ICAM1 - Icam1 intercellular adhesion molecule 1 Gene

Also Known as CD54; ICAM

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25464

Summary

Enables Integrin binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and gonad development. Located in cell surface; extracellular space; and plasma membrane. Used to study diabetic angiopathy; mesenteric vascular occlusion; nephritis; pre-eclampsia; and uveitis. Biomarker of several diseases, including cerebrovascular disease (multiple); colitis (multiple); kidney failure (multiple); lung disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; diabetic retinopathy; inflammatory bowel disease (multiple); and liver cirrhosis. Orthologous to human ICAM1 (intercellular adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

ICAM1 Products (1)

mRNA Protein Name
NM_012967.1 NP_037099.1 intercellular adhesion molecule 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables integrin binding IMP
IMP: Inferred from mutant phenotype
16825578 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
10556544 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in acute inflammatory response to antigenic stimulus IMP
IMP: Inferred from mutant phenotype
7641842 RGD
involved in cell-cell adhesion IDA
IDA: Inferred from direct assay
12097510 RGD
involved in cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
8938183 RGD
involved in cellular response to alkaloid IEP
IEP: Inferred from expression pattern
20674665 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
10976991 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
20627932 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
20631551 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
20643106 RGD
involved in cellular response to interleukin-6 IEP
IEP: Inferred from expression pattern
7865494 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
20674665 RGD
involved in cellular response to nutrient levels IEP
IEP: Inferred from expression pattern
20643106 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
15087287 RGD
involved in cellular response to type II interferon IEP
IEP: Inferred from expression pattern
7865494 RGD
involved in cellular senescence IEP
IEP: Inferred from expression pattern
20421514 RGD
involved in establishment of Sertoli cell barrier IDA
IDA: Inferred from direct assay
22976294 RGD
involved in establishment of endothelial intestinal barrier IMP
IMP: Inferred from mutant phenotype
10201790 RGD
involved in negative regulation of calcium ion transport IDA
IDA: Inferred from direct assay
15087287 RGD
involved in ovarian follicle development IEP
IEP: Inferred from expression pattern
20591976 RGD
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
17662049 RGD
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
9062344 RGD
involved in positive regulation of actin filament polymerization IDA
IDA: Inferred from direct assay
17662049 RGD
involved in positive regulation of leukocyte adhesion to vascular endothelial cell IMP
IMP: Inferred from mutant phenotype
10517906 RGD
involved in positive regulation of nitric oxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
9062344 RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
17662049 RGD
involved in positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
12296653 RGD
involved in regulation of cell shape IMP
IMP: Inferred from mutant phenotype
15087287 RGD
involved in response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine IEP
IEP: Inferred from expression pattern
20870297 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
20599905 RGD
involved in response to amphetamine IEP
IEP: Inferred from expression pattern
21093552 RGD
involved in response to copper ion IEP
IEP: Inferred from expression pattern
20544302 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
20726338 RGD
involved in response to gonadotropin IEP
IEP: Inferred from expression pattern
20591976 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
19823174 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
18791499 RGD
involved in response to ionizing radiation IEP
IEP: Inferred from expression pattern
20385203 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
20871155 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
20740350 RGD
involved in response to sulfur dioxide IEP
IEP: Inferred from expression pattern
20951496 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
20871620 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in cell surface IDA
IDA: Inferred from direct assay
8938183 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
18413153 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

intercellular adhesion molecule 1

  • ICAM-1

Recombinant ICAM1 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P73114 ICAM-1/CD54 Protein, Rat (HEK293, His) Q00238 (Q28-T493) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73909 ICAM-1/CD54 Protein, Rat (HEK293, Fc) Q00238 (Q28-T493) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-19344 Lifitegrast Antagonist 99.29% Unkown
HY-19344A Lifitegrast sodium Inhibitor 99.20% Unkown
HY-B0665 Fibrin / Unkown
Inhibitory Antibodies (1)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-108831 Natalizumab Inhibitor 99.10% Unkown

Clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-145728 Alicaforsen Inhibitor / Phase 3
HY-167874 ASP-8731 Inhibitor 98.42% Phase 1
Inhibitory Antibodies (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P99473 Bersanlimab Inhibitor 99.85% Phase 2

Pre-clinical Phase

Bioactive Molecules (47)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-N0637 Eriodictyol Inhibitor 99.55% Unkown
HY-33037 Phenazine-1-carboxylic acid Inhibitor 99.97% Unkown
HY-100226 A-205804 Inhibitor 98.96% Unkown
HY-15701 Leukadherin-1 Agonist 98.0% Unkown
HY-112868B ABH hydrochloride 99.90% Unkown
HY-P1110 AF12198 Inhibitor 99.92% Unkown
HY-110117 BIRT 377 Inhibitor 99.82% Unkown
HY-N2464 Maltotetraose Inhibitor 99.88% Unkown
HY-U00003 ICAM-1-IN-1 Inhibitor 99.73% Unkown
HY-N0602 Ginsenoside Rg2 Inhibitor 98.71% Unkown
HY-N2110 Phellopterin 99.94% Unkown
HY-107587 A-286982 Inhibitor 98.12% Unkown
HY-N1353 Rhamnocitrin Inhibitor 99.67% Unkown
HY-125740 Malvidin-3-glucoside chloride Inhibitor 99.87% Unkown
HY-B2162D Chondroitin sulfate (from chicken) Inhibitor 99.61% Unkown
HY-N0637A (±)-Eriodictyol Inhibitor 99.9% Unkown
HY-W588250 Surfactin C1 Antagonist 99.31% Unkown
HY-145728B (R/S)-Alicaforsen Inhibitor 99.27% Unkown
HY-P2508 MUC1, mucin core 98.84% Unkown
HY-10596 BMS-688521 Inhibitor 98.62% Unkown
HY-N12717 Casuarinin 98.24% Unkown
HY-101961 Tyrphostin AG 1288 Inhibitor 98.68% Unkown
HY-110086 RWJ 50271 Inhibitor 99.23% Unkown
HY-W013557 3-Hydroxyxanthone Inhibitor 98.38% Unkown
HY-P5767 Fibrinogen γ-chain (117-133) Inhibitor 99.88% Unkown
HY-W241255 2-Aminoindan-2-carboxylic acid / Unkown
HY-13412 Cariporide (mesilate) Modulator / Unkown
HY-145728A Alicaforsen sodium Inhibitor / Unkown
HY-122192 ICAM-1988 Antagonist / Unkown
HY-143243 Antioxidant agent-5 Inhibitor / Unkown
HY-180939 LFA-1-IN-2 Inhibitor / Unkown
HY-186198 FTS-MOM Inhibitor / Unkown
HY-N0602R Ginsenoside Rg2 (Standard) Inhibitor / Unkown
HY-N11996 Aloenin aglycone / Unkown
HY-N14915 Adxanthromycin A Inhibitor / Unkown
HY-N15519 Crocatin B Inhibitor / Unkown
HY-N4275 Oleaside A / Unkown
HY-P11799 cLABL Ligand / Unkown
HY-RS06512 ICAM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-112868A ABH Inhibitor / Unkown
HY-183448 ETMTC / Unkown
HY-183516 Osteoprotegerin / Unkown
HY-19344S Lifitegrast-d4 / Unkown
HY-19344S1 Lifitegrast-d6 / Unkown
HY-19344S2 Lifitegrast-d4-1 Antagonist / Unkown
HY-RS16658 Icam1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23093 Icam1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (10)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-108831A Natalizumab (Anti-CD49d) Inhibitor 99.71% Unkown
HY-P99127 Anti-Mouse CD54 Antibody (YN1/1.7.4) Inhibitor 95.00% Unkown
HY-P99336 Enlimomab Inhibitor 95.00% Unkown
HY-P990857 Anti-CD54/ICAM-1 Antibody (R6-5-D6) Inhibitor / Unkown
HY-P991250 MSH-TP15e Inhibitor / Unkown
HY-P991591 MOR101 Inhibitor / Unkown
HY-P991819 Anti-Mouse ICAM-1 Antibody (BE29G1) Inhibitor / Unkown
HY-P992053 Anti-CD11a Antibody (MHM24) Inhibitor / Unkown
HY-P992200 Anti-CD146 Antibody (AA98) / Unkown
HY-P992413 MOR102 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ICAM1 NCBI NCBI:3383