Ripk1 - receptor interacting serine/threonine kinase 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 306886

About Ripk1

Primary_assembly 17: 30,839,650-30,871,824 reverse strand.mRatBN7.2:CM026990.1

This gene has 1 transcript (splice variant), 198 orthologues, 23 paralogues and is associated with 5 phenotypes. Biased expression in Spleen (RPKM 117.7), Lung (RPKM 117.5) and 9 other tissues.

Summary

Enables death receptor binding activity. Involved in positive regulation of necroptotic process. Located in membrane raft. Part of protein-containing complex. Human ortholog(s) of this gene implicated in immunodeficiency 57. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ripk1 Products (1)

mRNA Protein Name
NM_001107350.1 NP_001100820.1 receptor-interacting serine/threonine-protein kinase 1

Ripk1 Protein Structure

PKc_like

PKc_like: cl21453 (22 - 289)

Death_RIP1

Death_RIP1: cd08777 (569 - 654)

  • 0
  • 200
  • 400
  • 600
  • 658 a.a.
Protein Preferred Names Protein Names

receptor-interacting serine/threonine-protein kinase 1

  • RIP

  • receptor (TNFRSF)-interacting serine-threonine kinase 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-114371 Eclitasertib Inhibitor 99.80% Phase 2
HY-148787 Oditrasertib Inhibitor 99.84% Phase 2
HY-148297 Ocadusertib Inhibitor 99.57% Phase 2
HY-152846 Flizasertib Inhibitor 99.9% Phase 2

Pre-clinical Phase

Bioactive Molecules (59)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-14622A Necrostatin 2 racemate Inhibitor 99.57% Unkown
HY-134050 Apostatin-1 Inhibitor 99.64% Unkown
HY-138779 ICCB-19 hydrochloride Inhibitor 99.25% Unkown
HY-14622 Necrostatin 2 Inhibitor 99.78% Unkown
HY-N0546 Ligustroflavone Inhibitor 99.90% Unkown
HY-124546 Necrostatin-5 Inhibitor 99.40% Unkown
HY-153598 LD4172 Degrader 98.32% Unkown
HY-128348 PK68 Inhibitor 99.92% Unkown
HY-18901 RIPK1-IN-4 Inhibitor 98.89% Unkown
HY-161059 ZB-R-55 Inhibitor 99.39% Unkown
HY-161060 Zharp1-211 Inhibitor 99.15% Unkown
HY-157039 RIPK1-IN-17 Inhibitor 97.09% Unkown
HY-14622B Necrostatin 2 (S enantiomer) Inhibitor 99.76% Unkown
HY-157456 RIPK1-IN-19 Inhibitor 98.87% Unkown
HY-120548 KBU2046 98.85% Unkown
HY-151873 SZM679 Inhibitor 99.59% Unkown
HY-149258 KWCN-41 Inhibitor 99.83% Unkown
HY-148366 NecroIr2 Activator 98.02% Unkown
HY-148365 NecroIr1 Activator 98.53% Unkown
HY-132203 Necrostatin-34 Inhibitor 98.90% Unkown
HY-175370 PROTAC RIPK1 Degrader-1 Degrader 99.66% Unkown
HY-173574 RIPK1-IN-31 Modulator / Unkown
HY-178762S RIPK1-IN-35 Inhibitor / Unkown
HY-173185 RIP1-IN-1 Inhibitor / Unkown
HY-161911 Necroptosis-IN-5 Inhibitor / Unkown
HY-153437 PB830 Inhibitor / Unkown
HY-181596 WJH-C19 Inhibitor 98.65% Unkown
HY-187502 Jak1 RIMTAC-1 Ligand / Unkown
HY-179680 RIPK1-IN-38 Inhibitor / Unkown
HY-180806 RIPK1-IN-39 Inhibitor / Unkown
HY-162237 RIPK1-IN-22 Inhibitor / Unkown
HY-181062 VWK147 Inhibitor / Unkown
HY-187500 Akt RIMTAC-1 Ligand / Unkown
HY-149052 SZM-1209 Inhibitor / Unkown
HY-160216 RIPK1-IN-18 Inhibitor / Unkown
HY-184686 RIPK1-IN-42 Inhibitor / Unkown
HY-179235 RIPK1-IN-37 Inhibitor / Unkown
HY-181944 RIPK1-IN-40 Inhibitor / Unkown
HY-146758 RIPK1-IN-14 Inhibitor / Unkown
HY-153434 RIP1 kinase inhibitor 4 Inhibitor / Unkown
HY-178163 Zharp1-163 Inhibitor / Unkown
HY-183781 RIPK1-IN-41 Inhibitor / Unkown
HY-157963 RIPK1-IN-23 Inhibitor / Unkown
HY-158334 NDs-IN-1 Inhibitor / Unkown
HY-169107 RIPK1-IN-25 Inhibitor / Unkown
HY-175007 RIPK1-IN-32 Inhibitor / Unkown
HY-170232 RIPK1-IN-29 Inhibitor / Unkown
HY-143726 RIPK1-IN-8 Inhibitor / Unkown
HY-184001 LT-1339-553 Inhibitor / Unkown
HY-179323 RIPK1-IN-36 Inhibitor / Unkown
HY-144276 RIPK1-IN-11 Inhibitor / Unkown
HY-187391 RIPK1-ligand-4 / Unkown
HY-183564 RIPK1/RIPK3-PPI-IN-1 Inhibitor / Unkown
HY-W319332 Necrostatin-21 Inhibitor / Unkown
HY-P10977 Tat-ASIC1a (1-20) (mouse, rat) Inhibitor / Unkown
HY-178464 RIPK1-IN-34 Inhibitor / Unkown
HY-175371 RIPK1-ligand-2 Inhibitor / Unkown
HY-18899 Nec-3a Inhibitor / Unkown
HY-175374 RIPK1 ligand-Linker Conjugate-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ripk1 NCBI NCBI:8737