccharide reduces D-GalN/LPS-induced acute liver injury by regulating the activation of multiple inflammasomes. [Abstract]2024 Jul 10:rgae077. PMID: 38985664 -
Mol Immunol
SNX10 promoted liver IR injury by facilitating macrophage M1 polarization via NLRP3 inflammasome activation. [Abstract]2024 Feb:166:79-86. PMID: 38271879 -
J Pharm Pharmacol
2024 Mar 4;76(3):213-223. PMID: 38215026 -
Mol Immunol
CoQ10 alleviates hepatic ischemia reperfusion injury via inhibiting NLRP3 activity and promoting Tregs infiltration. [Abstract]2023 Mar:155:7-16. PMID: 36640727 -
Parasit Vectors
A novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae regulates inflammasome activation through the TLR4-ROS-NLRP3 pathway. [Abstract]2022 Sep 23;15(1):334. PMID: 36151570 -
Int J Med Sci
Cancer Cell enters reversible quiescence through Intracellular Acidification to resist Paclitaxel Cytotoxicity. [Abstract]2020 Jun 29;17(11):1652-1664. PMID: 32669967 -
Mol Immunol
2020 Apr 13;122:28-37. PMID: 32298872 -
Toxicol Appl Pharmacol
Aloperine mitigates cigarette smoke-induced inflammation and pyroptosis by inhibiting the BRD4/NLRP3/GSDMD pathway in chronic obstructive pulmonary disease. [Abstract]2026 Feb:507:117704. PMID: 41485499 -
Immun Inflamm Dis
2023 Oct;11(10):e1043. PMID: 37904708 -
Mol Biol Rep
2025 Apr 21;52(1):407. PMID: 40257700 -
Brain Res
Molecular mechanism of HDAC6-mediated pyroptosis in neurological function recovery after cardiopulmonary resuscitation in rats. [Abstract]2024 Jul 10:149121. PMID: 38997102 -
Brain Res
Remimazolam inhibits postoperative cognitive impairment after cardiopulmonary bypass by alleviating neuroinflammation and promoting microglia M2 polarization. [Abstract]2024 Sep 1:1838:148975. PMID: 38702024 -
Exp Eye Res
miR-20a-5p alleviates diabetic retinopathy by targeting TXNIP to inhibit NLRP3 inflammasome-dependent pyroptosis. [Abstract]2026 Jun 6:270:111109. PMID: 42250589 -
Tissue Cell
Melatonin attenuates chronic obstructive pulmonary disease by suppressing NLRP3-mediated pyroptosis in alveolar macrophages. [Abstract]2025 Dec 30:99:103305. PMID: 41500094 -
Tissue Cell
Knockdown of Lcn2 alleviates pyroptosis in a neonatal rat model of necrotizing enterocolitis through IL-17A signaling pathway suppression. [Abstract]2025 Sep 22:98:103152. PMID: 41014728 -
Tissue Cell
Ling-Gui-Zhu-Gan decoction inhibits cardiomyocyte pyroptosis via the NLRP3/Caspase-1 signaling pathway. [Abstract]2024 Dec:91:102588. PMID: 39442311 -
Chin J Integr Med
Nootkatone Improves Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors by Repressing NF-κB/NLRP3-Mediated Neuroinflammation. [Abstract]2023 Jan;29(1):37-43. PMID: 36401752 -
PeerJ
Breviscapine alleviates podocyte injury by inhibiting NF-κB/NLRP3-mediated pyroptosis in diabetic nephropathy. [Abstract]2023 Feb 13:11:e14826. PMID: 36815984 -
PeerJ
Theacrine alleviates sepsis-induced acute kidney injury by repressing the activation of NLRP3/Caspase-1 inflammasome. [Abstract]2022 Oct 4:10:e14109. PMID: 36213494 -
Physiol Res
Hirudin Alleviates Early Brain Injury After Subarachnoid Hemorrhage in Rats via Regulating NLRP3 Inflammasome-Mediated Pyroptosis. [Abstract]2025 Apr 30;74(2):301-312. PMID: 40432444 -
Brain Behav
2020 Jun;10(6):e01627. PMID: 32307887 -
Shock
Hydromorphone mitigates cardiopulmonary bypass-induced acute lung injury by repressing pyroptosis of alveolar macrophages. [Abstract]2023 Jul 1;60(1):92-99. PMID: 37127893 -
J Mol Histol
The TRAF6-TXNIP-NLRP3 signaling axis regulates LPS-induced pyroptosis in glomerular podocytes. [Abstract]2026 Apr 20;57(3):142. PMID: 42010017 -
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J Mol Histol
Butyrate protects against myocardial ischemia injury and cardiomyocyte pyroptosis by inhibiting MALT1-mediated Nrf2 ubiquitination and degradation. [Abstract]2025 Aug 8;56(4):261. PMID: 40779176 -
Prostaglandins Other Lipid Mediat
Protective role of TRPM7 knockdown in ulcerative colitis via blocking NLRP3 inflammasome-mediated pyroptosis. [Abstract]2024 Sep 9:106904. PMID: 39260818 -
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Biochem Biophys Res Commun
Complement-coupled erythrocyte platform for rapid enrichment of candidate NLRP3 modulators. [Abstract]2026 Jun 9:829:154128. PMID: 42320295 -
Biomed Rep
Spermidine mitigates lipopolysaccharide-induced acute lung injury by enhancing autophagic flux. [Abstract]2025 Sep 25;23(6):183. PMID: 41089344 -
Am J Reprod Immunol
ATP/P2X4 Regulates Inflammation and Oxidative Stress in Endometriosis Through NLRP3 Inflammasome-Dependent Mechanisms. [Abstract]2025 Aug;94(2):e70132. PMID: 40815040 -
Clin Cosmet Investig Dermatol
Effect of Chloroquine on Type 2 Inflammatory Response in MC903-Induced Atopic Dermatitis Mice. [Abstract]2024 May 14:17:1093-1105. PMID: 38765196 -
Biochem Biophys Res Commun
Formononetin ameliorates myocardial ischemia/reperfusion injury in rats by suppressing the ROS-TXNIP-NLRP3 pathway. [Abstract]2020 May 7;525(3):759-766. PMID: 32145915 -
Cytotechnology
Taraxasterol mediated autophagy inhibition in pancreatic encephalopathy involves its regulation on L1 cell adhesion molecule. [Abstract]2025 Apr;77(2):72. PMID: 40051886 -
Exp Ther Med
Dexmedetomidine alleviates inflammation in neuropathic pain by suppressing NLRP3 via Nrf2 activation. [Abstract]2021 Oct;22(4):1046. PMID: 34434260 -
Open Med
2026 Apr 9;21(1):20261397. PMID: 41970698 -
Rejuvenation Res
BICDL1 Mediates Pyroptosis to Promote Breast Cancer Cell Proliferation, Inhibition, and Migration. [Abstract]2025 Sep 15. PMID: 40944522 -
J Toxicol Sci
Dexmedetomidine protects against Ropivacaine-induced neuronal pyroptosis via the Nrf2/HO-1 pathway. [Abstract]2023;48(3):139-148. PMID: 36858639 -
J Cardiothorac Surg
Interval training suppresses nod-like receptor protein 3 inflammasome activation to improve cardiac function in myocardial infarction rats by hindering the activation of the transforming growth factor-β1 pathway. [Abstract]2024 May 10;19(1):283. PMID: 38730417 -
Biosci Biotechnol Biochem
Mito-tempo alleviates ox-LDL-provoked foam cell formation by regulating Nrf2/NLRP3 signaling. [Abstract]2024 May 8:zbae058. PMID: 38719485 -
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Open Res Eur
Screening Actinomycetes extracts for antimicrobial compounds against methicillin-resistant Staphylococcus aureus and helper-compounds against aminoglycoside-resistant E. coli. [Abstract]2025 Aug 11:5:110. PMID: 40931753 -
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Biomed Pharmacother
Celastrol exerts antiarrhythmic effects in chronic heart failure via NLRP3/Caspase-1/IL-1β signaling pathway. [Abstract]2024 Jul 12:177:117121. PMID: 39002443
Nigericin purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Jul 12:177:117121. [Abstract]
Nigericin (10 μM; 24 h) significantly upregulated the protein expression of NLRP3, Caspase-1, ASC, IL-1β, and IL-18 in hypoxia-treated H9c2 cells, reversing the inhibitory effects of Celastrol.
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Environ Toxicol
Naringenin facilitates M2 macrophage polarization after myocardial ischemia-reperfusion by promoting nuclear translocation of transcription factor EB and inhibiting the NLRP3 inflammasome pathway. [Abstract]2023 Jun;38(6):1405-1419. PMID: 36988289
Nigericin purchased from MedChemExpress. Usage Cited in: Environ Toxicol. 2023 Jun;38(6):1405-1419. [Abstract]
Nigericin (1.38mM; 2 μg/2 μL; 10 min) signifcantly increases the expression of IL-1β, IL-18, and GSDMD N-terminal in rats
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Oxid Med Cell Longev
P2X7R Mediates the Synergistic Effect of ATP and MSU Crystals to Induce Acute Gouty Arthritis. [Abstract]2023 Jan 12:2023:3317307. PMID: 36686377 -
Biomed Pharmacother
Dendrobium officinale polysaccharides attenuate uropathogenic Escherichia coli (UPEC)-induced pyroptosis in macrophage cells. [Abstract]2022 Jul;151:113098. PMID: 35594714 -
Oxid Med Cell Longev
HBO Alleviates Neural Stem Cell Pyroptosis via lncRNA-H19/miR-423-5p/NLRP3 Axis and Improves Neurogenesis after Oxygen Glucose Deprivation. [Abstract]2022 Feb 7;2022:9030771. PMID: 35178162 -
Aging (Albany NY)
2021 Aug 25;13(16):20534-20551. PMID: 34432650 -
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Oncotarget
miR-352 participates in the regulation of trypsinogen activation in pancreatic acinar cells by influencing the function of autophagic lysosomes. [Abstract]2018 Jan 13;9(13):10868-10879. PMID: 29541382
Solvente y solubilidad
Ethanol : ≥ 33.33 mg/mL (45.97 mM)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.45 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (3.45 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.
Please enter the basic information of animal experiments:
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-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (283 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Zotova L, et al. Novel components of an active mitochondrial K(+)/H(+) exchange. J Biol Chem. 2010 May 7;285(19):14399-414. [Content Brief]
[2]. Mariathasan S, et al.Cryopyrin activates the inflammasome in response to toxins and ATP.Nature. 2006 Mar 9;440(7081):228-32. [Content Brief]
[3]. Bissinger R, et al. Triggering of Suicidal Erythrocyte Death by the Antibiotic Ionophore Nigericin. Basic Clin Pharmacol Toxicol. 2016 May;118(5):381-9. [Content Brief]
[4]. Xiaoli Zhu, et al. Nigericin is effective against multidrug resistant gram-positive bacteria, persisters, and biofilms. Front Cell Infect Microbiol. 2022 Dec 20:12:1055929. [Content Brief]
[5]. Guanzhuang Gao, et al. Evidence of nigericin as a potential therapeutic candidate for cancers: A review. Biomed Pharmacother. 2021 May:137:111262. [Content Brief]
[6]. Lisha Wu, et al. Nigericin Boosts Anti-Tumor Immune Response via Inducing Pyroptosis in Triple-Negative Breast Cancer. Cancers (Basel). 2023 Jun 16;15(12):3221. [Content Brief]
[7]. Juan Sebastian Yakisich, et al. Nigericin decreases the viability of multidrug-resistant cancer cells and lung tumorspheres and potentiates the effects of cardiac glycosides. Tumour Biol.2017 Mar;39(3):1010428317694310. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 1.3794 mL | 6.8969 mL | 13.7939 mL | 34.4847 mL |
| 5 mM | 0.2759 mL | 1.3794 mL | 2.7588 mL | 6.8969 mL | |
| 10 mM | 0.1379 mL | 0.6897 mL | 1.3794 mL | 3.4485 mL | |
| 15 mM | 0.0920 mL | 0.4598 mL | 0.9196 mL | 2.2990 mL | |
| 20 mM | 0.0690 mL | 0.3448 mL | 0.6897 mL | 1.7242 mL | |
| 25 mM | 0.0552 mL | 0.2759 mL | 0.5518 mL | 1.3794 mL | |
| 30 mM | 0.0460 mL | 0.2299 mL | 0.4598 mL | 1.1495 mL | |
| 40 mM | 0.0345 mL | 0.1724 mL | 0.3448 mL | 0.8621 mL |
Nigericin Related Classifications
HY-127019 Related Classifications
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