Casr - calcium-sensing receptor Gene

Also Known as CaR; Gprc2a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12374

About Casr

Chromosome 16: 36,314,058-36,382,503 reverse strand.GRCm39:CM001009.3

This gene has 4 transcripts (splice variants), 203 orthologues, 129 paralogues and is associated with 43 phenotypes. Biased expression in kidney adult (RPKM 6.6) and mammary gland adult (RPKM .5).

Summary

Predicted to enable several functions, including Integrin binding activity; protein homodimerization activity; and transmembrane transporter binding activity. Acts upstream of or within positive regulation of ATPase activity; positive regulation of gene expression; and regulation of calcium ion transport. Predicted to be located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and neuronal cell body. Predicted to be integral component of plasma membrane. Is expressed in several structures, including branchial pouch; central nervous system; lung; metanephros; and superior cervical ganglion. Used to study autosomal dominant hypocalcemia 1; familial hypocalciuric hypercalcemia 1; and hyperparathyroidism. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant hypocalcemia (multiple); hypercalcemia (multiple); hyperparathyroidism (multiple); idiopathic generalized epilepsy 8; and nephrolithiasis (multiple). Orthologous to human CaSR (calcium sensing receptor). [provided by Alliance of Genome Resources, Apr 2022]

Casr Products (1)

mRNA Protein Name
NM_013803.3 NP_038831.2 extracellular calcium-sensing receptor precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of ATP-dependent activity IDA
IDA: Inferred from direct assay
17823248 MGI
acts upstream of or within positive regulation of ATP-dependent activity IMP
IMP: Inferred from mutant phenotype
17823248 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
18794335 MGI
acts upstream of or within regulation of calcium ion transport IDA
IDA: Inferred from direct assay
17823248 MGI
involved in regulation of presynaptic membrane potential EXP
EXP: Inferred from Experiment
19005071 MGI
involved in regulation of presynaptic membrane potential IDA
IDA: Inferred from direct assay
19005071 MGI
involved in regulation of presynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
19005071 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
19005071 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
19005071 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
19005071 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casr Protein Structure

PBP1_CaSR

PBP1_CaSR: cd06364 (32 - 529)

NCD3G

NCD3G: pfam07562 (537 - 590)

7tmC_CaSR

7tmC_CaSR: cd15282 (610 - 861)

7tmC_CaSR

7tmC_CaSR: cd15282 (610 - 635)

7tmC_CaSR

7tmC_CaSR: cd15282 (647 - 668)

7tmC_CaSR

7tmC_CaSR: cd15282 (677 - 701)

7tmC_CaSR

7tmC_CaSR: cd15282 (725 - 741)

7tmC_CaSR

7tmC_CaSR: cd15282 (768 - 794)

7tmC_CaSR

7tmC_CaSR: cd15282 (802 - 825)

7tmC_CaSR

7tmC_CaSR: cd15282 (830 - 855)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1079 a.a.
Protein Preferred Names Protein Names

extracellular calcium-sensing receptor

  • G protein-coupled receptor, family C, group 2, member A

  • PCaR1

  • cation sensing receptor

  • parathyroid cell calcium-sensing receptor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-70037 Cinacalcet Agonist 99.93% Yes
HY-70037A Cinacalcet hydrochloride Agonist 99.98% Yes
HY-W017018 L-Ornithine hydrochloride Activator 99.91% Unkown
HY-P1955A Etelcalcetide hydrochloride Activator 99.80% Unkown
HY-17397 Strontium Ranelate Activator 99.30% Unkown
HY-17613 Evocalcet Activator 99.28% Unkown
HY-109106A Upacicalcet sodium Agonist 99.91% Unkown
HY-P1955 Etelcalcetide Activator / Unkown
HY-109106 Upacicalcet Agonist / Unkown

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-14401 Encaleret Antagonist 99.88% Phase 3
HY-10007 NPS-2143 Antagonist 99.94% Phase 2
HY-10167A Tecalcet Hydrochloride Modulator 99.43% Phase 2
HY-15105 SB-423562 Antagonist 99.62% Phase 2
HY-14752 Ronacaleret Antagonist / Phase 2
HY-177303 AXT-914 Inhibitor 98.83% Phase 1

Pre-clinical Phase

Bioactive Molecules (50)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139201A Poly-D-lysine hydrobromide (MW 70000-150000) Agonist 99.86% Unkown
HY-139201 Poly-D-lysine hydrobromide (MW 30000-70000) Agonist / Unkown
HY-W017018S4 L-Ornithine-d7 hydrochloride Activator 99.90% Unkown
HY-112171 γ-L-Glutamyl-L-alanine Modulator 98.0% Unkown
HY-12557 γ-Glutamylvaline Agonist 99.94% Unkown
HY-W017018S2 L-Ornithine-1,2,3,4,5-13C5 hydrochloride Activator 99.88% Unkown
HY-10171 NPS-2143 hydrochloride Antagonist 99.98% Unkown
HY-103320A Calhex 231 hydrochloride Inhibitor 99.81% Unkown
HY-N0546 Ligustroflavone Antagonist 99.90% Unkown
HY-139201B Poly-D-lysine hydrobromide (MW 84000) Agonist / Unkown
HY-W017018S L-Ornithine-d6 hydrochloride Activator 99.2% Unkown
HY-11095 NPS 2390 Inhibitor 99.90% Unkown
HY-122819 Calindol hydrochloride Agonist 99.64% Unkown
HY-W017018S5 L-Ornithine-15N2 hydrochloride Activator 98.90% Unkown
HY-121584 Lycoperodine-1 Agonist 99.82% Unkown
HY-139201D Poly-D-lysine hydrobromide (MW 4000-15000) / Unkown
HY-P4376A Gamma-Glu-Abu TFA Activator 96.83% Unkown
HY-W843885 H-Glu-Thr-OH Activator 98.63% Unkown
HY-103320B (1R,2R)-Calhex 231 hydrochloride Control 98.45% Unkown
HY-W017018S3 L-Ornithine-d2 hydrochloride Activator 99.94% Unkown
HY-117851 AC-265347 Agonist 99.97% Unkown
HY-112171R γ-L-Glutamyl-L-alanine (Standard) Modulator 99.29% Unkown
HY-139201E Poly-D-lysine hydrobromide (MW 150000-300000) Agonist / Unkown
HY-50713 Calcium-Sensing receptor antagonist I Antagonist 98.95% Unkown
HY-107773 GSK3004774 Agonist 99.09% Unkown
HY-15104 Ronacaleret hydrochloride Antagonist 99.81% Unkown
HY-W017018B L-Ornithine monohydrochloride,suitable for cell culture Activator 99.73% Unkown
HY-139201H Poly-D-lysine hydrobromide (MW ≥300000) Activator / Unkown
HY-70037AS Cinacalcet-d3 hydrochloride Agonist 97.63% Unkown
HY-P11668 Gosicalcetide Agonist / Unkown
HY-P4376B Gamma-Glu-Abu acetate Activator / Unkown
HY-14401B Encaleret sodium Antagonist / Unkown
HY-15106 SB-423557 Antagonist / Unkown
HY-103320 Calhex 231 Antagonist / Unkown
HY-W777503 Calindol hydrochloride-13C,D2 / Unkown
HY-139201C Poly-D-lysine hydrobromide (MW 1000-5000) Activator / Unkown
HY-P4376 Gamma-Glu-Abu Activator / Unkown
HY-179475 KP-2067 Agonist / Unkown
HY-10167 Tecalcet Modulator / Unkown
HY-153258 CaSR antagonist-1 Antagonist / Unkown
HY-70037S Cinacalcet-d3 Agonist / Unkown
HY-109106B (Rac)-Upacicalcet 95.0% Unkown
HY-P11832 CaSR agonist peptide-1 Agonist / Unkown
HY-17613S Evocalcet-d4 Activator / Unkown
HY-15105A SB-423562 hydrochloride Antagonist / Unkown
HY-W017018S1 L-Ornithine-1,2-13C2 hydrochloride Activator / Unkown
HY-171446 TAK-075 Antagonist / Unkown
HY-161113 Z8554052021 Activator / Unkown
HY-182543 NPS-467 Activator / Unkown
HY-W653978 Cinacalcet-d4 hydrochloride Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Casr NCBI NCBI:846