Irak4 - interleukin-1 receptor-associated kinase 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 300177

About Irak4

Primary_assembly 7: 125,682,488-125,717,837 forward strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 202 orthologues, 4 paralogues and is associated with 8 phenotypes. Biased expression in Spleen (RPKM 52.5), Thymus (RPKM 38.7) and 9 other tissues.

Summary

Predicted to enable interleukin-1 receptor binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Involved in JNK cascade; cytokine-mediated signaling pathway; and positive regulation of smooth muscle cell proliferation. Located in extracellular space. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human IRAK4 (interleukin 1 receptor associated kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Irak4 Products (1)

mRNA Protein Name
NM_001106791.2 NP_001100261.2 interleukin-1 receptor-associated kinase 4

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in JNK cascade IMP
IMP: Inferred from mutant phenotype
15890643 RGD
involved in cytokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
15890643 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
15890643 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
23073793 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Irak4 Protein Structure

Death_IRAK4

Death_IRAK4: cd08793 (8 - 107)

STKc_IRAK4

STKc_IRAK4: cd14158 (171 - 457)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 461 a.a.
Protein Preferred Names Protein Names

interleukin-1 receptor-associated kinase 4

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-19836 Zimlovisertib Inhibitor 99.94% Phase 2
HY-135317 Emavusertib Inhibitor 99.97% Phase 2
HY-139374 Zabedosertib Inhibitor 98.22% Phase 2
HY-160487 KME-2780 Inhibitor 98.94% Phase 2
HY-109585 IRAK4-IN-7 Inhibitor 99.36% Phase 2
HY-153368 Zomiradomide Degrader 98.04% Phase 1

Pre-clinical Phase

Bioactive Molecules (84)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145483 KT-474 Inhibitor 99.77% Unkown
HY-18992 AS2444697 Inhibitor 99.54% Unkown
HY-147141 HS-276 Inhibitor 98.93% Unkown
HY-153188 JNJ-1013 Degrader 99.97% Unkown
HY-111101 AZ1495 Inhibitor 98.07% Unkown
HY-114181 IRAK4-IN-4 Inhibitor 99.55% Unkown
HY-129966 PROTAC IRAK4 degrader-1 Degrader 99.77% Unkown
HY-148290 KTX-951 Degrader 99.60% Unkown
HY-162359 BIO-7488 Inhibitor 99.44% Unkown
HY-159953 IRAK1/4/pan-FLT3 Kinase-IN-1 Inhibitor 99.25% Unkown
HY-134911 HS-243 Inhibitor 99.95% Unkown
HY-135382A PROTAC IRAK4 degrader-3 Degrader 98.24% Unkown
HY-150735 IRAK4-IN-20 Inhibitor 97.04% Unkown
HY-175764 FIP22 Degrader 98.53% Unkown
HY-175022 PROTAC IRAK4 degrader-13 Degrader 99.58% Unkown
HY-153673 PROTAC IRAK4 degrader-8 Degrader 99.70% Unkown
HY-179094 PSP-0119 Degrader 98.65% Unkown
HY-146112 IRAK4-IN-14 Inhibitor 99.01% Unkown
HY-153224 GLPG2534 Inhibitor 98.73% Unkown
HY-77048 IRAK-4 protein kinase inhibitor 2 Inhibitor 98.07% Unkown
HY-174455A APH02174 hemiformic Degrader / Unkown
HY-123854 PF-06426779 Inhibitor 99.89% Unkown
HY-13276 IRAK inhibitor 2 Inhibitor 99.19% Unkown
HY-174455 APH02174 Degrader / Unkown
HY-131903 HS271 Inhibitor 99.92% Unkown
HY-177515 IRAK4 modulator-2 Inhibitor 99.86% Unkown
HY-159953A IRAK1/4/pan-FLT3 Kinase-IN-1 hydrochloride Inhibitor 98.46% Unkown
HY-129967 PROTAC IRAK4 ligand-1 Ligand 99.49% Unkown
HY-148238 GNE-2256 Inhibitor 99.14% Unkown
HY-13278 IRAK inhibitor 4 Inhibitor 99.77% Unkown
HY-179095 UR241-2 Inhibitor 99.68% Unkown
HY-13278A IRAK inhibitor 4 (trans) Inhibitor 99.02% Unkown
HY-135317B Emavusertib hydrochloride Inhibitor / Unkown
HY-143231 IRAK4-IN-8 Inhibitor / Unkown
HY-139317 PROTAC IRAK4 degrader-6 Degrader / Unkown
HY-48932 IRAK4 ligand-12 Ligand / Unkown
HY-146111 IRAK4-IN-13 Inhibitor / Unkown
HY-148275 KTX-955 Inhibitor / Unkown
HY-178012 GLPG4471 Inhibitor / Unkown
HY-148277 KTX-612 / Unkown
HY-147141B HS-276 formic Inhibitor / Unkown
HY-148276 KTX-497 / Unkown
HY-150732 IRAK4-IN-18 Inhibitor / Unkown
HY-139318 IRAK4 ligand-16 Ligand / Unkown
HY-161620 DW18134 Inhibitor / Unkown
HY-150733 IRAK4-IN-19 Inhibitor / Unkown
HY-147141A HS-276 hydrochloride Inhibitor / Unkown
HY-168611 IRAK4 ligand-18 Degrader / Unkown
HY-139315 PROTAC IRAK4 degrader-4 Degrader / Unkown
HY-146072 IRAK4-IN-11 Inhibitor / Unkown
HY-146073 IRAK4-IN-12 Inhibitor / Unkown
HY-183799 GSI526 Degrader / Unkown
HY-183800 JH-l-25-NH2 Ligand / Unkown
HY-146113 IRAK4-IN-15 Inhibitor / Unkown
HY-181708 PROTAC IRAK4 degrader-14 Degrader / Unkown
HY-172591 IRAK4 ligand-13 Ligand / Unkown
HY-139316 PROTAC IRAK4 degrader-5 Inhibitor / Unkown
HY-150594 IRAK4-IN-17 Inhibitor / Unkown
HY-162641 AF-45 Inhibitor / Unkown
HY-162538 LC-MI-3 Degrader / Unkown
HY-143486 IRAK4-IN-10 Inhibitor / Unkown
HY-172372 IRAK4-IN-30 Inhibitor / Unkown
HY-135382 PROTAC IRAK4 degrader-2 Inhibitor / Unkown
HY-158760 PROTAC IRAK4 degrader-11 Degrader / Unkown
HY-143485 IRAK4-IN-9 Inhibitor / Unkown
HY-124995 BMS-986126 Inhibitor / Unkown
HY-W900240 BMS-978299 Inhibitor / Unkown
HY-184915 APH003 Degrader / Unkown
HY-123956 HG-12-6 Inhibitor / Unkown
HY-168586 PROTAC IRAK4 degrader-12 Degrader / Unkown
HY-145484 PROTAC IRAK4 ligand-3 / Unkown
HY-168311 PROTAC IRAK4 ligand-5 / Unkown
HY-184916 IRAK4 ligand-17 Degrader / Unkown
HY-155574 IRAK4-IN-27 Inhibitor / Unkown
HY-150593 IRAK4-IN-16 Inhibitor / Unkown
HY-142662 PROTAC IRAK3 degrader-1 Degrader / Unkown
HY-160654 IRAK4 modulator-1 Modulator 99.11% Unkown
HY-149345 IRAK4-IN-24 Inhibitor / Unkown
HY-158374 BIO-8169 Inhibitor / Unkown
HY-168982 Lomonitinib Inhibitor / Unkown
HY-174470 IRAK4 ligand-14 Ligand / Unkown
HY-176197 IRAK4-IN-31 Inhibitor / Unkown
HY-174843 IRAK4-IN-32 Inhibitor / Unkown
HY-180908 IRAK4-IN-34 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irak4 NCBI NCBI:51135