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Referencia número: HY-10617AS1

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Rucaparib-d₃

(Synonyms: AG014699-d₃; PF-01367338-d₃)

Rucaparib-d₃ (AG014699-d₃) is the deuterated -labeled Rucaparib (HY-10617A). Rucaparib (AG014699) is an orally active, potent inhibitor of PARP proteins (PARP-1, PARP-2 and PARP-3) with a K_i of 1.4 nM for PARP1. Rucaparib is a modest hexose-6-phosphate dehydrogenase (H6PD) inhibitor. Rucaparib has the potential for castration-resistant prostate cancer (CRPC) research.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 2271225-13-7
Fòrmula: C₁₉H₁₅D₃FN₃O
Peso molecular:326.38

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Rucaparib-d₃ Chemical Structure

No. CAS: 2271225-13-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
- In Vivo
- Aplicación
Chemical Information
Pureza y Documentación
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas PARP :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Animal Model:

Female CD-1 nude mice aged 10-12 weeks with Capan-1 cells^[2]
Dosage:

10 mg/kg for i.p. or 50, 150 mg/kg for p.o.
Administration:

IP or PO
Result:

Significantly inhibited the growth of the tumor.

Aplicación

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

No. CAS 2271225-13-7
Unlabeled Cas 283173-50-2
Peso molecular 326.38
Fòrmula C₁₉H₁₅D₃FN₃O
SMILES

O=C1C2=C3C(CCN1)=C(C4=CC=C(C=C4)CNC([2H])([2H])[2H])NC3=CC(F)=C2
Synonyms

AG014699-d₃; PF-01367338-d₃
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.