TP-1287
Based on 1 Customer Validation
TP-1287, a prodrug of Alvocidib (HY-10005), is an orally active CDK9 inhibitor.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 95.93%
- No. CAS: 2044686-42-0
- Fòrmula: C21H21ClNO8P
- Peso molecular:481.82
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Almacenamiento:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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CDK9 |
TP-1287 is highly soluble over a broader pH range than Alvocidib (HY-10005) and is efficiently metabolized to the parent compound in vivo, following oral administration[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:RPMI-8226 xenograft model for multiple myeloma[1]
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Dosage:2.5, 7.5, and 15 mg/kg
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Administration:Oral
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Result:Achieved tumor growth inhibition (%TGI) of 56.0, 76.6, and 93.9% at doses of 2.5, 7.5, and 15 mg/kg, respectively.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 2044686-42-0
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Appearance Solid
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Peso molecular 481.82
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Fòrmula C21H21ClNO8P
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Color Light yellow to yellow
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SMILES
O=P(O)(O)OC1=CC(O)=C(C(C=C(C2=C(C=CC=C2)Cl)O3)=O)C3=C1[C@@H]4[C@@H](CN(CC4)C)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvente y solubilidad
Methanol : 125 mg/mL (259.43 mM; Need ultrasonic)
DMSO : 10 mg/mL (20.75 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / Methanol | 1 mM | 2.0755 mL | 10.3773 mL | 20.7546 mL | 51.8866 mL |
| 5 mM | 0.4151 mL | 2.0755 mL | 4.1509 mL | 10.3773 mL | |
| 10 mM | 0.2075 mL | 1.0377 mL | 2.0755 mL | 5.1887 mL | |
| 15 mM | 0.1384 mL | 0.6918 mL | 1.3836 mL | 3.4591 mL | |
| 20 mM | 0.1038 mL | 0.5189 mL | 1.0377 mL | 2.5943 mL | |
| Methanol | 25 mM | 0.0830 mL | 0.4151 mL | 0.8302 mL | 2.0755 mL |
| 30 mM | 0.0692 mL | 0.3459 mL | 0.6918 mL | 1.7296 mL | |
| 40 mM | 0.0519 mL | 0.2594 mL | 0.5189 mL | 1.2972 mL | |
| 50 mM | 0.0415 mL | 0.2075 mL | 0.4151 mL | 1.0377 mL | |
| 60 mM | 0.0346 mL | 0.1730 mL | 0.3459 mL | 0.8648 mL | |
| 80 mM | 0.0259 mL | 0.1297 mL | 0.2594 mL | 0.6486 mL | |
| 100 mM | 0.0208 mL | 0.1038 mL | 0.2075 mL | 0.5189 mL |
TP-1287 Related Classifications
HY-153260 Related Classifications
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