Casr - calcium-sensing receptor Gene

Also known as CaR; Gprc2a

About Casr

Summary

Predicted to enable several functions, including Integrin binding activity; protein homodimerization activity; and transmembrane transporter binding activity. Acts upstream of or within positive regulation of ATPase activity; positive regulation of gene expression; and regulation of calcium ion transport. Predicted to be located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and neuronal cell body. Predicted to be integral component of plasma membrane. Is expressed in several structures, including branchial pouch; central nervous system; lung; metanephros; and superior cervical ganglion. Used to study autosomal dominant hypocalcemia 1; familial hypocalciuric hypercalcemia 1; and hyperparathyroidism. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant hypocalcemia (multiple); hypercalcemia (multiple); hyperparathyroidism (multiple); idiopathic generalized epilepsy 8; and nephrolithiasis (multiple). Orthologous to human CaSR (calcium sensing receptor). [provided by Alliance of Genome Resources, Apr 2022]