Hdac5 - histone deacetylase 5 Gene

Also Known as HD5; Hdac4; mHDA1; mKIAA0600

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15184

About Hdac5

Chromosome 11: 102,085,258-102,120,992 reverse strand.GRCm39:CM001004.3

This gene has 20 transcripts (splice variants), 194 orthologues, 10 paralogues and is associated with 1 phenotype. Ubiquitous expression in lung adult (RPKM 2.5), adrenal adult (RPKM 19.) and 28 other tissues.

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; transcription corepressor activity; and transcription corepressor binding activity. Involved in several processes, including cellular response to fluid shear stress; positive regulation of cell population proliferation; and regulation of myotube differentiation. Acts upstream of or within several processes, including negative regulation of macromolecule metabolic process; negative regulation of osteoblast differentiation; and osteoblast development. Located in several cellular components, including axonal growth cone; chromatin; and nuclear body. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including central nervous system; early embryo; head bone; sensory organ; and upper arm. Orthologous to human HDAC5 (histone deacetylase 5). [provided by Alliance of Genome Resources, Apr 2022]

Hdac5 Products (18)

mRNA Protein Name
NM_010412.4 NP_034542.3 histone deacetylase 5 isoform 2
NM_001284250.2 NP_001271179.1 histone deacetylase 5 isoform 5
NM_001405239.1 NP_001392168.1 histone deacetylase 5 isoform 11
NM_001405237.1 NP_001392166.1 histone deacetylase 5 isoform 10
NM_001405234.1 NP_001392163.1 histone deacetylase 5 isoform 8
NM_001284248.2 NP_001271177.1 histone deacetylase 5 isoform 3
NM_001405241.1 NP_001392170.1 histone deacetylase 5 isoform 13
NM_001405233.1 NP_001392162.1 histone deacetylase 5 isoform 7
NM_001405242.1 NP_001392171.1 histone deacetylase 5 isoform 13
NM_001405232.1 NP_001392161.1 histone deacetylase 5 isoform 6
NM_001405238.1 NP_001392167.1 histone deacetylase 5 isoform 11
NM_001361596.2 NP_001348525.1 histone deacetylase 5 isoform 4
NM_001405235.1 NP_001392164.1 histone deacetylase 5 isoform 9
NM_001405236.1 NP_001392165.1 histone deacetylase 5 isoform 9
NM_001284249.2 NP_001271178.1 histone deacetylase 5 isoform 4
NM_001405240.1 NP_001392169.1 histone deacetylase 5 isoform 12
NM_001405244.1 NP_001392173.1 histone deacetylase 5 isoform 14
NM_001077696.2 NP_001071164.1 histone deacetylase 5 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
10748098 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
20181743 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20181743 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
20123967 MGI
enables histone deacetylase activity IDA
IDA: Inferred from direct assay
10640276 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10640276 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
17468767 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
10640276 MGI
enables transcription corepressor activity IGI
IGI: Inferred from genetic interaction
15990875 MGI
enables transcription corepressor binding IPI
IPI: Inferred from physical interaction
12007404 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to fluid shear stress IDA
IDA: Inferred from direct assay
20181743 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
15367668 MGI
acts upstream of or within multicellular organismal response to stress IMP
IMP: Inferred from mutant phenotype
17988634 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16260608 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23926128 MGI
acts upstream of or within negative regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
15990875 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10640276 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15601857 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20181743 MGI
acts upstream of or within osteoblast development IMP
IMP: Inferred from mutant phenotype
15990875 MGI
acts upstream of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
15990875 MGI
involved in positive regulation of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
20123967 MGI
involved in positive regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
20123967 MGI
involved in regulation of myotube differentiation IDA
IDA: Inferred from direct assay
17468767 MGI
acts upstream of or within regulation of skeletal muscle fiber development IGI
IGI: Inferred from genetic interaction
17786239 MGI
acts upstream of or within regulation of skeletal muscle fiber differentiation IGI
IGI: Inferred from genetic interaction
17786239 MGI
involved in renal tubule morphogenesis IMP
IMP: Inferred from mutant phenotype
20181743 MGI
acts upstream of or within response to cocaine IDA
IDA: Inferred from direct assay
17988634 MGI
acts upstream of or within response to cocaine IMP
IMP: Inferred from mutant phenotype
17988634 MGI
Cellular Component GO Annotation Evidence References Source
part of RNA polymerase II transcription repressor complex IDA
IDA: Inferred from direct assay
12007404 MGI
located in axonal growth cone IDA
IDA: Inferred from direct assay
26157139 MGI
located in chromatin IDA
IDA: Inferred from direct assay
12007404 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11081517 MGI
located in cytosol IDA
IDA: Inferred from direct assay
18198354 MGI
located in nuclear body IDA
IDA: Inferred from direct assay
11641275 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
10640276 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11081517 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hdac5 Protein Structure

ClassIIa_HDAC_Gln-rich-N

ClassIIa_HDAC_Gln-rich-N: cl25407 (67 - 154)

HDAC5

HDAC5: cd10007 (670 - 1089)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1114 a.a.
Protein Preferred Names Protein Names

histone deacetylase 5

  • histone deacetylase 4

  • histone deacetylase mHDA1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14842 Givinostat Inhibitor 98.67% Yes
HY-13322 Pracinostat Inhibitor 99.80% Yes
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 99.63% Yes
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Yes

Clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Phase 2
HY-16012A Domatinostat Inhibitor 99.34% Phase 2
HY-13432 Nanatinostat Inhibitor 99.67% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-13432A Nanatinostat TFA Inhibitor / Phase 2
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1

Pre-clinical Phase

Bioactive Molecules (43)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18361 TMP195 Inhibitor 99.82% Unkown
HY-13428 Tubacin Inhibitor 97.11% Unkown
HY-18998 LMK-235 Inhibitor 99.61% Unkown
HY-18360 TMP269 Inhibitor 98.16% Unkown
HY-16699 Nexturastat A Inhibitor 98.69% Unkown
HY-119939 CHDI-390576 Inhibitor 98.10% Unkown
HY-115475 SW-100 Inhibitor 99.93% Unkown
HY-112719 BRD 4354 Inhibitor 98.10% Unkown
HY-126330 SS-208 Inhibitor 99.00% Unkown
HY-150109 Purinostat mesylate Inhibitor 99.45% Unkown
HY-135714 Bavarostat Inhibitor 99.51% Unkown
HY-143248 KR-39038 Inhibitor 99.68% Unkown
HY-149285 NT160 Inhibitor 99.58% Unkown
HY-181126 G194-0712 Activator 99.82% Unkown
HY-112719B BRD 4354 ditrifluoroacetate Inhibitor 98.06% Unkown
HY-148624 CHDI-00484077 Inhibitor 98.38% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-149208 HDAC-IN-53 Inhibitor 95.73% Unkown
HY-P10462A SAP15 acetate Inhibitor 98.04% Unkown
HY-157740 XSJ-10 Inhibitor 95.16% Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-183560 HDAC6-IN-82 Inhibitor / Unkown
HY-15433B Quisinostat hydrochloride Inhibitor / Unkown
HY-179019 HDAC-IN-94 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor 98.71% Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-176733 HDAC6-IN-61 Inhibitor / Unkown
HY-176868 Rodin-C Inhibitor / Unkown
HY-146351 HDAC-IN-38 Inhibitor / Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-184203 SM-06-09 Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-P10462 SAP15 Inhibitor / Unkown
HY-175030 TNI-97 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-181579 HDAC6-IN-74 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac5 NCBI NCBI:10014