2. Gene
  3. Hdac5 - histone deacetylase 5 Gene

Hdac5 - histone deacetylase 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as HD5; Hdac4; mHDA1; mKIAA0600

Gene ID: 15184 | Gene type: protein coding

About Hdac5

Chromosome 11: 102,085,258-102,120,992 reverse strand.GRCm39:CM001004.3

This gene has 20 transcripts (splice variants), 194 orthologues, 10 paralogues and is associated with 1 phenotype. Ubiquitous expression in lung adult (RPKM 2.5), adrenal adult (RPKM 19.) and 28 other tissues.

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; transcription corepressor activity; and transcription corepressor binding activity. Involved in several processes, including cellular response to fluid shear stress; positive regulation of cell population proliferation; and regulation of myotube differentiation. Acts upstream of or within several processes, including negative regulation of macromolecule metabolic process; negative regulation of osteoblast differentiation; and osteoblast development. Located in several cellular components, including axonal growth cone; chromatin; and nuclear body. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including central nervous system; early embryo; head bone; sensory organ; and upper arm. Orthologous to human HDAC5 (histone deacetylase 5). [provided by Alliance of Genome Resources, Apr 2022]

Hdac5 Products(18)

mRNA Protein Name
NM_010412.4 NP_034542.3 histone deacetylase 5 isoform 2
NM_001284250.2 NP_001271179.1 histone deacetylase 5 isoform 5
NM_001405239.1 NP_001392168.1 histone deacetylase 5 isoform 11
NM_001405237.1 NP_001392166.1 histone deacetylase 5 isoform 10
NM_001405234.1 NP_001392163.1 histone deacetylase 5 isoform 8
NM_001284248.2 NP_001271177.1 histone deacetylase 5 isoform 3
NM_001405241.1 NP_001392170.1 histone deacetylase 5 isoform 13
NM_001405233.1 NP_001392162.1 histone deacetylase 5 isoform 7
NM_001405242.1 NP_001392171.1 histone deacetylase 5 isoform 13
NM_001405232.1 NP_001392161.1 histone deacetylase 5 isoform 6
NM_001405238.1 NP_001392167.1 histone deacetylase 5 isoform 11
NM_001361596.2 NP_001348525.1 histone deacetylase 5 isoform 4
NM_001405235.1 NP_001392164.1 histone deacetylase 5 isoform 9
NM_001405236.1 NP_001392165.1 histone deacetylase 5 isoform 9
NM_001284249.2 NP_001271178.1 histone deacetylase 5 isoform 4
NM_001405240.1 NP_001392169.1 histone deacetylase 5 isoform 12
NM_001405244.1 NP_001392173.1 histone deacetylase 5 isoform 14
NM_001077696.2 NP_001071164.1 histone deacetylase 5 isoform 1

Hdac5 Protein Structure

ClassIIa_HDAC_Gln-rich-N

ClassIIa_HDAC_Gln-rich-N: cl25407 (67 - 154)

HDAC5

HDAC5: cd10007 (670 - 1089)

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  • 1114 a.a.
Protein Preferred Names Protein Names

histone deacetylase 5

histone deacetylase 4

histone deacetylase mHDA1

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13322 Pracinostat Inhibitor 99.82% Yes
Clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Phase
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842 Givinostat Inhibitor 98.05% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor / Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 98.28% Phase 2
HY-16012A Domatinostat Inhibitor 99.43% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-10223 CUDC-101 Inhibitor 99.19% Phase 1
Pre-clinical Phase
Bioactive Molecules (26)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18361 TMP195 Inhibitor 99.57% Unkown
HY-18998 LMK-235 Inhibitor 99.61% Unkown
HY-18360 TMP269 Inhibitor 98.05% Unkown
HY-13428 Tubacin Inhibitor 95.50% Unkown
HY-16699 Nexturastat A Inhibitor 99.03% Unkown
HY-112719 BRD 4354 Inhibitor 99.66% Unkown
HY-115475 SW-100 Inhibitor 99.59% Unkown
HY-119939 CHDI-390576 Inhibitor 98.07% Unkown
HY-143248 KR-39038 Inhibitor 99.48% Unkown
HY-126330 SS-208 Inhibitor 99.00% Unkown
HY-149285 NT160 Inhibitor 99.58% Unkown
HY-112719B BRD 4354 ditrifluoroacetate Inhibitor 98.06% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-150109 Purinostat mesylate Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-146351 HDAC-IN-38 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-149208 HDAC-IN-53 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor / Unkown
HY-157740 XSJ-10 Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac5 NCBI NCBI:10014