2. Gene
  3. Ripk1 - receptor interacting serine/threonine kinase 1 Gene

Ripk1 - receptor interacting serine/threonine kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 306886 | Gene type: protein coding

About Ripk1

Primary_assembly 17: 30,839,650-30,871,824 reverse strand.mRatBN7.2:CM026990.1

This gene has 1 transcript (splice variant), 198 orthologues, 23 paralogues and is associated with 5 phenotypes. Biased expression in Spleen (RPKM 117.7), Lung (RPKM 117.5) and 9 other tissues.

Summary

Enables death receptor binding activity. Involved in positive regulation of necroptotic process. Located in membrane raft. Part of protein-containing complex. Human ortholog(s) of this gene implicated in immunodeficiency 57. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ripk1 Products(1)

mRNA Protein Name
NM_001107350.1 NP_001100820.1 receptor-interacting serine/threonine-protein kinase 1

Ripk1 Protein Structure

PKc_like

PKc_like: cl21453 (22 - 289)

Death_RIP1

Death_RIP1: cd08777 (569 - 654)

  • 0
  • 200
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  • 600
  • 658 a.a.
Protein Preferred Names Protein Names

receptor-interacting serine/threonine-protein kinase 1

RIP

receptor (TNFRSF)-interacting serine-threonine kinase 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (19)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14622A Necrostatin 2 racemate Inhibitor 99.65% Unkown
HY-134050 Apostatin-1 Inhibitor 99.24% Unkown
HY-138779 ICCB-19 hydrochloride Inhibitor 99.24% Unkown
HY-128348 PK68 Inhibitor 99.92% Unkown
HY-132203 Necrostatin-34 Inhibitor 98.75% Unkown
HY-18901 RIPK1-IN-4 Inhibitor 98.39% Unkown
HY-124546 Necrostatin-5 Inhibitor 98.43% Unkown
HY-148365 NecroIr1 Activator 98.02% Unkown
HY-148366 NecroIr2 Activator 98.99% Unkown
HY-149258 KWCN-41 Inhibitor 99.83% Unkown
HY-151873 SZM679 Inhibitor 99.59% Unkown
HY-160216 RIPK1-IN-18 Inhibitor / Unkown
HY-153434 RIP1 kinase inhibitor 4 Inhibitor / Unkown
HY-162237 RIPK1-IN-22 Inhibitor / Unkown
HY-153437 RIP1 kinase inhibitor 7 Inhibitor / Unkown
HY-157963 RIPK1-IN-23 Inhibitor / Unkown
HY-157456 RIPK1-IN-19 Inhibitor / Unkown
HY-149052 SZM-1209 Inhibitor / Unkown
HY-146758 RIPK1-IN-14 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ripk1 NCBI NCBI:8737