Fas - Fas cell surface death receptor Gene

Also Known as Tnfrsf6

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 246097

Summary

Enables protease binding activity and tumor necrosis factor-activated receptor activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to estrogen stimulus; and nervous system development. Located in several cellular components, including apical dendrite; apical plasma membrane; and sarcolemma. Part of CD95 death-inducing signaling complex. Used to study IgA glomerulonephritis; brain glioma; pre-malignant neoplasm; retinal detachment; and transient cerebral ischemia. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; artery disease (multiple); brain ischemia (multiple); eye disease (multiple); and liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic Cancer (multiple); pre-eclampsia (multiple); and urinary system Cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor). [provided by Alliance of Genome Resources, Apr 2022]

Fas Products (1)

mRNA Protein Name
NM_139194.3 NP_631933.2 tumor necrosis factor receptor superfamily member 6 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protease binding IPI
IPI: Inferred from physical interaction
17518537 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10386469 RGD
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
18278556 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
17518537 RGD
enables tumor necrosis factor receptor activity IMP
IMP: Inferred from mutant phenotype
16154149 RGD
Biological Process GO Annotation Evidence References Source
involved in apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
16953119 RGD
involved in cellular response to cobalt ion IEP
IEP: Inferred from expression pattern
15519734 RGD
involved in cellular response to cytokine stimulus IEP
IEP: Inferred from expression pattern
16609999 RGD
involved in cellular response to estrogen stimulus IEP
IEP: Inferred from expression pattern
15038834 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
12111799 RGD
involved in cellular response to hydrostatic pressure IEP
IEP: Inferred from expression pattern
16226958 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
12031707 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
10678925 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
16987298 RGD
involved in cellular response to phenylalanine IEP
IEP: Inferred from expression pattern
23940767 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
10678925 RGD
involved in cellular response to type II interferon IEP
IEP: Inferred from expression pattern
10029626 RGD
involved in chordate embryonic development IEP
IEP: Inferred from expression pattern
11331665 RGD
involved in dendrite regeneration IMP
IMP: Inferred from mutant phenotype
18692025 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
10632538 RGD
involved in maternal process involved in female pregnancy IEP
IEP: Inferred from expression pattern
10084951 RGD
involved in negative regulation of Schwann cell migration IMP
IMP: Inferred from mutant phenotype
29970988 RGD
involved in negative regulation of Schwann cell proliferation IMP
IMP: Inferred from mutant phenotype
29970988 RGD
involved in ovarian follicle atresia IEP
IEP: Inferred from expression pattern
8612534 RGD
involved in ovulation cycle IEP
IEP: Inferred from expression pattern
16461545 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15519734 RGD
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
15519734 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
23940767 RGD
involved in regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16582846 RGD
involved in regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17991709 RGD
involved in regulation of lipid storage IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in response to cycloheximide IEP
IEP: Inferred from expression pattern
9253159 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
17105443 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
16099864 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in response to fluoride IEP
IEP: Inferred from expression pattern
20568470 RGD
involved in response to growth factor IEP
IEP: Inferred from expression pattern
18692025 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
16870148 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
30301943 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
17899301 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
19616844 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
16392621 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
17900647 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16687611 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
17195944 RGD
involved in telencephalon development IEP
IEP: Inferred from expression pattern
10024361 RGD
Cellular Component GO Annotation Evidence References Source
part of CD95 death-inducing signaling complex IDA
IDA: Inferred from direct assay
16493077 RGD
located in apical dendrite IDA
IDA: Inferred from direct assay
10024361 RGD
located in apical plasma membrane IDA
IDA: Inferred from direct assay
12861046 RGD
located in cell surface IDA
IDA: Inferred from direct assay
18045865 RGD
part of death-inducing signaling complex IDA
IDA: Inferred from direct assay
17518537 RGD
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
17195944 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
12522536 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15038834 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17518537 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
10715265 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
11332701 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 6

  • CD95 antigen

  • FASLG receptor

  • Fas (TNF receptor superfamily, member 6)

  • Fas antigen (ATP1)

  • Fas receptor

  • Tumor necrosis factor receptor superfamily, member 6

  • apo-1 antigen

  • apoptosis-mediating surface antigen FAS

Recombinant Fas Proteins

Cat. No. Product Name Accession Purity
HY-P73048 Fas/CD95 Protein, Rat (HEK293, Fc) Q63199 (Q22-K170) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73049 Fas/CD95 Protein, Rat (HEK293, His) Q63199 (Q22-K170) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0515 Ibandronate Sodium Monohydrate Inducer 99.89% Unkown
HY-B0515B Ibandronate Sodium Inducer 99.89% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13721 Phenoxodiol 99.89% Phase 3

Pre-clinical Phase

Bioactive Molecules (60)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150190 F5446 99.73% Unkown
HY-P10102 Kp7-6 99.28% Unkown
HY-103243 TCPOBOP Inhibitor 99.70% Unkown
HY-14414 GSK4112 Inhibitor 99.87% Unkown
HY-12325 GSK2194069 Inhibitor 99.80% Unkown
HY-16100 BI 99179 Inhibitor 99.38% Unkown
HY-N0704 Agrimol B 99.75% Unkown
HY-112716 N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride 99.0% Unkown
HY-133897 (Rac)-Indoximod 99.60% Unkown
HY-P10227 Xelafaslatide Inhibitor 99.88% Unkown
HY-101849 Fasentin 98.0% Unkown
HY-N2116 Ginkgolic acid C17:1 99.80% Unkown
HY-N0686 Pseudoprotodioscin Inhibitor 99.17% Unkown
HY-100755 KR-33493 Inhibitor 99.94% Unkown
HY-21088 3-Amino-2-piperidinone 99.93% Unkown
HY-N4177 Rubrofusarin gentiobioside Inhibitor 99.07% Unkown
HY-Y0598 trans-Chalcone 99.25% Unkown
HY-129624A Bisindolylmaleimide VIII acetate 99.68% Unkown
HY-P6440 Met-12 Inhibitor 99.66% Unkown
HY-122394 Thiolactomycin Inhibitor ≥97.0% Unkown
HY-160912 ELOVL6-IN-5 Inhibitor 95.47% Unkown
HY-N6777 Penicillic acid Inhibitor 99.83% Unkown
HY-103347 M50054 Inhibitor 98.44% Unkown
HY-113963 Ac-​IETD-​CHO Inhibitor 98.59% Unkown
HY-103348 Boc-Asp(OMe)-fluoromethyl ketone Inhibitor 98.0% Unkown
HY-N3011 Iridin 99.72% Unkown
HY-N7930 Crenulatin 99.85% Unkown
HY-N12717 Casuarinin 98.24% Unkown
HY-N0853A Alisol A 24-acetate 98.0% Unkown
HY-108610C (S)-Edelfosine Inducer 99.90% Unkown
HY-N12378 β-Patchoulene 96.88% Unkown
HY-P10815 IP3RCYT Inhibitor 95.87% Unkown
HY-RS04753 FASN Human Pre-designed siRNA Set A / Unkown
HY-RS04754 Fasn Mouse Pre-designed siRNA Set A / Unkown
HY-N7521 Procyanidin C2 / Unkown
HY-111165 SNX-7081 / Unkown
HY-103323 Fas C-Terminal Tripeptide Inhibitor / Unkown
HY-118147 ML356 Inhibitor / Unkown
HY-146197 Apoptotic agent-1 Inducer / Unkown
HY-167879 (Rac)-NPD6433 Inhibitor / Unkown
HY-168877 FMP Activator / Unkown
HY-174133 HSD17B13-IN-104 Inhibitor 95.0% Unkown
HY-175057 Ac-IETD-CHO TFA Inhibitor / Unkown
HY-184685 Antimycobacterial agent-18 Inhibitor / Unkown
HY-N6777S Penicillic acid-13C8 / Unkown
HY-P3779 Amyloid 17-42 Inducer / Unkown
HY-P5797 Fasciculin-II Inhibitor / Unkown
HY-P5798 Fasciculin-I Inhibitor / Unkown
HY-RS04751 FAS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-129624 Bisindolylmaleimide VIII / Unkown
HY-167879A NPD6433 Inhibitor / Unkown
HY-168770 Cl-Necrostatin-1 Inhibitor / Unkown
HY-174713 Human FASLG mRNA / Unkown
HY-174714 Human FAS mRNA / Unkown
HY-187335 HadAB/InhA=IN-1 Inhibitor / Unkown
HY-N10612 Petasin / Unkown
HY-N5134A ara-GMP / Unkown
HY-P10401 TAT-GluR6-9c Antagonist / Unkown
HY-RS16712 Fas Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23147 Fas Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99133 Anti-Mouse Fas Ligand Antibody (MFL3) Inhibitor / Unkown
HY-P991606 TRX585 / Unkown
HY-P992072 Anti-Human/Mouse CD95 Antibody (HFE7A) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fas NCBI NCBI:355