Casr - calcium-sensing receptor Gene

Also Known as PCaR1; RaKCaR

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24247

About Casr

Primary_assembly 11: 64,235,251-64,304,811 forward strand.mRatBN7.2:CM026984.1

This gene has 2 transcripts (splice variants), 203 orthologues, 98 paralogues and is associated with 39 phenotypes. Restricted expression toward (RPKM 159.2).

Summary

Enables Integrin binding activity; protein kinase binding activity; and transmembrane transporter binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; blood vessel diameter maintenance; and cellular chemical homeostasis. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and neuronal cell body. Used to study cardiomyopathy. Biomarker of atherosclerosis; myocardial infarction; and pulmonary hypertension. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant hypocalcemia (multiple); hypercalcemia (multiple); hyperparathyroidism (multiple); idiopathic generalized epilepsy 8; and nephrolithiasis (multiple). Orthologous to human CaSR (calcium sensing receptor). [provided by Alliance of Genome Resources, Apr 2022]

Casr Products (2)

mRNA Protein Name
NM_016996.2 NP_058692.1 extracellular calcium-sensing receptor precursor
NM_001309638.1 NP_001296567.1 extracellular calcium-sensing receptor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables integrin binding IPI
IPI: Inferred from physical interaction
21969374 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
20383739 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
21084311 RGD
Biological Process GO Annotation Evidence References Source
involved in JNK cascade IMP
IMP: Inferred from mutant phenotype
15084499 RGD
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
22192592 RGD
involved in bile acid secretion IDA
IDA: Inferred from direct assay
11071898 RGD
involved in branching morphogenesis of an epithelial tube IMP
IMP: Inferred from mutant phenotype
20117086 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
21146545 RGD
involved in cellular response to hepatocyte growth factor stimulus IEP
IEP: Inferred from expression pattern
21088907 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
21073657 RGD
involved in cellular response to low-density lipoprotein particle stimulus IEP
IEP: Inferred from expression pattern
22083546 RGD
involved in cellular response to peptide IEP
IEP: Inferred from expression pattern
22678567 RGD
involved in cellular response to vitamin D IEP
IEP: Inferred from expression pattern
21940515 RGD
involved in chloride transmembrane transport IDA
IDA: Inferred from direct assay
7816802 RGD
involved in detection of calcium ion IDA
IDA: Inferred from direct assay
7816802 RGD
involved in fat pad development IEP
IEP: Inferred from expression pattern
21940515 RGD
involved in intracellular calcium ion homeostasis IDA
IDA: Inferred from direct assay
12065312 RGD
involved in ossification IMP
IMP: Inferred from mutant phenotype
15084499 RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
22192592 RGD
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
22192592 RGD
involved in positive regulation of calcium ion import IMP
IMP: Inferred from mutant phenotype
22098336 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12700162 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
22566534 RGD
involved in positive regulation of positive chemotaxis IMP
IMP: Inferred from mutant phenotype
20117086 RGD
involved in positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
22098336 RGD
involved in response to calcium ion IEP
IEP: Inferred from expression pattern
20431039 RGD
involved in response to fibroblast growth factor IEP
IEP: Inferred from expression pattern
20431039 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
21488219 RGD
involved in response to metal ion IEP
IEP: Inferred from expression pattern
22312704 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
19092814 RGD
involved in vasodilation IMP
IMP: Inferred from mutant phenotype
15084499 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
22517767 RGD
located in axon IDA
IDA: Inferred from direct assay
22517767 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
7724534 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
22517767 RGD
located in cell surface IDA
IDA: Inferred from direct assay
21969374 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
22517767 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
20052292 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casr Protein Structure

PBP1_CaSR

PBP1_CaSR: cd06364 (32 - 529)

NCD3G

NCD3G: pfam07562 (537 - 590)

7tmC_CaSR

7tmC_CaSR: cd15282 (610 - 861)

7tmC_CaSR

7tmC_CaSR: cd15282 (610 - 635)

7tmC_CaSR

7tmC_CaSR: cd15282 (647 - 668)

7tmC_CaSR

7tmC_CaSR: cd15282 (677 - 701)

7tmC_CaSR

7tmC_CaSR: cd15282 (725 - 741)

7tmC_CaSR

7tmC_CaSR: cd15282 (768 - 794)

7tmC_CaSR

7tmC_CaSR: cd15282 (802 - 825)

7tmC_CaSR

7tmC_CaSR: cd15282 (830 - 855)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1079 a.a.
Protein Preferred Names Protein Names

extracellular calcium-sensing receptor

  • Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism)

  • parathyroid Cell calcium-sensing receptor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-70037 Cinacalcet Agonist 99.93% Yes
HY-70037A Cinacalcet hydrochloride Agonist 99.98% Yes
HY-W017018 L-Ornithine hydrochloride Activator 99.91% Unkown
HY-P1955A Etelcalcetide hydrochloride Activator 99.80% Unkown
HY-17397 Strontium Ranelate Activator 99.30% Unkown
HY-17613 Evocalcet Activator 99.28% Unkown
HY-109106A Upacicalcet sodium Agonist 99.91% Unkown
HY-P1955 Etelcalcetide Activator / Unkown
HY-109106 Upacicalcet Agonist / Unkown

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-14401 Encaleret Antagonist 99.88% Phase 3
HY-10007 NPS-2143 Antagonist 99.94% Phase 2
HY-10167A Tecalcet Hydrochloride Modulator 99.43% Phase 2
HY-15105 SB-423562 Antagonist 99.62% Phase 2
HY-14752 Ronacaleret Antagonist / Phase 2
HY-177303 AXT-914 Inhibitor 98.83% Phase 1

Pre-clinical Phase

Bioactive Molecules (50)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139201A Poly-D-lysine hydrobromide (MW 70000-150000) Agonist 99.86% Unkown
HY-139201 Poly-D-lysine hydrobromide (MW 30000-70000) Agonist / Unkown
HY-W017018S4 L-Ornithine-d7 hydrochloride Activator 99.90% Unkown
HY-112171 γ-L-Glutamyl-L-alanine Modulator 98.0% Unkown
HY-12557 γ-Glutamylvaline Agonist 99.94% Unkown
HY-W017018S2 L-Ornithine-1,2,3,4,5-13C5 hydrochloride Activator 99.88% Unkown
HY-10171 NPS-2143 hydrochloride Antagonist 99.98% Unkown
HY-103320A Calhex 231 hydrochloride Inhibitor 99.81% Unkown
HY-N0546 Ligustroflavone Antagonist 99.90% Unkown
HY-139201B Poly-D-lysine hydrobromide (MW 84000) Agonist / Unkown
HY-W017018S L-Ornithine-d6 hydrochloride Activator 99.2% Unkown
HY-11095 NPS 2390 Inhibitor 99.90% Unkown
HY-122819 Calindol hydrochloride Agonist 99.64% Unkown
HY-W017018S5 L-Ornithine-15N2 hydrochloride Activator 98.90% Unkown
HY-121584 Lycoperodine-1 Agonist 99.82% Unkown
HY-139201D Poly-D-lysine hydrobromide (MW 4000-15000) / Unkown
HY-P4376A Gamma-Glu-Abu TFA Activator 96.83% Unkown
HY-W843885 H-Glu-Thr-OH Activator 98.63% Unkown
HY-103320B (1R,2R)-Calhex 231 hydrochloride Control 98.45% Unkown
HY-W017018S3 L-Ornithine-d2 hydrochloride Activator 99.94% Unkown
HY-117851 AC-265347 Agonist 99.97% Unkown
HY-112171R γ-L-Glutamyl-L-alanine (Standard) Modulator 99.29% Unkown
HY-139201E Poly-D-lysine hydrobromide (MW 150000-300000) Agonist / Unkown
HY-50713 Calcium-Sensing receptor antagonist I Antagonist 98.95% Unkown
HY-107773 GSK3004774 Agonist 99.09% Unkown
HY-15104 Ronacaleret hydrochloride Antagonist 99.81% Unkown
HY-139201H Poly-D-lysine hydrobromide (MW ≥300000) Activator / Unkown
HY-W017018B L-Ornithine monohydrochloride,suitable for cell culture Activator 99.73% Unkown
HY-70037AS Cinacalcet-d3 hydrochloride Agonist 97.63% Unkown
HY-P11668 Gosicalcetide Agonist / Unkown
HY-P4376B Gamma-Glu-Abu acetate Activator / Unkown
HY-15106 SB-423557 Antagonist / Unkown
HY-14401B Encaleret sodium Antagonist / Unkown
HY-103320 Calhex 231 Antagonist / Unkown
HY-139201C Poly-D-lysine hydrobromide (MW 1000-5000) Activator / Unkown
HY-W777503 Calindol hydrochloride-13C,D2 / Unkown
HY-P4376 Gamma-Glu-Abu Activator / Unkown
HY-179475 KP-2067 Agonist / Unkown
HY-10167 Tecalcet Modulator / Unkown
HY-153258 CaSR antagonist-1 Antagonist / Unkown
HY-70037S Cinacalcet-d3 Agonist / Unkown
HY-109106B (Rac)-Upacicalcet 95.0% Unkown
HY-P11832 CaSR agonist peptide-1 Agonist / Unkown
HY-17613S Evocalcet-d4 Activator / Unkown
HY-W017018S1 L-Ornithine-1,2-13C2 hydrochloride Activator / Unkown
HY-15105A SB-423562 hydrochloride Antagonist / Unkown
HY-171446 TAK-075 Antagonist / Unkown
HY-161113 Z8554052021 Activator / Unkown
HY-182543 NPS-467 Activator / Unkown
HY-W653978 Cinacalcet-d4 hydrochloride Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Casr NCBI NCBI:846