MAP1LC3B - microtubule associated protein 1 light chain 3 beta Gene

Also Known as LC3B; ATG8F; MAP1LC3B-a; MAP1A/1BLC3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81631

About MAP1LC3B

Cytogenetic location: 16q24.2 Genomic coordinates (GRCh38): 16:87,392,336-87,404,774 (from NCBI)

This gene has 6 transcripts (splice variants), 173 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 94.3), brain (RPKM 58.8) and 25 other tissues.

Summary

The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in Autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008]

MAP1LC3B Products (1)

mRNA Protein Name
NM_022818.5 NP_073729.1 microtubule-associated proteins 1A/1B light chain 3B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ceramide binding IDA
IDA: Inferred from direct assay
22922758 GOA
enables phosphatidylethanolamine binding IDA
IDA: Inferred from direct assay
15355958 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15187094 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
25127057 GOA
Biological Process GO Annotation Evidence References Source
involved in autophagosome assembly IDA
IDA: Inferred from direct assay
37943659 GOA
involved in autophagosome maturation IDA
IDA: Inferred from direct assay
28223137 GOA
involved in autophagy IDA
IDA: Inferred from direct assay
23629966 GOA
involved in cellular response to starvation IDA
IDA: Inferred from direct assay
28223137 GOA
involved in macroautophagy IDA
IDA: Inferred from direct assay
28223137 GOA
involved in mitophagy IDA
IDA: Inferred from direct assay
28017329 GOA
involved in mitophagy IGI
IGI: Inferred from genetic interaction
19279012 GOA
Cellular Component GO Annotation Evidence References Source
located in autophagosome IDA
IDA: Inferred from direct assay
22948227 GOA
located in autophagosome membrane IDA
IDA: Inferred from direct assay
33499712 GOA
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
30420355 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
25215947 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP1LC3B Protein Structure

Atg8

Atg8: Autophagy protein Atg8 ubiquitin like (15 - 120)

  • 0
  • 100
  • 125 a.a.
Protein Preferred Names Protein Names

microtubule-associated proteins 1A/1B light chain 3B

  • MAP1 light chain 3-like protein 2

MAP1LC3B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MAP1LC3B Q9GZQ8 ATG5 Homo sapiens Q9H1Y0
Anti Tag CoIP
20562859
Intra
MAP1LC3B Q9GZQ8 IRGQ Homo sapiens Q8WZA9
BioID
34524948
Intra
MAP1LC3B Q9GZQ8 HSPA1A Homo sapiens P0DMV8
Validated Y2H
32814053
Intra
MAP1LC3B Q9GZQ8 HSPA1A Homo sapiens P0DMV8
Y2H Array
32814053
Intra
MAP1LC3B Q9GZQ8 HSPA1A Homo sapiens P0DMV8
Y2H Pooling
32814053
Intra
MAP1LC3B Q9GZQ8 CLINT1 Homo sapiens Q14677
Anti Tag CoIP
20562859
Intra
MAP1LC3B Q9GZQ8 WDFY3 Homo sapiens Q8IZQ1
Anti Tag CoIP
18083104
Intra
MAP1LC3B Q9GZQ8 WDFY3 Homo sapiens Q8IZQ1
IF
24668264
Intra
MAP1LC3B Q9GZQ8 WDFY3 Homo sapiens Q8IZQ1
Pull Down
24668264
Cross
MAP1LC3B Q9GZQ8 Bnip3l Mus musculus Q9Z2F7
NMR
20010802
Cross
MAP1LC3B Q9GZQ8 Bnip3l Mus musculus Q9Z2F7
ITC
20010802
Intra
MAP1LC3B Q9GZQ8 KBTBD6 Homo sapiens Q86V97
Pull Down
25684205
Cross
MAP1LC3B Q9GZQ8 ATG7 Saccharomyces cerevisiae P38862
GMS
22056771
Intra
MAP1LC3B Q9GZQ8 ATG13 Homo sapiens O75143
Pull Down
24290141
Intra
MAP1LC3B Q9GZQ8 FYCO1 Homo sapiens Q9BQS8
Anti Tag CoIP
20562859
Intra
MAP1LC3B Q9GZQ8 FYCO1 Homo sapiens Q9BQS8
TAP
24089205
Intra
MAP1LC3B Q9GZQ8 FYCO1 Homo sapiens Q9BQS8
Anti Tag CoIP
35271311
Intra
MAP1LC3B Q9GZQ8 STBD1 Homo sapiens O95210
Pull Down
20562859
Intra
MAP1LC3B Q9GZQ8 TBC1D2B Homo sapiens Q9UPU7
Anti Tag CoIP
20562859
Intra
MAP1LC3B Q9GZQ8 TBC1D2B Homo sapiens Q9UPU7
Pull Down
20562859
Intra
MAP1LC3B Q9GZQ8 FUNDC1 Homo sapiens Q8IVP5
IF
24671035
Intra
MAP1LC3B Q9GZQ8 FUNDC1 Homo sapiens Q8IVP5
Anti Tag CoIP
20562859
Intra
MAP1LC3B Q9GZQ8 FUNDC1 Homo sapiens Q8IVP5
Y2H Prey Pooling
25416956
Intra
MAP1LC3B Q9GZQ8 FUNDC1 Homo sapiens Q8IVP5
Anti Bait CoIP
24671035
Intra
MAP1LC3B Q9GZQ8 SQSTM1 Homo sapiens Q13501
Anti Tag CoIP
18083104
Intra
MAP1LC3B Q9GZQ8 SQSTM1 Homo sapiens Q13501
Y2H Pooling
16169070
Intra
MAP1LC3B Q9GZQ8 SQSTM1 Homo sapiens Q13501
FPS
37219487
Intra
MAP1LC3B Q9GZQ8 SQSTM1 Homo sapiens Q13501
Y2H
20010802
Intra
MAP1LC3B Q9GZQ8 SQSTM1 Homo sapiens Q13501
Y2H Array
32296183
Intra
MAP1LC3B Q9GZQ8 SQSTM1 Homo sapiens Q13501
Pull Down
24668264
Intra
MAP1LC3B Q9GZQ8 SQSTM1 Homo sapiens Q13501
Pull Down
18083104
Intra
MAP1LC3B Q9GZQ8 SQSTM1 Homo sapiens Q13501
Anti Bait CoIP
26524528
Intra
MAP1LC3B Q9GZQ8 SQSTM1 Homo sapiens Q13501
FPS
39009827
Intra
MAP1LC3B Q9GZQ8 SQSTM1 Homo sapiens Q13501
Y2H
21900206
Intra
MAP1LC3B Q9GZQ8 SQSTM1 Homo sapiens Q13501
Y2H Prey Pooling
32296183
Intra
MAP1LC3B Q9GZQ8 SQSTM1 Homo sapiens Q13501
Phage Display
37219487
Intra
MAP1LC3B Q9GZQ8 SQSTM1 Homo sapiens Q13501
ITC
20010802
Intra
MAP1LC3B Q9GZQ8 SQSTM1 Homo sapiens Q13501
Pull Down
19250911
Intra
MAP1LC3B Q9GZQ8 SQSTM1 Homo sapiens Q13501
TAP
24089205
Intra
MAP1LC3B Q9GZQ8 SQSTM1 Homo sapiens Q13501
Anti Tag CoIP
20562859
Intra
MAP1LC3B Q9GZQ8 SQSTM1 Homo sapiens Q13501
Phage Display
39009827
Intra
MAP1LC3B Q9GZQ8 NIPSNAP2 Homo sapiens O75323
Anti Tag CoIP
20562859
Intra
MAP1LC3B Q9GZQ8 WIPF1 Homo sapiens O43516
IF
36935496
Intra
MAP1LC3B Q9GZQ8 WIPF1 Homo sapiens O43516
Anti Bait CoIP
36935496
Intra
MAP1LC3B Q9GZQ8 SAFB Homo sapiens Q15424
Y2H
21900206
Intra
MAP1LC3B Q9GZQ8 SAFB Homo sapiens Q15424
Anti Tag CoIP
20562859
Intra
MAP1LC3B Q9GZQ8 LUC7L2 Homo sapiens Q9Y383
Y2H Pooling
16169070
Intra
MAP1LC3B Q9GZQ8 LUC7L2 Homo sapiens Q9Y383
Anti Tag CoIP
20562859
Intra
MAP1LC3B Q9GZQ8 SAFB2 Homo sapiens Q14151
Pull Down
20562859
Intra
MAP1LC3B Q9GZQ8 SAFB2 Homo sapiens Q14151
Anti Tag CoIP
20562859
Intra
MAP1LC3B Q9GZQ8 TBK1 Homo sapiens Q9UHD2
FPS
37219487
Intra
MAP1LC3B Q9GZQ8 TBK1 Homo sapiens Q9UHD2
ITC
37219487
Intra
MAP1LC3B Q9GZQ8 HADHA Homo sapiens P40939
Anti Tag CoIP
20562859
Intra
MAP1LC3B Q9GZQ8 TNIP1 Homo sapiens Q15025
Y2H Array
31515488
Intra
MAP1LC3B Q9GZQ8 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
25416956
Intra
MAP1LC3B Q9GZQ8 TNIP1 Homo sapiens Q15025
Validated Y2H
25416956
Intra
MAP1LC3B Q9GZQ8 STK4 Homo sapiens Q13043
Anti Tag CoIP
35271311
Intra
MAP1LC3B Q9GZQ8 STK4 Homo sapiens Q13043
Anti Tag CoIP
20562859
Intra
MAP1LC3B Q9GZQ8 RASSF5 Homo sapiens Q8WWW0
Anti Tag CoIP
20562859
Intra
MAP1LC3B Q9GZQ8 KBTBD7 Homo sapiens Q8WVZ9
Pull Down
25684205
Intra
MAP1LC3B Q9GZQ8 KBTBD7 Homo sapiens Q8WVZ9
Pull Down
20562859
Intra
MAP1LC3B Q9GZQ8 KBTBD7 Homo sapiens Q8WVZ9
Y2H Pooling
16169070
Intra
MAP1LC3B Q9GZQ8 CTNNB1 Homo sapiens P35222
Pull Down
23736261
Intra
MAP1LC3B Q9GZQ8 ATG16L1 Homo sapiens Q676U5
Anti Tag CoIP
20562859
Intra
MAP1LC3B Q9GZQ8 CAV1 Homo sapiens Q03135
Anti Bait CoIP
20956295
Intra
MAP1LC3B Q9GZQ8 MESD Homo sapiens Q14696
Y2H Prey Pooling
32296183
Intra
MAP1LC3B Q9GZQ8 MESD Homo sapiens Q14696
Y2H Array
32296183
Cross
MAP1LC3B Q9GZQ8 Sqstm1 Mus musculus Q64337
Pull Down
18083104
Cross
MAP1LC3B Q9GZQ8 Sqstm1 Mus musculus Q64337
IF
18083104
Cross
MAP1LC3B Q9GZQ8 Sqstm1 Mus musculus Q64337
EM
18083104
Cross
MAP1LC3B Q9GZQ8 Sqstm1 Mus musculus Q64337
Anti Tag CoIP
18083104
Intra
MAP1LC3B Q9GZQ8 TTN Homo sapiens Q8WZ42
Phage Display
35044719
Intra
MAP1LC3B Q9GZQ8 TTN Homo sapiens Q8WZ42
Anti Tag CoIP
20562859
Intra
MAP1LC3B Q9GZQ8 ATG4B Homo sapiens Q9Y4P1
Anti Tag CoIP
20562859
Intra
MAP1LC3B Q9GZQ8 ATG4B Homo sapiens Q9Y4P1
Y2H Pooling
16169070
Intra
MAP1LC3B Q9GZQ8 ATG4B Homo sapiens Q9Y4P1
Validated Y2H
32296183
Intra
MAP1LC3B Q9GZQ8 ATG4B Homo sapiens Q9Y4P1
Y2H Array
32296183
Intra
MAP1LC3B Q9GZQ8 ATG4B Homo sapiens Q9Y4P1
Y2H
20010802
Intra
MAP1LC3B Q9GZQ8 ATG4B Homo sapiens Q9Y4P1
Y2H
21900206
Intra
MAP1LC3B Q9GZQ8 ATG4B Homo sapiens Q9Y4P1
Y2H Prey Pooling
32296183
Intra
MAP1LC3B Q9GZQ8 ATG4B Homo sapiens Q9Y4P1
Anti Tag CoIP
18083104
Intra
MAP1LC3B Q9GZQ8 RETREG2 Homo sapiens Q8NC44
Y2H
21900206
Intra
MAP1LC3B Q9GZQ8 OFD1 Homo sapiens O75665
IF
33368531
Intra
MAP1LC3B Q9GZQ8 OFD1 Homo sapiens O75665
TAP
24089205
Intra
MAP1LC3B Q9GZQ8 OFD1 Homo sapiens O75665
Anti Bait CoIP
24089205
Intra
MAP1LC3B Q9GZQ8 OFD1 Homo sapiens O75665
Pull Down
33368531
Intra
MAP1LC3B Q9GZQ8 NEDD4 Homo sapiens P46934
Phage Display
35044719
Intra
MAP1LC3B Q9GZQ8 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
25416956
Intra
MAP1LC3B Q9GZQ8 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra
MAP1LC3B Q9GZQ8 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Intra
MAP1LC3B Q9GZQ8 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
25416956
Intra
MAP1LC3B Q9GZQ8 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Intra
MAP1LC3B Q9GZQ8 KXD1 Homo sapiens Q9BQD3
Y2H Prey Pooling
25416956
Intra
MAP1LC3B Q9GZQ8 KXD1 Homo sapiens Q9BQD3
Y2H Array
25416956
Intra
MAP1LC3B Q9GZQ8 TBC1D5 Homo sapiens Q92609
BioID
34524948
Intra
MAP1LC3B Q9GZQ8 TBC1D5 Homo sapiens Q92609
Phage Display
35044719
Intra
MAP1LC3B Q9GZQ8 NBR1 Homo sapiens Q14596
Pull Down
19250911
Intra
MAP1LC3B Q9GZQ8 NBR1 Homo sapiens Q14596
Pull Down
24879152
Intra
MAP1LC3B Q9GZQ8 NBR1 Homo sapiens Q14596
Confocal
19250911
Intra
MAP1LC3B Q9GZQ8 UBA5 Homo sapiens Q9GZZ9
Pull Down
20562859
Intra
MAP1LC3B Q9GZQ8 BUB1 Homo sapiens O43683
FPS
39009827
Intra
MAP1LC3B Q9GZQ8 BUB1 Homo sapiens O43683
Anti Tag CoIP
39009827
Intra
MAP1LC3B Q9GZQ8 BRCA2 Homo sapiens P51587
FPS
39009827
Intra
MAP1LC3B Q9GZQ8 BRCA2 Homo sapiens P51587
ITC
39009827
Intra
MAP1LC3B Q9GZQ8 NCOA7 Homo sapiens Q8NI08
BioID
34524948
Intra
MAP1LC3B Q9GZQ8 ULK1 Homo sapiens O75385
Pull Down
24290141
Intra
MAP1LC3B Q9GZQ8 LMNB1 Homo sapiens P20700
BiFC
26524528
Intra
MAP1LC3B Q9GZQ8 LMNB1 Homo sapiens P20700
Anti Tag CoIP
26524528
Intra
MAP1LC3B Q9GZQ8 LMNB1 Homo sapiens P20700
Pull Down
26524528
Intra
MAP1LC3B Q9GZQ8 LMNB1 Homo sapiens P20700
Anti Bait CoIP
26524528
Intra
MAP1LC3B Q9GZQ8 ATG7 Homo sapiens O95352
Anti Tag CoIP
18083104
Intra
MAP1LC3B Q9GZQ8 ATG7 Homo sapiens O95352
Comig Non-Denat Gel
16303767
Intra
MAP1LC3B Q9GZQ8 ATG7 Homo sapiens O95352
Anti Tag CoIP
20562859
Intra
MAP1LC3B Q9GZQ8 ATG3 Homo sapiens Q9NT62
Anti Tag CoIP
18083104
Intra
MAP1LC3B Q9GZQ8 ATG3 Homo sapiens Q9NT62
Anti Tag CoIP
35271311
Intra
MAP1LC3B Q9GZQ8 ATG3 Homo sapiens Q9NT62
Anti Tag CoIP
20562859
Intra
MAP1LC3B Q9GZQ8 STK3 Homo sapiens Q13188
Anti Tag CoIP
20562859
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAP1LC3B Proteins

Cat. No. Product Name Accession Purity
HY-P70909 MAP1LC3B Protein, Human Q9GZQ8 (M1-V125) ≥ 95%, as determined by reducing SDS-PAGE.

MAP1LC3B Antibodies

Cat. No. Product Name Application Reactivity
HY-P80209 LC3B Antibody (YA308) WB, IHC-P, ICC/IF, IP, IF-Tissue, mIHC Human, Mouse, Rat
HY-P80741 LC3A/B Antibody WB Human, Mouse, Rat
HY-P80742 LC3B Antibody WB, ICC/IF, IHC-F, IHC-P Human, Mouse, Rat
HY-P86570 LC3B Antibody (YA6262) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Liver Carcinoma In Situ

  • Carcinoma In Situ Of Liver And Biliary System

  • Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Nervous System Disease

  • Abnormality Of The Nervous System

  • Nervous System Diseases

  • Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08029 MAP1LC3B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-186251 C18-Pyr-Cer Inducer / Unkown
HY-RS08030 MAP1LC3B2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18108 Map1lc3b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24582 Map1lc3b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MAP1LC3B RGD RGD:621315
Mus musculus MAP1LC3B MGD MGI:1914693